Selective D2 Receptor Actions on the Functional Circuitry of Working Memory
Abstract
Prefrontal neurons engaged by working memory tasks express a sequence of phasic and tonic activations linked to a train of sensory, mnemonic, and response-related events. Here, we report that the dopamine D2 receptor selectively modulates the neural activities associated with memory-guided saccades in oculomotor delayed-response tasks yet has little or no effect on the persistent mnemonic-related activity, which is instead modulated by D1 receptors. This associates the D2 receptor with a specific component of working memory circuitry and fractionates the modulatory effects of D1 and D2 receptors on the neural machinery of a cognitive process.
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Experiments were conducted in accordance with the Yale University Animal Care and Use Committee and NIH guidelines. Supported by National Institute of Mental Health grants P50 MH44866 and P50 MH068789. We thank A. Arnsten, D. McCormick, and H. Friedman for reading this manuscript and for their critical comments and G. Leydon for help in developing Spike2 scripts.
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Published In
Science
Volume 303 | Issue 5659
6 February 2004
6 February 2004
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American Association for the Advancement of Science.
Submission history
Received: 4 September 2003
Accepted: 10 December 2003
Published in print: 6 February 2004
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