55646-99-6Relevant articles and documents
Preparation method of amcinonide
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Paragraph 0021-0026; 0034-0039; 0047-0052; 0060-0065; ..., (2021/11/27)
The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of amcinonide. The method comprises steps: taking a compound I as a raw material, firstly reacting with hydrofluoric acid and cyclopentanone, and then reacting under the action of acetic anhydride and potassium carbonate to obtain the amcinonide. Compared with the prior art, the compound I with lower price is used as a production raw material, so that the cost is reduced, the production amcinonide is easier, the yield is increased, and the amcinonide with better quality is obtained.