Abstract
Curcuma longa L. (turmeric) belongs to the same family as ginger (Zingiberaceae) and is native to Southeast Asia (India and China); it is a fragrant perennial flowering erect herb, with rhizomes/tubers. The rhizomes are used as a spice (condiment)/food, dye-stuff, and for textile/beverage/cosmetic industries, in particular, curcumin its main constituent. The plant has been applied in the traditional medicine systems of Asia as treatments for respiratory/digestive/neurodegenerative disorders, as well as antiseptic/disinfectant, antidiabetic, antiinflammatory/antioxidant, antiplatelet/anticoagulant, antitumor/anticancer, antiviral, blood purifier, cardioprotective, hepatoprotective, wound-healing, etc. The main active principles of turmeric are curcuminoids and sesquiterpenoids (from essential oils), which would be responsible for the wide spectrum of bioproperties that the plant presents. Considering neurogenerative diseases, the most common are Alzheimer’s, Parkinson’s, Huntington’s, and Lou Gehrig’s (amyotrophic lateral sclerosis) diseases, on some of which turmeric and/or curcumin have proven the protective capabilities in certain in vitro/in vivo studies related to anti-inflammatory/antioxidant effects, oxidative stress reduction, etc. However, the most important limiting factor for the clinical application of curcumin is its poor pharmaco-kinetic/-dynamic properties. Therefore, the following question arises, could the curcuminoids and sesquiterpenoids of Curcuma longa rhizomes be the cure for neurodegenerative disorders? The answer is that these substances do not cure neurodegenerative disorders (there is no cure for them yet), but they would improve the quality of life of people who suffer from any of these diseases.
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The authors thank: Universidad Santo Tomás de Aquino (sede Bucaramanga) by using of the Bibliometric Unit; MinCiencias-SGR [Formación de Capital Humano (O.J.C.C., Convocatoria No. 1 Becas de Excelencia Bicentenario, 2019—Departamento de Sucre; C.P.G.G., Convocatoria No. 810, 2018—Departamento de La Guajira)].
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Muñoz-Acevedo, A., Guzmán, C.P., Castillo, O.J., Gutiérrez, R.G., Cervantes-Díaz, M. (2023). Curcuminoids and Sesquiterpenoids from Curcuma longa Rhizomes: Can They Be the Cure for Neurodegenerative Disorders?. In: Rai, M., Feitosa, C.M. (eds) Curcumin and Neurodegenerative Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-99-7731-4_7
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