Abstract
Objective
To compare the phase radians in several cerebral regions between patients with Parkinson’s disease (PD) and control subjects, and to evaluate whether iron deposition quantified by susceptibility-weighted imaging (SWI) is related to the severity of motor symptoms of PD.
Methods
SWI consisted of both magnitude and phase images from a fully flow-compensated, 3-dimensional and gradient-echo (GRE) sequence. Magnitude and phase data were collected at GE HD 1.5T. The regions evaluated included frontal white matter, grey matter, cerebrospinal fluid, putamen, caudate nucleus (CN), substantia nigra pars compacta (SNc), substantia nigra pars reticulata (SNr), and red nucleus (RN). A total number of 42 patients (12 patients without cognitive dysfunction, and 30 with cognitive dysfunction from mild to moderate degrees) and 30 control subjects were employed in the present study.
Results
The phase radians of SNc, CN and RN in PD patients were lower than those in control subjects (P<0.05).
Conclusion
The phase radians can be used to estimate the brain iron deposition in PD patients, which may be helpful in the diagnosis and longitudinal monitoring of PD.
摘要
目的
比较帕金森氏病(Parkinson’s disease, PD)患者和健康对照者多个脑结构的相位偏移值(phase radians), 探讨相位偏移值的临床应用价值。
方法
42 名PD患者及30 名年龄匹配的健康对照者均在1.5 T MR系统中进行头部检查。 所有PD 患者均存在轻度到中度认知功能缺损。 采用磁敏感成像获得相位图, 测量双侧尾状核、 壳核、 黑质致密带、 黑质网状带、 红核、 脑脊液、 额叶白质及额叶灰质内所感兴趣区的相位偏移值。
结果
与正常对照组相比, PD组黑质致密带的相位偏移值均数显著缩短(P < 0.05)。 此外, PD组双侧尾状核和红核的相位偏移值亦显著降低(P < 0.05), 而黑质网状带的相位偏移值与对照组相比无统计学差异(P > 0.05)。
结论
通过对相位偏移值的测定可以估测PD 患者脑内的铁沉积, 为PD 的活体诊断及病情监测提供帮助。
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Zhang, W., Sun, SG., Jiang, YH. et al. Determination of brain iron content in patients with Parkinson’s disease using magnetic susceptibility imaging. Neurosci. Bull. 25, 353–360 (2009). https://doi.org/10.1007/s12264-009-0225-8
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DOI: https://doi.org/10.1007/s12264-009-0225-8