Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia
Abstract
The authors determined rates of brain atrophy, as assessed by the boundary shift integral on serial MRI, in patients with dementia with Lewy Bodies (DLB, n = 10), AD (n = 9), vascular dementia (VaD, n = 9), and age-matched controls (n = 20). Mean % ± SD atrophy rates per year were as follows: DLB, 1.4 ± 1.1; AD, 2.0 ± 0.9; VaD, 1.9 ± 1.1; and controls, 0.5 ± 0.7. Dementia subjects had higher rates than controls (p < 0.001), but there were no significant differences between the three dementia groups. The authors found accelerating atrophy with increasing severity of cognitive impairment, further emphasizing the need for early diagnosis and intervention in dementia.
Get full access to this article
View all available purchase options and get full access to this article.
Supplementary Material
File (obrie522.doc)
- Download
- 28.00 KB
References
1.
Perry RH, Irving D, Blessed G, et al. Senile dementia of Lewy body type: a clinically and neuropathologically distinct form of Lewy body dementia in the elderly. J Neurol Sci . 1990; 95: 119–139.
2.
McKeith I, Ballard C, O’Brien J, et al. Predictive accuracy of clinical diagnostic criteria for dementia with Lewy bodies: a prospective neuropathological validation study. Neurology . 2000; 54: 1050–1058.
3.
McKeith IG, O’Brien JT, Ballard C. Diagnosing dementia with Lewy bodies. Lancet . 1999; 354: 1227–1228.
4.
Barber R, Gholkar A, Ballard C, et al. MRI volumetric study of dementia with Lewy bodies, Alzheimer’s disease and vascular dementia. Neurology . 2000; 54: 1304–1309.
5.
Fox NC, Freeborough PA. Brain atrophy progression measured from registered serial MRI: validation and application to Alzheimer’s disease. J Magn Reson Imaging . 1997; 7: 1069–1075.
6.
Fox NC, Freeborough PA, Rossor MN. Visualisation and quantification of rates of atrophy in Alzheimer’s disease. Lancet . 1996; 348: 94–97.
7.
Freeborough PA, Fox NC. The boundary shift integral: an accurate and robust measure of cerebral volume changes from registered repeat MRI. IEEE Trans Med Imaging . 1997; 16: 623–629.
8.
Fox NC, Cousens S, Scahill R, Harvey RJ, et al. Using serial registered brain magnetic resonance imaging to measure disease progression in Alzheimer disease: power calculations and estimates of sample size to detect treatment effects. Arch Neurol . 2000; 57: 339–344.
9.
Morris JC, Edland S, Clark C, et al. The consortium to establish a registry for Alzheimer’s disease (CERAD). Part IV. Rates of cognitive change in the longitudinal assessment of probable Alzheimer’s disease. Neurology . 1993; 43: 2457–2465.
10.
Teri L, McCurry SM, Edland SD, et al. Cognitive decline in Alzheimer’s disease: a longitudinal investigation of risk factors for accelerated decline. J Gerontol A Biol Sci Med Sci . 1995; 50A: M49–M55.
Information & Authors
Information
Published In
Copyright
© 2001.
Publication History
Received: September 25, 2000
Accepted: January 26, 2001
Published online: May 22, 2001
Published in print: May 22, 2001
Authors
Metrics & Citations
Metrics
Citations
Download Citations
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from the list below and click Download.
Cited By
- Neuroimaging in Dementia, CONTINUUM: Lifelong Learning in Neurology, 29, 1, (219-254), (2023).https://doi.org/10.1212/CON.0000000000001248
- The use of neuroimaging techniques in the early and differential diagnosis of dementia, Molecular Psychiatry, (2023).https://doi.org/10.1038/s41380-023-02215-8
- Dementia with Lewy bodies, Dialogues in Clinical Neuroscience, 6, 3, (333-341), (2022).https://doi.org/10.31887/DCNS.2004.6.3/imckeith
- Functional Imaging for Neurodegenerative Diseases, La Presse Médicale, 51, 2, (104121), (2022).https://doi.org/10.1016/j.lpm.2022.104121
- A Comparative Analysis of MRI Automated Segmentation of Subcortical Brain Volumes in a Large Dataset of Elderly Subjects, Neuroinformatics, 20, 1, (63-72), (2021).https://doi.org/10.1007/s12021-021-09520-z
- Malattia a corpi di Lewy, EMC - Neurologia, 20, 3, (1-7), (2020).https://doi.org/10.1016/S1634-7072(20)44006-1
- Predicting the Aqueductal Cerebrospinal Fluid Pulse: A Statistical Approach, Applied Sciences, 9, 10, (2131), (2019).https://doi.org/10.3390/app9102131
- Cerebrospinal Fluid, Imaging, and Physiological Biomarkers in Dementia With Lewy Bodies, American Journal of Alzheimer's Disease & Other Dementias®, 34, 7-8, (421-432), (2019).https://doi.org/10.1177/1533317519869700
- Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis, Dementia and Geriatric Cognitive Disorders Extra, 8, 1, (51-59), (2018).https://doi.org/10.1159/000486849
- Global Cerebral Atrophy Detected by Routine Imaging: Relationship with Age, Hippocampal Atrophy, and White Matter Hyperintensities, Journal of Neuroimaging, 28, 3, (301-306), (2018).https://doi.org/10.1111/jon.12494
- See more
Loading...
View Options
Get Access
Login options
Check if you have access through your login credentials or your institution to get full access on this article.
Personal login Institutional LoginPurchase Options
Purchase this article to get full access to it.