Specificity in S-Nitrosylation: A Short-Range Mechanism for NO Signaling?
Publication: Antioxidants & Redox Signaling
Volume 19, Issue Number 11
Abstract
Significance: Nitric oxide (NO) classical and less classical signaling mechanisms (through interaction with soluble guanylate cyclase and cytochrome c oxidase, respectively) operate through direct binding of NO to protein metal centers, and rely on diffusibility of the NO molecule. S-Nitrosylation, a covalent post-translational modification of protein cysteines, has emerged as a paradigm of nonclassical NO signaling. Recent Advances: Several nonenzymatic mechanisms for S-nitrosylation formation and destruction have been described. Enzymatic mechanisms for transnitrosylation and denitrosylation have been also studied as regulators of the modification of specific subsets of proteins. The advancement of modification-specific proteomic methodologies has allowed progress in the study of diverse S-nitrosoproteomes, raising clues and questions about the parameters for determining the protein specificity of the modification. Critical Issues: We propose that S-nitrosylation is mainly a short-range mechanism of NO signaling, exerted in a relatively limited range of action around the NO sources, and tightly related to the very controlled regulation of subcellular localization of nitric oxide synthases. We review the nonenzymatic and enzymatic mechanisms that support this concept, as well as physiological examples of mammalian systems that illustrate well the precise compartmentalization of S-nitrosylation. Future Directions: Individual and proteomic studies of protein S-nitrosylation-based signaling should take into account the subcellular localization in order to gain further insight into the functional role of this modification in (patho)physiological settings. Antioxid. Redox Signal. 19, 1220–1235.
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Published In
Antioxidants & Redox Signaling
Volume 19 • Issue Number 11 • October 10, 2013
Pages: 1220 - 1235
PubMed: 23157283
Copyright
Copyright 2013, Mary Ann Liebert, Inc.
History
Published in print: October 10, 2013
Published online: 26 September 2013
Published ahead of print: 4 January 2013
Published ahead of production: 19 November 2012
Accepted: 18 November 2012
Received: 1 November 2012
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