Volume 45, Issue 1 e13549

FULL ARTICLE

Safely effective hypoglycemic action of stevia and turmeric extracts on diabetic Albino rats

Abdalla El-Hadary,

Abdalla El-Hadary

orcid.org/0000-0002-5784-8606

Biochemistry Department, Faculty of Agriculture, Benha University, Benha, Egypt

Contribution: Conceptualization, Data curation, Investigation, Methodology, Resources, Visualization, Writing - original draft

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Mahmoud Sitohy,

Corresponding Author

Mahmoud Sitohy

[email protected]

orcid.org/0000-0001-6623-4860

Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt

Correspondence

Mahmoud Sitohy, Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.

Email: [email protected]

Contribution: Conceptualization, Investigation, Project administration, Supervision, Validation, Writing - original draft, Writing - review & editing

Search for more papers by this author

Abdalla El-Hadary,

Abdalla El-Hadary

orcid.org/0000-0002-5784-8606

Biochemistry Department, Faculty of Agriculture, Benha University, Benha, Egypt

Contribution: Conceptualization, Data curation, Investigation, Methodology, Resources, Visualization, Writing - original draft

Search for more papers by this author

Mahmoud Sitohy,

Corresponding Author

Mahmoud Sitohy

[email protected]

orcid.org/0000-0001-6623-4860

Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt

Correspondence

Mahmoud Sitohy, Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.

Email: [email protected]

Contribution: Conceptualization, Investigation, Project administration, Supervision, Validation, Writing - original draft, Writing - review & editing

Search for more papers by this author

First published: 08 November 2020

https://doi.org/10.1111/jfbc.13549

Citations: 6

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Abstract

The potentiality of Stevia leaves and turmeric roots as remedies against diabetes mellitus type 2 was tested in this study. Stevia leaves and turmeric roots were extracted with ethanol:water (80:20 v/v) and analyzed by HPLC. Turmeric extract (TUE) was rich in; curcumin, gallic acid, and eugenol. Stevia extract (STE) contained 28 known compounds, including glycosides, aromatic organic acids, and catechin. Fifty rats were divided into five groups (10 rats each); the control group were fed with feed and water ad libitum. Forty rats were injected a single dose of alloxan, then treated with either 10 mg/kg glibenclamide (GLI), 300 mg/kg STE, or 200 mg/kg TUE or water (positive control) through daily gastric oral gavages for 56 days. Treating diabetic rats with TUE significantly reduced serum glucose and glycated hemoglobin down to the negative control levels. Both GLI and STE produced similar but less effective actions. Animals treated with either STE or TUE exhibited reduced levels of liver and kidney markers compared to the negative control, while GLI increased them significantly. It could be concluded that turmeric roots and stevia leaves extracts can be used treatment for type 2 diabetes.

Practical applications

Turmeric roots and stevia leaves extracts may be used as a remedy for type 2 diabetic patients as aiding substituting treatments under medical supervision. The two plant sources can be used as raw materials for the extracts, which can be used under medical supervision as a gradual replacement of the synthetic antidiabetic drugs. These extracts can be used after a preliminary clinical study to determine the dose and frequency of administration. Stevia extract can be incorporated in drinks as a sweetener and drug. Turmeric extract has a bitter taste, so it may be incorporated in some foods such as bread, which is a traditional practice in some kinds of bread in Egypt. But its content in the bread and the acceptability of the taste should be adjusted. Alternatively, this food can incorporate both TUE and STE to get the best biological action and to conceal the bitter taste of turmeric.

CONFLICT OF INTEREST

The authors declare no conflict of interest.

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Volume45, Issue1

January 2021

e13549

Safely effective hypoglycemic action of stevia and turmeric extracts on diabetic Albino rats

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Practical applications

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Safely effective hypoglycemic action of stevia and turmeric extracts on diabetic Albino rats

Abstract

Practical applications

CONFLICT OF INTEREST

REFERENCES

Citing Literature

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