Brief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite
Publication: Annals of Internal Medicine
Volume 141, Number 11
Abstract
Background:
Total sleep deprivation in rodents and in humans has been associated with hyperphagia. Over the past 40 years, self-reported sleep duration in the United States has decreased by almost 2 hours.
Objective:
To determine whether partial sleep curtailment, an increasingly prevalent behavior, alters appetite regulation.
Design:
Randomized, 2-period, 2-condition crossover clinical study.
Setting:
Clinical Research Center, University of Chicago, Chicago, Illinois.
Patients:
12 healthy men (mean age [±SD], 22 ± 2 years; mean body mass index [±SD], 23.6 ± 2.0 kg/m2).
Measurements:
Daytime profiles of plasma leptin and ghrelin levels and subjective ratings of hunger and appetite.
Intervention:
2 days of sleep restriction and 2 days of sleep extension under controlled conditions of caloric intake and physical activity.
Results:
Sleep restriction was associated with average reductions in the anorexigenic hormone leptin (decrease, 18%; P = 0.04), elevations in the orexigenic factor ghrelin (increase, 28%; P < 0.04), and increased hunger (increase, 24%; P < 0.01) and appetite (increase, 23%; P = 0.01), especially for calorie-dense foods with high carbohydrate content (increase, 33% to 45%; P = 0.02).
Limitations:
The study included only 12 young men and did not measure energy expenditure.
Conclusions:
Short sleep duration in young, healthy men is associated with decreased leptin levels, increased ghrelin levels, and increased hunger and appetite.
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Information & Authors
Information
Published In
Annals of Internal Medicine
Volume 141 • Number 11 • 7 December 2004
Pages: 846 - 850
History
Published online: 7 December 2004
Published in issue: 7 December 2004
Keywords
- Autonomic nervous system
- Body weight
- Diagnostic medicine
- Diet
- Digestive system
- Eating
- Endocrinology
- Food
- Gastroenterology and hepatology
- Hormones
- Ingestion
- Nervous system
- Neurology
- Nutrients
- Nutrition
- Peptide hormones
- Peripheral nervous system
- Prevention, policy, and public health
- Psychiatry and mental health
- Psychology
- Signs and symptoms
- Sleep
- Sleep disorders
- Social psychology
Copyright
© 2004 American College of Physicians.
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Brief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite. Ann Intern Med.2004;141:846-850. [Epub 7 December 2004]. doi:10.7326/0003-4819-141-11-200412070-00008
Brief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite. Ann Intern Med.2004;141:846-850. [Epub 7 December 2004]. doi:10.7326/0003-4819-141-11-200412070-00008
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