FEBS Letters

Volume 236, Issue 2 p. 462-466

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Synthetic magainin analogues with improved antimicrobial activity

Hao-Chia Chen,

Corresponding Author

Hao-Chia Chen

Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development Bethesda, MD 20892 USA

H.-C. Chen, Bldg. 6, Rm. 2A- 3, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892 USASearch for more papers by this author

Judith H. Brown,

Judith H. Brown

Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development Bethesda, MD 20892 USA

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John L. Morell,

John L. Morell

Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development Bethesda, MD 20892 USA

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C.M. Huang,

C.M. Huang

Clinical Pathology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 USA

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Hao-Chia Chen,

Corresponding Author

Hao-Chia Chen

Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development Bethesda, MD 20892 USA

Judith H. Brown,

Judith H. Brown

Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development Bethesda, MD 20892 USA

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John L. Morell,

John L. Morell

Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development Bethesda, MD 20892 USA

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C.M. Huang,

C.M. Huang

Clinical Pathology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 USA

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First published: August 29, 1988

https://doi.org/10.1016/0014-5793(88)80077-2

Citations: 225

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Abstract

Based on modifications to enhance the α-helical structure of the broad spectrum antibiotic magainin 2, a series of analogues have been synthesized which display an increase up to two orders of magnitude in antimicrobial activity and, in the most favorable case, no appreciable increase in hemolytic activity over magainin 1 at the concentrations tested.

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Volume236, Issue2

August 29, 1988

Pages 462-466

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