Effects of Intermittent Fasting on Health, Aging, and Disease
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Published December 25, 2019
N Engl J Med 2019;381:2541-2551
DOI: 10.1056/NEJMra1905136
Abstract
Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity.
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This article was last updated on February 12, 2020, at NEJM.org.
Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.
We thank Drs. Michel Bernier and Anne E. Burke for valuable input, Mr. Marc Raley for work on previous versions of the figures, Dr. David G. Le Couteur for assistance with the preparation of an earlier version of the manuscript, and the Intramural Research Program of the National Institute on Aging, National Institutes of Health, for its support.
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Dan L. Longo, M.D., Editor
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Copyright © 2019 Massachusetts Medical Society. All rights reserved.
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Published online: December 25, 2019
Published in issue: December 26, 2019
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From the Translational Gerontology Branch (R.C.) and the Laboratory of Neurosciences (M.P.M.), Intramural Research Program, National Institute on Aging, National Institutes of Health, and the Department of Neuroscience, Johns Hopkins University School of Medicine (M.P.M.) — both in Baltimore.
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