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The influence of codon context on genetic code translation

Nature volume 286, pages 123–127 (1980)Cite this article

Abstract

A class of mutations that increase the efficiency of a suppressor tRNA in translating a particular amber codon has been characterized. The increased efficiency is due to a mutation resulting in a change in the mRNA that affects the nucleotide adjacent to the 3′ side of the UAG triplet. Thus the interaction of tRNA with mRNA is influenced by mRNA sequences outside the triplet codon.

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References

  1. Salser, W. Molec. gen. Genet. 105, 125–130 (1969).

    Article  CAS  Google Scholar 

  2. Fluck, M. M., Salser, W. & Epstein, R. H. Molec. gen. Genet. 151, 137–149 (1977).

    Article  CAS  Google Scholar 

  3. Yahata, H., Ocada, Y. & Tsugita, A. Molec. gen. Genet. 106, 208–212 (1970).

    Article  CAS  Google Scholar 

  4. Akaboshi, E., Inouye, M. & Tsugita, A. Molec. gen. Genet. 149, 1–4 (1976).

    Article  CAS  Google Scholar 

  5. Colby, D. S., Schedl, P. & Guthrie, C. Cell 9, 449–463 (1976).

    Article  CAS  Google Scholar 

  6. Feinstein, S. I. & Altman, S. J. molec. Biol. 112, 453–470 (1977).

    Article  CAS  Google Scholar 

  7. Feinstein, S. I. & Altman, S. Genetics 88, 201–219 (1979).

    Google Scholar 

  8. Taniguchi, T. & Weissmann, C. J. molec. Biol. 118, 533–565 (1978).

    Article  CAS  Google Scholar 

  9. Singer, C. E., Smith, G. R., Cortese, R. & Ames, B. N. Nature new Biol. 238, 72–74 (1972).

    Article  ADS  CAS  Google Scholar 

  10. Cortese, R., Kammen, H. O., Spengler, S. J. & Ames, B. N. J. biol. Chem. 249, 1103–1108 (1974).

    CAS  PubMed  Google Scholar 

  11. Ciampi, M. S., Arena, F., Cortese, R. & Daniel, V. FEBS Lett. 77, 75–82 (1977).

    Article  CAS  Google Scholar 

  12. Turnbough, C. L., Neill, R. J., Landsberg, R. & Ames, B. N. J. biol. Chem. 254, 5111–5119 (1979).

    CAS  PubMed  Google Scholar 

  13. Winston, F., Botstein, D. & Miller, J. H. J. Bact. 137, 433–439 (1979).

    CAS  PubMed  Google Scholar 

  14. Yaniv, M. & Folk, W. R. J. biol Chem. 250, 3243–3253 (1975).

    CAS  PubMed  Google Scholar 

  15. Hachiro, I., Fumiaki, Y., Hitoshi, S., & Ozeki, H. J. molec. Biol. 132, 649–662 (1979).

    Article  Google Scholar 

  16. Johnston, H. M., Barnes, W. M., Chumley, F. G., Bossi, L. & Roth, J. R. Proc. natn. Acad. Sci. U.S.A. 77, 508–512 (1980).

    Article  ADS  CAS  Google Scholar 

  17. Ino, I., Hartman, P. E., Hartman, Z. & Yourno, J. J. Bact. 123, 1254–1264 (1975).

    CAS  PubMed  Google Scholar 

  18. Creeb, J., Atkins, J. F. & Loper, J. C. J. Bact. 106, 421–431 (1971).

    Google Scholar 

  19. Newton, W. A., Beckwith, J. R., Zipser, D. & Brenner, S. J. molec. Biol. 14, 290–301 (1965).

    Article  CAS  Google Scholar 

  20. Roth, J. R., Anton, D. N. & Hartman, P. E. J. molec. Biol. 22, 305–323 (1966).

    Article  CAS  Google Scholar 

  21. Murray, M. L. & Hartman, P. E. Canad. J. Microbiol. 18, 671–681 (1972).

    Article  CAS  Google Scholar 

  22. Barnes, W. M. Gene 5, 127–139 (1979).

    Article  CAS  Google Scholar 

  23. Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

    Article  ADS  CAS  Google Scholar 

  24. Barnes, W. M. Proc. natn. Acad. Sci. U.S.A. 75, 4281–4285 (1978).

    Article  ADS  CAS  Google Scholar 

  25. Ciesla', Z., Salvatore, F., Broach, J. R., Artz, S. W. & Ames, B. N. Analyt. Biochem. 63, 44–55 (1975).

    Article  CAS  Google Scholar 

  26. Martin, R. G. et al. Meth. Enzym. 17, 3–44 (1971).

    Article  Google Scholar 

  27. Uhlenbeck, O. C., Baller, J. & Doty, P. Nature 225, 508–510 (1970).

    Article  ADS  CAS  Google Scholar 

  28. Grosjean, H., Söll, D. G. & Crothers, D. M. J. molec. Biol. 103, 499–519 (1976).

    Article  CAS  Google Scholar 

  29. Roth, J. R. A. Rev. Genetics 8, 319–346 (1974).

    Article  CAS  Google Scholar 

  30. Riddle, D. & Carbon, J. Nature new Biol. 242, 230–234 (1973).

    Article  CAS  Google Scholar 

  31. Kohno, T. & Roth, J. R. J. molec. Biol. 126, 37–52 (1978).

    Article  CAS  Google Scholar 

  32. Ames, B. N. & Hartman, P. E. Cold Spring Harb. Symp. quant. Biol. 28, 349–356 (1963).

    Article  CAS  Google Scholar 

  33. Stent, G. S. Science 144, 816–820 (1964).

    Article  ADS  CAS  Google Scholar 

  34. Chase, R., Tener, G. M. & Gillam, I. C. Arch. Biochem. Biophys. 163, 306–317 (1974).

    Article  CAS  Google Scholar 

  35. White, B. N., Tener, G. M., Holden, J. & Suzuki, D. T. Devl Biol. 33, 185–195 (1973).

    Article  CAS  Google Scholar 

  36. Delaney, P. & Siddiqui, M. A. Q. Devl Biol. 44, 54–62 (1976).

    Article  Google Scholar 

  37. Meza, L. et al. FEBS Lett. 77, 255–260 (1977).

    Article  CAS  Google Scholar 

  38. Kuchino, Y. & Borek, E. Nature 271, 126–129 (1978).

    Article  ADS  CAS  Google Scholar 

  39. Zilberstein, A., Dudock, B., Berissi, H. & Revel, M. J. molec. Biol. 108, 43–54 (1976).

    Article  CAS  Google Scholar 

  40. Guthrie, C. & McClain, W. H. Biochemistry 18, 3786–3795 (1979).

    Article  CAS  Google Scholar 

  41. Sprague, K. U., Hagenbüchle, O. & Zuniga, M. C. Cell 11, 561–570 (1977).

    Article  CAS  Google Scholar 

Download references

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Author notes

  1. Lionello Bossi

    Present address: European Molecular Biology Laboratory, Heidelberg, FRG

Authors and Affiliations

  1. Department of Biology, University of Utah, Salt Lake City, Utah, 84112

    Lionello Bossi & John R. Roth

  2. I Istituto di Chimica Biologica, Il Facolta' di Medicina e Chirurgia, University of Naples, Italy

    Lionello Bossi

Authors
  1. Lionello Bossi
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  2. John R. Roth
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Bossi, L., Roth, J. The influence of codon context on genetic code translation. Nature 286, 123–127 (1980). https://doi.org/10.1038/286123a0

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