Abstract
The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells. Among other factors, compartment-specialized regulators of vesicular trafficking and other parts of membrane fusion machinery are likely to play a role in these processes. Here we summarize the emerging view of mycobacterial phagosome maturation arrest in the context of the dynamic processes of intracellular membrane trafficking.
Publication types
- Research Support, U.S. Gov't, P.H.S.
- Review
MeSH terms
- Carrier Proteins / physiology
- Cation Transport Proteins*
- Cells, Cultured
- Cytokines / physiology
- GTP-Binding Proteins / metabolism
- Membrane Proteins / physiology
- Microscopy, Confocal
- Models, Biological
- Mycobacterium bovis / metabolism
- Mycobacterium tuberculosis / physiology*
- Phagocytosis / physiology
- Phagosomes / metabolism*
- rab GTP-Binding Proteins*
- rab5 GTP-Binding Proteins
- rab7 GTP-Binding Proteins
Substances
- Carrier Proteins
- Cation Transport Proteins
- Cytokines
- Membrane Proteins
- natural resistance-associated macrophage protein 1
- rab7 GTP-Binding Proteins
- GTP-Binding Proteins
- rab GTP-Binding Proteins
- rab5 GTP-Binding Proteins