ChemMedChem

Volume 15, Issue 4 p. 354-362

Communication

A Flexible Strategy for Modular Synthesis of Curcuminoid-BF₂/Curcuminoid Pairs and Their Comparative Antiproliferative Activity in Human Cancer Cell Lines

Prof. Rodrigo Abonia,

Prof. Rodrigo Abonia

[email protected]

Research Group of Heterocyclic Compounds, Department of Chemistry, Universidad del Valle A. A., 25360 Cali, Colombia

Department of Chemistry, University of North Florida, 1 UNF Drive, Jacksonville, Florida, 32224 USA

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Prof. Kenneth K. Laali,

Corresponding Author

Prof. Kenneth K. Laali

[email protected]

orcid.org/0000-0002-0294-844X

Department of Chemistry, University of North Florida, 1 UNF Drive, Jacksonville, Florida, 32224 USA

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Dawn Raja Somu,

Dawn Raja Somu

Department of Chemistry, University of North Florida, 1 UNF Drive, Jacksonville, Florida, 32224 USA

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Prof. Scott D. Bunge,

Prof. Scott D. Bunge

[email protected]

Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44242 USA

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Esther C. Wang,

Esther C. Wang

Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44242 USA

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Prof. Rodrigo Abonia,

Prof. Rodrigo Abonia

[email protected]

Research Group of Heterocyclic Compounds, Department of Chemistry, Universidad del Valle A. A., 25360 Cali, Colombia

Department of Chemistry, University of North Florida, 1 UNF Drive, Jacksonville, Florida, 32224 USA

Search for more papers by this author

Prof. Kenneth K. Laali,

Corresponding Author

Prof. Kenneth K. Laali

[email protected]

orcid.org/0000-0002-0294-844X

Department of Chemistry, University of North Florida, 1 UNF Drive, Jacksonville, Florida, 32224 USA

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Dawn Raja Somu,

Dawn Raja Somu

Department of Chemistry, University of North Florida, 1 UNF Drive, Jacksonville, Florida, 32224 USA

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Prof. Scott D. Bunge,

Prof. Scott D. Bunge

[email protected]

Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44242 USA

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Esther C. Wang,

Esther C. Wang

Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44242 USA

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First published: 24 December 2019

https://doi.org/10.1002/cmdc.201900640

Citations: 8

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Graphical Abstract

Curcumin's resurgence: We developed a flexible protocol that enables synthetic curcuminoid-BF₂/curcuminoid pairs to be interconverted. This widens their synthetic scope, allowing access to more diverse libraries of CUR-BF₂/CUR pairs for antiproliferative and apoptotic studies in cancer cell lines.

Abstract

A facile protocol that enables synthetic interconversion of CUR-BF₂ and CUR compounds is described that significantly widens the preparative scope of curcuminoids, providing access to larger libraries of compounds, thus enabling comparative antiproliferative and apoptotic study of a larger library of synthetic analogs in cancer cell lines.

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Volume15, Issue4

February 17, 2020

Pages 354-362

A Flexible Strategy for Modular Synthesis of Curcuminoid-BF₂/Curcuminoid Pairs and Their Comparative Antiproliferative Activity in Human Cancer Cell Lines

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Abstract

Supporting Information

References

Citing Literature

References

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A Flexible Strategy for Modular Synthesis of Curcuminoid-BF2/Curcuminoid Pairs and Their Comparative Antiproliferative Activity in Human Cancer Cell Lines

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A Flexible Strategy for Modular Synthesis of Curcuminoid-BF₂/Curcuminoid Pairs and Their Comparative Antiproliferative Activity in Human Cancer Cell Lines