Biochemical and Biophysical Research Communications
Volume 279, Issue 2, 20 December 2000, Pages 324-329
Regular Article
Knockout of the Mouse Glutamate Cysteine Ligase Catalytic Subunit (Gclc) Gene: Embryonic Lethal When Homozygous, and Proposed Model for Moderate Glutathione Deficiency When Heterozygous
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2022, Journal of Nutritional BiochemistryCitation Excerpt :Interestingly, the embryonic lethality was observed in a gene knock-out mice research, which showed that GCLC is absolutely essential for fetal development [39]. Moreover, Zhai et al. (2013) revealed that dietary flavonoid can protect Caco-2 cells against oxidative stress by inducing GCLC protein expression [40]. As a protective agent, NQO1 catalyzes the two-electron reduction of quinoid compounds to the hydroquinone and thereby protecting the fetus against oxidative damage and improving the pregnancy outcomes [41].
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