Minocycline prevents the depressive-like behavior through inhibiting the release of HMGB1 from microglia and neurons.
Brain Behav Immun. 2020 Aug;88:132-143. doi: 10.1016/j.bbi.2020.06.019. Epub 2020 Jun 15. Brain Behav Immun. 2020. PMID: 32553784