Volume 30, Issue 11 p. 1504-1520
Review

Nonpharmacological treatments for patients with Parkinson's disease

Bastiaan R. Bloem MD, PhD

Corresponding Author

Bastiaan R. Bloem MD, PhD

Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands

These authors contributed equally to this manuscript.

Correspondence to: Prof. Bastiaan R. Bloem, Department of Neurology (935), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands, E-mail: [email protected]Search for more papers by this author
Nienke M. de Vries PhD

Nienke M. de Vries PhD

Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands

These authors contributed equally to this manuscript.

Search for more papers by this author
Georg Ebersbach MD, PhD

Georg Ebersbach MD, PhD

Movement Disorders Clinic, Beelitz-Heilstätten, Germany

Search for more papers by this author
First published: 14 August 2015
Citations: 191

Funding agencies: Prof. Bastiaan R. Bloem was supported by a centre grant of the National Parkinson Foundation.

Relevant conflicts of interest/financial disclosures: Nothing to report.

Full financial disclosures and author roles may be found in the online version of this article.

Abstract

Since 2013, a number of studies have enhanced the literature and have guided clinicians on viable treatment interventions outside of pharmacotherapy and surgery. Thirty-three randomized controlled trials and one large observational study on exercise and physiotherapy were published in this period. Four randomized controlled trials focused on dance interventions, eight on treatment of cognition and behavior, two on occupational therapy, and two on speech and language therapy (the latter two specifically addressed dysphagia). Three randomized controlled trials focused on multidisciplinary care models, one study on telemedicine, and four studies on alternative interventions, including music therapy and mindfulness. These studies attest to the marked interest in these therapeutic approaches and the increasing evidence base that places nonpharmacological treatments firmly within the integrated repertoire of treatment options in Parkinson's disease. © 2015 International Parkinson and Movement Disorder Society