CUTTING EDGE THERAPEUTICS: SCIENTIFIC REVIEWS
Salvemini, Daniela PhD; Cuzzocrea, Salvatore PhD
From Metaphore Pharmaceuticals, St Louis, MO (DS); and the Institute of Pharmacology, University of Messina, Messina, Italy (SO).
Treatment with superoxide dismutase mimetics, which selectively mimic the catalytic activity of the human superoxide dismutase enzymes, has been shown to prevent the cellular energetic failure associated with shock and ischemia-reperfusion and to prevent in vivo tissue damage associated with these conditions.