Journal of Medical Virology

Volume 75, Issue 2 p. 185-194

Research Article

An interferon-γ-related cytokine storm in SARS patients^†

Kao-Jean Huang,

Kao-Jean Huang

Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

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Ih-Jen Su,

Ih-Jen Su

Center for Disease Control, Department of Health, Taipei, Taiwan

Division of Clinical Research, National Health of Research Institute, Tainan, Taiwan

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Michel Theron,

Michel Theron

Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

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Yi-Chun Wu,

Yi-Chun Wu

Center for Disease Control, Department of Health, Taipei, Taiwan

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Shu-Kuan Lai,

Shu-Kuan Lai

Center for Disease Control, Department of Health, Taipei, Taiwan

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Ching-Chuan Liu,

Ching-Chuan Liu

Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

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Huan-Yao Lei,

Corresponding Author

Huan-Yao Lei

[email protected].

Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.===Search for more papers by this author

Kao-Jean Huang,

Kao-Jean Huang

Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

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Ih-Jen Su,

Ih-Jen Su

Center for Disease Control, Department of Health, Taipei, Taiwan

Division of Clinical Research, National Health of Research Institute, Tainan, Taiwan

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Michel Theron,

Michel Theron

Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

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Yi-Chun Wu,

Yi-Chun Wu

Center for Disease Control, Department of Health, Taipei, Taiwan

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Shu-Kuan Lai,

Shu-Kuan Lai

Center for Disease Control, Department of Health, Taipei, Taiwan

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Ching-Chuan Liu,

Ching-Chuan Liu

Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

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Huan-Yao Lei,

Corresponding Author

Huan-Yao Lei

[email protected].

Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.===Search for more papers by this author

First published: 15 December 2004

https://doi.org/10.1002/jmv.20255

Citations: 533

^†

Meeting presentation: International Conference of Influenza and the Resurgence of Severe Acute Respiratory Syndrome held on 28–31 October 2003, in Taipei, Taiwan. Abstract No. Session V-2.

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Abstract

Fourteen cytokines or chemokines were analyzed on 88 RT-PCR-confirmed severe acute respiratory syndrome (SARS) patients. IFN-γ, IL-18, TGF-β, IL-6, IP-10, MCP-1, MIG, and IL-8, but not of TNF-α, IL-2, IL-4, IL-10, IL-13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN-γ was significantly higher in the Ab(+) group than in the Ab(−) group. IFN-γ, IL-18, MCP-1, MIG, and IP-10 were already elevated at early days post fever onset. Furthermore, levels of IL-18, IP-10, MIG, and MCP-1 were significantly higher in the death group than in the survival group. For the survival group, IFN-γ and MCP-1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon-γ-related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients. J. Med. Virol. 75:185–194, 2005. © 2004 Wiley-Liss, Inc.

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Volume75, Issue2

February 2005

Pages 185-194

An interferon-γ-related cytokine storm in SARS patients^†

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An interferon-γ-related cytokine storm in SARS patients†

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An interferon-γ-related cytokine storm in SARS patients^†