Abstract
SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers-individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease-present a unique opportunity to reveal human genetic determinants of infection and disease.
Copyright © 2020 Elsevier Inc. All rights reserved.
Publication types
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
MeSH terms
- Age Factors
- Betacoronavirus / physiology
- COVID-19
- Coronavirus Infections / epidemiology
- Coronavirus Infections / genetics*
- Coronavirus Infections / immunology*
- Coronavirus Infections / physiopathology
- Disease Resistance
- Genetic Association Studies
- Genetic Diseases, Inborn / immunology
- Genetic Predisposition to Disease*
- Genetic Variation
- Genome, Human
- Host-Pathogen Interactions
- Humans
- Infections / genetics
- Infections / immunology
- Infections / physiopathology
- Pandemics
- Pneumonia, Viral / epidemiology
- Pneumonia, Viral / genetics*
- Pneumonia, Viral / immunology*
- Pneumonia, Viral / physiopathology
- SARS-CoV-2