Enhanced Immunogenicity of Stabilized Trimeric Soluble Influenza Hemagglutinin
Figure 5
sHA.GCN4pII provides complete protection after two vaccinations unlike sHA.
Mice primed and boosted were challenged with 5 xLD50 of mouse adapted H3N2 A/Aichi/2/68. A, B. Body weights and survival were followed for 14 days post challenge. sHA (circle), sHA.GCN4 (square), PBS (inverted triangle). Open symbols with dashed line indicate % mean initial body weight of surviving mice for each group. Closed symbols with solid line indicate % mean initial body weight of mice showing signs of morbidity. (n = 6 per group)