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In this audio interview conducted on May 14, 2024, the editors are joined by Jeanne Marrazzo, director of the National Institute of Allergy and Infectious Diseases, and Arnold Monto, emeritus professor of public health at the University of Michigan.
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A study assessed the clinical, occupational, and financial effects associated with changing from race-based to race-neutral equations for the interpretation of lung function on millions of patients.
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This podcast episode considers a new treatment for hypertrophic cardiomyopathy, the world’s most common inherited heart condition, which most affected people don’t even realize they have.
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Including carbon footprint as an end point in randomized, controlled trials could help clinicians, regulators, and policymakers understand the environmental effects of medical interventions.
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Case finding for symptomatic adults with undiagnosed asthma or COPD was coupled with a randomized trial to compare pulmonologist-directed and usual care. Pulmonologist-directed care led to less health care utilization.
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In a trial involving patients with COPD and type 2 inflammation shown by elevated blood eosinophil counts, treatment with dupilumab reduced disease exacerbation and improved lung function.
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A modular leadless pacemaker in wireless communication with a subcutaneous ICD was shown to be safe and exceeded performance goals for communication between the pacemaker and ICD.
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In a trial involving 2404 patients with acute stroke and elevated blood pressure, ambulance-delivered systolic blood-pressure reduction did not result in better functional outcomes than usual care.
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This feature about an attending preparing for her upcoming week of service offers a case vignette accompanied by two essays, one supporting visiting patients early in the morning, before rounds, and the other recommending no prerounding.
Original Research
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In a phase 2b trial involving patients with hypertriglyceridemia, the use of olezarsen (which targets APOC3 mRNA) for 6 months reduced triglyceride levels by approximately 50% as compared with placebo.
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The factor Xa inhibitor reversal agent andexanet reduced expansion of intracerebral hemorrhages caused by factor Xa inhibitors but resulted in more thrombotic events than usual care.
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In a randomized trial of perioperative nivolumab as compared with chemotherapy, 18-month event-free survival was 70% in the nivolumab group and 50% in the chemotherapy group at 2-year median follow-up.
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The antibody that mediates the occurrence of VITT associated with adenoviral-based Covid-19 vaccines is nearly identical to the antibodies produced in response to natural adenoviral infection.
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This editorial describes the science behind an antisense drug targeting APOC3 mRNA to treat hypertriglyceridemia.
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The results of this phase 3 trial of the effect of olezarsen, a drug that targets APOC3 mRNA, on plasma triglyceride levels and acute pancreatitis in familial chylomicronemia syndrome support further clinical research.
Clinical Practice and Review
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A 73-year-old woman was transferred to the hospital because of rash, leukocytosis, and eosinophilia. CT revealed a mass in the lung and diffuse lymphadenopathy. What is the diagnosis?
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This second episode of the four-part Double Take video miniseries on depression delivers a primer on first- and second-line treatments for depression.
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A 66-year-old man with recently diagnosed cirrhosis associated with metabolic dysfunction–associated steatohepatitis presented with a 1-day history of melena and hematemesis.
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Increased global temperature is associated with a wide range of health risks, which are disproportionately high for certain populations. Individual- and population-level measures can reduce risks.
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Much of what we learned in school about how we taste is wrong. Progress in understanding how taste works is providing insights that may help in the management of obesity, diabetes, and other illnesses.
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A pediatrician caring for patients with a rare and life-limiting disease learns from his mentor the benefits of acknowledging that his story and his patients’ stories are inextricably intertwined.
Clinical Spotlight »
Exploring controversial topics in the recent literature.
Featured Article: New Terms to Describe the Steatotic Liver
