Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach
Abstract
We propose a rational approach to the generation of live viral vaccines: alteration of virally encoded type I IFN antagonists to attenuate virulence while retaining immunogenicity. We have explored this concept by using the influenza virus. Previously we have shown that the NS1 protein of influenza A virus possesses anti-IFN activity. We now present evidence that influenza A and B viruses encoding altered viral NS1 proteins are highly attenuated in the mouse host, yet provide protection from challenge with wild-type viruses.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- April 2000
- DOI:
- 10.1073/pnas.070525997
- Bibcode:
- 2000PNAS...97.4309T
- Keywords:
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- Microbiology