DNA Methylation Clocks and Their Predictive Capacity for Aging Phenotypes and Healthspan
Abstract
Introduction
Comparison of Different DNAm Clocks
DNAm clock | No. of CpGs (genes) | Age range | Sample size | Tissue | Platform | Reported associations | References |
---|---|---|---|---|---|---|---|
Chronological DNAm clocks | |||||||
DNAm-age | 3 (3) | 18-70 | 68 | Saliva | Illumina 27 K | Chronological age | Bocklandt et al9 |
Epigenetic-aging-signature | 19 (5) | 16-72 | 130 | Various cell types | Illumina 27 K | Chronological age | Koch and Wagner29 |
Florath age predictor | 17 (12) | 50-75 | 400 | Blood | Illumina 450K | Chronological age | Florath et al30 |
DNAm-age | 353 (344) | 0-101 | 8000 | Various cell & tissue types | Illumina 27K & 450K | Chronological age, all-cause mortality, cancer, age-related disease and several neurodegenerative phenotypes | Horvath11 |
DNAm-age | 71 (94) | 19-101 | 656 | Blood | Illumina 450K | Chronological age, all-cause mortality | Hannum et al12 |
DNAm-age | 3 (3) | 0-78 | 575 | Blood | Illumina 27K & 450K | Chronological age, clinical and lifestyle factors, telomere length and related diseases | Weidner et al13 |
Huang age prediction model | 5 (5) | 9-75 | 89 | Blood | Pyrosequencing | Chronological age for forensics | Huang et al31 |
Zbiec-Piekarska age predictor | 5 (5) | 2-75 | 420 | Blood | Pyrosequencing | Chronological age for forensics | Zbiec-Piekarska et al32 |
Zhang age predictor | 514 (396) | 2-104 | 13 566 | Blood & saliva | Illumina 450K & EPIC | Chronological age | Zhang et al33 |
Biological DNAm clocks | |||||||
epiTOC | 385 (175) | 19-101 | 656 | Blood | Illumina 450K | Mitotic age, cancer risk | Yang et al34 |
All-cause mortality clock | 10 (4) | 31–82 | 1000 | Blood | Illumina 450K | All-cause, cardiovascular disease and cancer mortality, cigarette smoking behaviour | Zhang et al35 |
MiAge | 286 (159) | NA | 4020 | 8 TTGA cancer cells | Illumina 450K | Mitotic age, cancer risk, survival | Youn and Wang36 |
DNAm PhenoAge | 513 (505) | >20 | 9926 | Blood | Illumina 27K, 450K & EPIC | All-cause and cause-specific mortality, survival, count of comorbidities, physical functioning, smoking status and telomere length | Levine et al14 |
DNAm GrimAge | 1030a (NA) | NA (mean 66) | 1731 | Blood | Illumina 450K & EPIC | Morbidity and mortality, survival, cognitive decline, clinical biomarkers, lifestyle factors, blood cell composition and telomere length | Lu et al37 |
DNAmTL | 140 (133) | 22-93 | 2256 | Blood | Illumina 450K & EPIC | Telomere length, chronological age, ethnicity, sex, lifestyle factors, mortality, morbidity, physical functioning | Lu et al38 |
Chronological DNAm clocks
Biological DNAm clocks
DNAm clocks in cell culture
Comparison of Genes in Different DNAm Clocks
Studies of DNAm Clocks in Neurodegenerative Diseases
Confounders of DNAm Clock Accuracy
Genetic confounders and stability of DNAm changes
Analysis platform and preprocessing methods
Confounders related to cohort age range
Tissue-related confounders
Discussion and Future Directions
Declaration of conflicting interests:
Funding:
ORCID iD
References
Supplementary Material
Please find the following supplemental material available below.
For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.
For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.
Cite article
Cite article
Cite article
Download to reference manager
If you have citation software installed, you can download article citation data to the citation manager of your choice
Information, rights and permissions
Information
Published In
Keywords
Authors
Author Contributions
Metrics and citations
Metrics
Article usage*
Total views and downloads: 6270
*Article usage tracking started in December 2016
Articles citing this one
Receive email alerts when this article is cited
Web of Science: 0
Crossref: 0
-
On the thermodynamics of DNA methylation process
-
Neighborhood Environment and Epigenetic Age: A Scoping Review
-
Pilot Study of Second-Generation DNA Methylation Epigenetic Markers in...
-
Whole‐genome methylation analysis of aging human tissues identifies ag...
-
Genetic and Epigenetic Study of Monozygotic Twins Affected by Parkinso...
-
How can we modulate aging through nutrition and physical exercise? An ...
-
Transdiagnostic evaluation of epigenetic age acceleration and burden o...
-
Accelerated epigenetic aging and myopenia in young adult cancer surviv...
-
Association of Race and Poverty Status With DNA Methylation–Based Age
-
Potential reversal of biological age in women following an 8-week meth...
-
DNA Methylation as a Biomarker for Monitoring Disease Outcome in Patie...
-
Within subject cross‐tissue analyzes of epigenetic clocks in substance...
-
Epigenetics
-
Risk Factors of Severe COVID-19: A Review of Host, Viral and Environme...
-
Associations Between Epigenetic Age Acceleration and microRNA Expressi...
-
Digital methylation assessments of alcohol and cigarette consumption a...
-
Dimensions of childhood adversity differentially affect biological agi...
-
Parkinson’s disease-associated, sex-specific changes in DNA methylatio...
-
Sex differences in epigenetic age in Mediterranean high longevity regi...
-
Life‐cycle control of 13‐ and 17‐year periodical cicadas: A hypothesis...
-
DNA repair as a shared hallmark in cancer and ageing
-
Epigenetic Clock Acceleration Is Linked to Age at Onset of Parkinson's...
-
Counteracting aged DNA methylation states to combat ageing and age-rel...
-
How alcohol makes the epigenetic clock tick faster and the clock rever...
-
Challenges and (Un)Certainties for DNAm Age Estimation in Future
-
Evaluation of different computational methods for DNA methylation-base...
-
Analysis of Epigenetic Age Acceleration and Healthy Longevity Among Ol...
-
A cautionary note on altered pace of aging in the COVID-19 era
-
Does diet influence aging? Evidence from animal studies
-
Telomere length and epigenetic clocks as markers of cellular aging: a ...
-
DNA methylation analysis of ELOVL2 gene using droplet digital PCR for ...
-
Inflammation, Aging, and Cardiovascular Disease
-
Pseudotime Analysis Reveals Exponential Trends in DNA Methylation Agin...
-
Loxl2 is a mediator of cardiac aging in Drosophila melan...
-
The Phenomenon of “Subjective Age” as an Epigenetic Cellular-Molecular...
-
Neurodegenerative movement disorders: An epigenetics perspective and p...
-
Progress and Prospects in Epigenetic Studies of Ancient DNA
-
An EPIC predictor of gestational age and its application to newborns c...
-
Characteristics of epigenetic aging across gestational and perinatal t...
-
Combined epigenetic/genetic study identified an ALS age of onset modif...
-
Достижения и перспективы эпигенетических исследований древней ДНК
-
Epigenetic Age Acceleration Is Not Associated with Age-Related Macular...
-
Impact of excessive alcohol abuse on age prediction using the VISAGE e...
-
Life course socioeconomic position and DNA methylation age acceleratio...
-
NEOage clocks - epigenetic clocks to estimate post-menstrual and postn...
-
DNA methylation‐based biomarkers of aging were slowed down in a two‐ye...
-
Epigenetic age prediction
-
Early-Onset Alzheimer’s Disease: What Is Missing in Research?
-
Implementing Precision Medicine in Human Frailty through Epigenetic Bi...
-
Systematic Review of Studies on Telomere Length in Patients with Multi...
-
Platform Communications: Abstract Book - 31st International Symposium ...
Figures and tables
Figures & Media
Tables
View Options
View options
PDF/ePub
View PDF/ePubGet access
Access options
If you have access to journal content via a personal subscription, university, library, employer or society, select from the options below:
loading institutional access options
Alternatively, view purchase options below:
Access journal content via a DeepDyve subscription or find out more about this option.