Abstract
Multiple sclerosis (MS) patients were found to have elevated thiobarbituric acid reactive material levels, increased soluble sulfhydryl groups and reduced protein sulfhydryl groups in cerebrospinal fluid and serum, and slightly reduced superoxide dismutase in serum, which suggested disease activating free radical peroxidation. Moreover, levels of these varied across methylprednisolone (MP) therapy. We observed significant differences in the levels of peroxidation products between MS patients and controls. These changes were most evident in relapse. After MP therapy, levels of these indicators approached control values, especially in the remission period. Our findings suggest that MP protects against free radical attack.
MeSH terms
- Adult
- Female
- Free Radicals / blood*
- Free Radicals / cerebrospinal fluid*
- Glucocorticoids / therapeutic use*
- Humans
- Lipid Peroxidation / drug effects
- Lipid Peroxidation / physiology
- Male
- Methylprednisolone / therapeutic use
- Multiple Sclerosis / blood*
- Multiple Sclerosis / cerebrospinal fluid*
- Multiple Sclerosis / drug therapy
- Sulfhydryl Compounds / analysis
- Sulfhydryl Compounds / blood
- Sulfhydryl Compounds / cerebrospinal fluid
- Superoxide Dismutase / analysis
- Superoxide Dismutase / metabolism
- Superoxide Dismutase-1
- Thiobarbituric Acid Reactive Substances / analysis
- Thiobarbituric Acid Reactive Substances / metabolism
Substances
- Free Radicals
- Glucocorticoids
- SOD1 protein, human
- Sulfhydryl Compounds
- Thiobarbituric Acid Reactive Substances
- Superoxide Dismutase
- Superoxide Dismutase-1
- Methylprednisolone