Chemistry Europe

Now open for submissions! Our new open access journal, ChemistryEurope, serves the chemistry community by bringing together the brightest minds and by providing a platform for original and inspirational work from across the discipline. Submit here: https://lnkd.in/eweECxfS

#Metallodrugs are effective weapons in the fight against #cancer. One of the oldest entries into this substance class, #cisplatin, continues to be used to this day. Beyond platinum-containing compounds, which were extensively investigated for their antiproliferative properties, many other metals are also explored for their use in cancer therapy. It is, however, not only the metal but also the organic #ligands that determine the effectiveness and specificity of metallodrugs. María Gil-Moles (CISQ, Universidad de La Rioja) and Concepción Gimeno (ISQCH, Universidad de Zaragoza) highlight and summarize the research on #terpyridine complexes of the coinage metals, copper, silver, and gold. Terpyridines are biologically active themselves, for example as DNA intercalators, and their metal complexes show promising pharmacochemistry. The team reviews structures and mechanisms and identifies open questions for the field. Our Pick of the Week, published #OpenAccess in #ChemMedChem: "The Therapeutic Potential in Cancer of Terpyridine-Based Metal Complexes Featuring Group 11 Elements" https://ow.ly/tb7G50RmTSL

Enzyme engineering is a great way to take the power of enzymes one step further. By so-called “directed evolution”, researchers mimic how evolution works in nature, for example mutating chosen amino acid constituents of proteins that are important for their function. Making smart choices such as limiting possible replacements to such that would also occur in nature can help reducing the vast chemical space that might need to be sampled in such investigations. Kai Schülke, Jana Fröse, Alina Klein, Marc Garcia Borràs (Universitat Girona) and Stephan Hammer (Universität Bielefeld) have used this approach to efficiently engineer transferases that can be used to very efficiently alkylate S-adenosyl-L-homocysteine with high enantioselectivity using commercially available iodoalkane reagents. The team used UHPLC-ESI-MS-based high-throughput screening to quickly identify suitable mutants based on the alteration of “hotspot” amino acid positions identified by molecular dynamics simulations. Their approach allowed hit identification in very short times and could also be used to engineer related systems. Our Pick of the Week, published #OpenAccess in #ChemBioChem: "Efficient Transferase Engineering for SAM Analog Synthesis from Iodoalkanes" https://ow.ly/Cku050Rinsp

The new issue of ChemMedChem is out (https://lnkd.in/dkQcmJY2), with a front cover illustrating the hydrolysis of the endogenous substrate glucosylceramide into glycosyl and ceramide by the enzyme glucocerebrosidase (GCase). Activators from two distinct chemotypes are bound to two distinct sites on GCase: one (in green) is located close to the substrate binding site while the other (in purple) is further away from the catalytic pocket. More information can be found in the Research Article by Monika-Sarah (Sarah) Schulze, PhD, Diana Scholz, Eric Jnoff, adrian hall, Jonathan Melin, Zara Sands, Elizabeth Rodriguez, Veronique Andre (https://lnkd.in/dUe2aCht). Chemistry Europe EFMC - European Federation for Medicinal Chemistry and Chemical Biology EFMC Young Scientists Network Divisione di Chimica Farmaceutica DCF-SCI

🔮 What will the Sustainable Future smell like? The transition from today’s resource-wasting petrochemical economy towards a 100/100 renewable and biodegradable future is inevitable and has in fact already begun. For some fragrance families, highly performant sustainable alternatives are easier to find than for others, and for some they already existed since their very introduction. The historic routes to synthetic vanillin, which currently celebrates its 150th anniversary, for instance all commenced from renewable starting materials: first coniferin, then guaiacol ex beechwood tar, and finally eugenol, abundantly occurring in clove oil. We have summarized the challenges and opportunities that rise from the ashes of fossil fuels in a review that just appeared in ‘Chemistry – A European Journal’: “Sniffing Out the Sustainable Future: The Renewability Revolution in Fragrance Chemistry” (Chem. Eur. J. 2024, e202400006), available as 🔓 OpenAccess download from https://bit.ly/3Tz75s2 (https://lnkd.in/eh-bJ3bh). Feel invited to learn about the impact the 100/100 transition has on the different fragrance families, where we are in need of renewable fragrance ingredients, and how you can participate in the discovery of these. Perfumery is reinventing itself, and as in the past, Fragrance Chemistry will be its propulsive power. 📰 Enjoy the read! #TheFutureisNow #Sustainability #Renewability #Biodegradability #EasterWeekend #Perfumery #Fragrances #GreenChemistry #GoGreen #ClimateChange #ZeroWaste #GreenLiving #EcoFashion #SavethePlanet  #BackwardIntegration #Symrise #AlwaysInspiringMore

Thank you Chemistry Europe for becoming a media partner 🙌 🔋 💡 During the Battery 2030+ annual conference May 28-29th in Grenoble, three poster prizes will be sponsored by Chemistry Europe Chemistry Europe is an association of 16 chemical societies from 15 European countries. It publishes a family of high-quality scholarly chemistry journals, covering a very broad range of disciplines. Submit your abstract, focusing on next-generation battery technologies, such as future battery chemistries, smart functionalities, accelerated material discovery, advanced battery modelling and characterization, new manufacturing and recycling processes. Find more information here, https://lnkd.in/dzusmaxg Abstract submission deadline: April 21st, 2024

The Editor-in-Chief of ChemPlusChem Axel Straube spoke to ChemistryViews after his appointment. Have a look! https://lnkd.in/dkWfM3bt

Join the upcoming 2023 EurJOC-Society Award Virtual Symposium! The selected laureates will present their excellent research published in the European Journal of Organic Chemistry: 🗓️April 10, 2024 ⏲️2 - 5 pm CEST (UTC+2) Registration is still open: https://lnkd.in/evUhMUBB

🔬 Nur noch wenige Plätze verfügbar für das Alpenforum 2024! 🏔️ Sichert euch jetzt die Chance, inmitten des atemberaubenden Alpenpanoramas zu netzwerken und spannende Karrierewege in der Chemie zu erkunden. Markiert euch den 03.-05. Mai 2024 und sichert euch euren Platz! Anmeldung: https://lnkd.in/d5B9bQqr

🌟 Erfahre mehr über unsere Top-Referenten beim Alpenforum 2024! 🌟 👨🔬 Willis .C. Muganda - Expert Scouting Renewable Raw Materials bei BASF 👩🔬 Dr. Janina Meyer R&D - Managerin Biobased Processes bei Evonik 👨🔬 Dr. Christian Schneider - Project Leader consulting bei Boston Consulting Group (BCG) 👨🔬 Alexander Hammer - CEO und Co-Founder von Dunia 👨🔬 Dr. David Mayer - Stellvertretende Referatsleiter beim Bayrisches Landesamt für Umwelt 🗓️ Markiere dir den 03.-05. Mai 2024 und sei dabei, um von diesen inspirierenden Referenten zu lernen! 💡 Sichere dir jetzt deinen Platz: https://lnkd.in/d5B9bQqr #Alpenforum2024 #Karrierewege #Chemie #JobChemie #Chemieindustrie #Networking #Netzwerken #BASF #Evonik #BCG #JCF #GDCh