Abstract
We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections.
Publication types
- Research Support, Non-U.S. Gov't
MeSH terms
- Adult
- Aged
- Antibodies, Viral / blood*
- Antibody Formation / drug effects*
- Antibody Formation / immunology
- Antiviral Agents / therapeutic use
- Betacoronavirus / genetics
- Betacoronavirus / pathogenicity*
- COVID-19
- Coronavirus Infections / blood
- Coronavirus Infections / drug therapy*
- Coronavirus Infections / immunology
- Coronavirus Infections / virology
- Female
- Humans
- Immunoglobulin G / blood
- Immunoglobulin M / blood
- Male
- Middle Aged
- Pandemics / prevention & control
- Pneumonia, Viral / blood
- Pneumonia, Viral / drug therapy*
- Pneumonia, Viral / immunology
- Pneumonia, Viral / virology
- SARS-CoV-2
Substances
- Antibodies, Viral
- Antiviral Agents
- Immunoglobulin G
- Immunoglobulin M