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Understanding the Placebo Effect: Contributions from Neuroimaging

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An Erratum to this article was published on 17 March 2007

Abstract

Neuroimaging studies have provided a major contribution to our understanding of the mechanisms of the placebo effect in neurological and psychiatric disorders. Expectation of symptom improvement has long been believed to play a critical role in the placebo effect, and is associated with increased endogenous striatal dopamine release in Parkinson’s disease and increased endogenous opioid transmission in placebo analgesia. Evidence from positron emission tomography and functional magnetic resonance imaging studies suggests that expectations of symptom improvement are driven by frontal cortical areas, particularly the dorsolateral prefrontal, orbitofrontal, and anterior cingulate cortices. The ventral striatum is involved in the expectation of rewarding stimuli and, together with the prefrontal cortex, has also been shown to play an important role in the placebo-induced expectation of therapeutic benefit. Understanding the mechanisms of the placebo effect has important implications for treatment of several medical conditions, including depression, pain, and Parkinson’s disease.

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References

  1. Lindvall O, Bjorklund A (1978) Anatomy of the dopaminergic neuron systems in the rat brain. Adv Biochem Psychopharmacol 19:1–23

    PubMed  CAS  Google Scholar 

  2. Haber SN, Fudge JL (1997) The primate substantia nigra and VTA: integrative circuitry and function. Crit Rev Neurobiol 11(4):323–342

    PubMed  CAS  Google Scholar 

  3. Joel D, Weiner I (2000) The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum. Neuroscience 96(3):451–474

    PubMed  CAS  Google Scholar 

  4. Haber SN (2003) The primate basal ganglia: parallel and integrative networks. J Chem Neuroanat 26(4):317–330

    PubMed  Google Scholar 

  5. Alexander GE, DeLong MR, Strick PL (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9:357–381

    PubMed  CAS  Google Scholar 

  6. Stewart-Williams S, Podd J (2004) The placebo effect: dissolving the expectancy versus conditioning debate. Psychol Bull 130(2):324–340

    PubMed  Google Scholar 

  7. de Craen AJ, Tijssen JG, de Gans J, Kleijnen J (2000) Placebo effect in the acute treatment of migraine: subcutaneous placebos are better than oral placebos. J Neurol 247(3):183–188

    PubMed  Google Scholar 

  8. Brody H (1980) Placebos and the philosophy of medicine: clinical, conceptual, and ethical issues. Chicago: The University of Chicago Press

    Google Scholar 

  9. Kaptchuk TJ, Goldman P, Stone DA, Stason WB (2000) Do medical devices have enhanced placebo effects? J Clin Epidemiol 53(8):786–792

    PubMed  CAS  Google Scholar 

  10. Shapiro AK, Shapiro E (1997) The placebo: is it much ado about nothing? In: Harrington A (ed) The placebo effect: an interdisciplinary exploration. Cambridge: Harvard University Press, pp 12–36

    Google Scholar 

  11. Moseley JB, O’Malley K, Petersen NJ, et al. (2002) A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 347(2):81–88

    PubMed  Google Scholar 

  12. de la Fuente-Fernandez R, Stoessl AJ (2002) The biochemical bases for reward. Implications for the placebo effect. Eval Health Prof 25(4):387–398

    Google Scholar 

  13. Diamond SG, Markham CH, Treciokas LJ (1985) Double-blind trial of pergolide for Parkinson’s disease. Neurology 35(3):291–295

    PubMed  CAS  Google Scholar 

  14. Goetz CG, Leurgans S, Raman R (2002) Placebo-associated improvements in motor function: comparison of subjective and objective sections of the UPDRS in early Parkinson’s disease. Mov Disord 17(2):283–288

    PubMed  Google Scholar 

  15. Goetz CG, Leurgans S, Raman R, Stebbins GT (2000) Objective changes in motor function during placebo treatment in PD. Neurology 54(3):710–714

    PubMed  CAS  Google Scholar 

  16. Shetty N, Friedman JH, Kieburtz K, Marshall FJ, Oakes D (1999) The placebo response in Parkinson’s disease. Parkinson Study Group. Clin Neuropharmacol 22(4):207–212

    PubMed  CAS  Google Scholar 

  17. Freeman TB, Vawter DE, Leaverton PE, et al. (1999) Use of placebo surgery in controlled trials of a cellular-based therapy for Parkinson’s disease. N Engl J Med 341(13):988–992

    PubMed  CAS  Google Scholar 

  18. Macklin R (1999) The ethical problems with sham surgery in clinical research. N Engl J Med 341(13):992–996

    PubMed  CAS  Google Scholar 

  19. Weijer C (2002) I need a placebo like I need a hole in the head. J Law Med Ethics 30(1):69–72

    PubMed  Google Scholar 

  20. London AJ, Kadane JB (2002) Placebos that harm: sham surgery controls in clinical trials. Stat Methods Med Res 11(5):413–427

    PubMed  Google Scholar 

  21. Watts RL, Freeman TB, Hauser RA, et al. (2001) A double-blind, randomised, controlled, multicenter clinical trial of the safety and efficacy of stereotaxic intrastriatal implantation of fetal porcine ventral mesencephalic tissue (Neurocell™-PD) vs. imitation surgery in patients with Parkinson’s disease (PD). Parkinsonism Relat Disord 7:S87

    Google Scholar 

  22. Olanow CW, Goetz CG, Kordower JH, et al. (2003) A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson’s disease. Ann Neurol 54(3):403–414

    PubMed  Google Scholar 

  23. Hauser RA, Freeman TB, Snow BJ, et al. (1999) Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease. Arch Neurol 56(2):179–187

    PubMed  CAS  Google Scholar 

  24. Freed CR, Greene PE, Breeze RE, et al. (2001) Transplantation of embryonic dopamine neurons for severe Parkinson’s disease. N Engl J Med 344(10):710–719

    PubMed  CAS  Google Scholar 

  25. McRae C, Cherin E, Yamazaki TG, et al. (2004) Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial. Arch Gen Psychiatry 61(4):412–420

    PubMed  Google Scholar 

  26. Fuente-Fernandez R, Schulzer M, Stoessl AJ (2002) The placebo effect in neurological disorders. Lancet Neurol 1(2):85–91

    PubMed  Google Scholar 

  27. Mercado R, Constantoyannis C, Mandat T, et al. (2006) Expectation and the placebo effect in Parkinson’s disease patients with subthalamic nucleus deep brain stimulation. Mov Disord 21(9):1457–1461

    PubMed  Google Scholar 

  28. Pollo A, Torre E, Lopiano L, et al. (2002) Expectation modulates the response to subthalamic nucleus stimulation in Parkinsonian patients. Neuroreport 13(11):1383–1386

    PubMed  Google Scholar 

  29. Benedetti F, Pollo A, Lopiano L, et al. (2003) Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses. J Neurosci 23(10):4315–4323

    PubMed  CAS  Google Scholar 

  30. Benedetti F, Colloca L, Lanotte M, et al. (2004) Autonomic and emotional responses to open and hidden stimulations of the human subthalamic region. Brain Res Bull 63(3):203–211

    PubMed  Google Scholar 

  31. Benedetti F, Colloca L, Torre E, et al. (2004) Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus. Nat Neurosci 7(6):587–588

    PubMed  CAS  Google Scholar 

  32. Dewey SL, Smith GS, Logan J, et al. (1993) Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects. Proc Natl Acad Sci U S A 90(24):11816–11820

    PubMed  CAS  Google Scholar 

  33. Endres CJ, Kolachana BS, Saunders RC, et al. (1997) Kinetic modeling of [11C]raclopride: combined PET-microdialysis studies. J Cereb Blood Flow Metab 17(9):932–942

    PubMed  CAS  Google Scholar 

  34. Breier A, Su TP, Saunders R, et al. (1997) Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method. Proc Natl Acad Sci U S A 94(6):2569–2574

    PubMed  CAS  Google Scholar 

  35. Volkow ND, Wang GJ, Fowler JS, et al. (1999) Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D2 receptors. J Pharmacol Exp Ther 291(1):409–415

    PubMed  CAS  Google Scholar 

  36. Drevets WC, Gautier C, Price JC, et al. (2001) Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria. Biol Psychiatry 49(2):81–96

    PubMed  CAS  Google Scholar 

  37. Volkow ND, Wang G, Fowler JS, et al. (2001) Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain. J Neurosci 21(2):RC121

    PubMed  CAS  Google Scholar 

  38. Leyton M, Boileau I, Benkelfat C, et al. (2002) Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C]raclopride study in healthy men. Neuropsychopharmacology 27(6):1027–1035

    PubMed  CAS  Google Scholar 

  39. Martinez D, Slifstein M, Broft A, et al. (2003) Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum. J Cereb Blood Flow Metab 23(3):285–300

    PubMed  CAS  Google Scholar 

  40. Oswald LM, Wong DF, McCaul M, et al. (2005) Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamine. Neuropsychopharmacology 30(4):821–832

    PubMed  CAS  Google Scholar 

  41. Schlaepfer TE, Pearlson GD, Wong DF, Marenco S, Dannals RF (1997) PET study of competition between intravenous cocaine and [11C]raclopride at dopamine receptors in human subjects. Am J Psychiatry 154(9):1209–1213

    PubMed  CAS  Google Scholar 

  42. Brody AL, Olmstead RE, London ED, et al. (2004) Smoking-induced ventral striatum dopamine release. Am J Psychiatry 161(7):1211–1218

    PubMed  Google Scholar 

  43. Barrett SP, Boileau I, Okker J, Pihl RO, Dagher A (2004) The hedonic response to cigarette smoking is proportional to dopamine release in the human striatum as measured by positron emission tomography and [11C]raclopride. Synapse 54(2):65–71

    PubMed  CAS  Google Scholar 

  44. Volkow ND, Wang GJ, Telang F, et al. (2006) Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction. J Neurosci 26(24):6583–6588

    PubMed  CAS  Google Scholar 

  45. Adler CM, Elman I, Weisenfeld N, et al. (2000) Effects of acute metabolic stress on striatal dopamine release in healthy volunteers. Neuropsychopharmacology 22(5):545–550

    PubMed  CAS  Google Scholar 

  46. Zald DH, Boileau I, El Dearedy W, et al. (2004) Dopamine transmission in the human striatum during monetary reward tasks. J Neurosci 24(17):4105–4112

    PubMed  CAS  Google Scholar 

  47. Koepp MJ, Gunn RN, Lawrence AD, et al. (1998) Evidence for striatal dopamine release during a video game. Nature 393(6682):266–268

    PubMed  CAS  Google Scholar 

  48. Piccini P, Pavese N, Brooks DJ (2003) Endogenous dopamine release after pharmacological challenges in Parkinson’s disease. Ann Neurol 53(5):647–653

    PubMed  CAS  Google Scholar 

  49. de la Fuente-Fernandez R, Ruth TJ, Sossi V, et al. (2001) Expectation and dopamine release: mechanism of the placebo effect in parkinson’s disease. Science 293(5532):1164–1166

    PubMed  Google Scholar 

  50. Strafella AP, Ko JH, Monchi O (2006) Therapeutic application of transcranial magnetic stimulation in Parkinson’s disease: the contribution of expectation. Neuroimage 31(4):1666–1672

    PubMed  Google Scholar 

  51. Kirsch I (1997) Specifying nonspecifics: psychological mechanisms of placebo effects. In: Harrington A (ed) The placebo effect: an interdisciplinary exploration. Cambridge: Harvard University Press, pp 166–186

    Google Scholar 

  52. de la Fuente-Fernandez R, Phillips AG, Zamburlini M, et al. (2002) Dopamine release in human ventral striatum and expectation of reward. Behav Brain Res 136(2):359–363

    PubMed  Google Scholar 

  53. Berridge KC, Robinson TE (1998) What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Rev 28(3):309–369

    PubMed  CAS  Google Scholar 

  54. Ikemoto S, Panksepp J (1999) The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking. Brain Res Rev 31(1):6–41

    PubMed  CAS  Google Scholar 

  55. Mogenson GJ, Jones DL, Yim CY (1980) From motivation to action: functional interface between the limbic system and the motor system. Prog Neurobiol 14(2–3):69–97

    PubMed  CAS  Google Scholar 

  56. Apicella P, Scarnati E, Ljungberg T, Schultz W (1992) Neuronal activity in monkey striatum related to the expectation of predictable environmental events. J Neurophysiol 68(3):945–960

    PubMed  CAS  Google Scholar 

  57. Fiorillo CD, Tobler PN, Schultz W (2003) Discrete coding of reward probability and uncertainty by dopamine neurons. Science 299(5614):1898–1902

    PubMed  CAS  Google Scholar 

  58. Schultz W, Dayan P, Montague PR (1997) A neural substrate of prediction and reward. Science 275(5306):1593–1599

    PubMed  CAS  Google Scholar 

  59. Schultz W (1998) Predictive reward signal of dopamine neurons. J Neurophysiol 80(1):1–27

    PubMed  CAS  Google Scholar 

  60. Schultz W, Apicella P, Scarnati E, Ljungberg T (1992) Neuronal activity in monkey ventral striatum related to the expectation of reward. J Neurosci 12(12):4595–4610

    PubMed  CAS  Google Scholar 

  61. Evans AH, Pavese N, Lawrence AD, et al. (2006) Compulsive drug use linked to sensitized ventral striatal dopamine transmission. Ann Neurol 59(5):852–858

    PubMed  CAS  Google Scholar 

  62. Colloca L, Lopiano L, Lanotte M, Benedetti F (2004) Overt versus covert treatment for pain, anxiety, and Parkinson’s disease. Lancet Neurol 3(11):679–684

    PubMed  Google Scholar 

  63. Horvitz JC (2000) Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events. Neuroscience 96(4):651–656

    PubMed  CAS  Google Scholar 

  64. Ljungberg T, Apicella P, Schultz W (1992) Responses of monkey dopamine neurons during learning of behavioral reactions. J Neurophysiol 67(1):145–163

    PubMed  CAS  Google Scholar 

  65. Mirenowicz J, Schultz W (1994) Importance of unpredictability for reward responses in primate dopamine neurons. J Neurophysiol 72(2):1024–1027

    PubMed  CAS  Google Scholar 

  66. Montague PR, Dayan P, Sejnowski TJ (1996) A framework for mesencephalic dopamine systems based on predictive Hebbian learning. J Neurosci 16(5):1936–1947

    PubMed  CAS  Google Scholar 

  67. Montague PR, Hyman SE, Cohen JD (2004) Computational roles for dopamine in behavioural control. Nature 431(7010):760–767

    PubMed  CAS  Google Scholar 

  68. Dreher JC, Kohn P, Berman KF (2006) Neural coding of distinct statistical properties of reward information in humans. Cereb Cortex 16(4):561–573

    PubMed  Google Scholar 

  69. Phillips AG, Blaha CD, Fibiger HC (1989) Neurochemical correlates of brain-stimulation reward measured by ex vivo and in vivo analyses. Neurosci Biobehav Rev 13(2–3):99–104

    PubMed  CAS  Google Scholar 

  70. Garris PA, Kilpatrick M, Bunin MA, et al. (1999) Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation. Nature 398(6722):67–69

    PubMed  CAS  Google Scholar 

  71. Phillips PE, Stuber GD, Heien ML, Wightman RM, Carelli RM (2003) Subsecond dopamine release promotes cocaine seeking. Nature 422(6932):614–618

    PubMed  CAS  Google Scholar 

  72. Breiter HC, Rosen BR (1999) Functional magnetic resonance imaging of brain reward circuitry in the human. Ann N Y Acad Sci 877:523–547

    PubMed  CAS  Google Scholar 

  73. Delgado MR, Nystrom LE, Fissell C, Noll DC, Fiez JA (2000) Tracking the hemodynamic responses to reward and punishment in the striatum. J Neurophysiol 84(6):3072–3077

    PubMed  CAS  Google Scholar 

  74. Elliott R, Friston KJ, Dolan RJ (2000) Dissociable neural responses in human reward systems. J Neurosci 20(16):6159–6165

    PubMed  CAS  Google Scholar 

  75. Pagnoni G, Zink CF, Montague PR, Berns GS (2002) Activity in human ventral striatum locked to errors of reward prediction. Nat Neurosci 5(2):97–98

    PubMed  CAS  Google Scholar 

  76. Knutson B, Adams CM, Fong GW, Hommer D (2001) Anticipation of increasing monetary reward selectively recruits nucleus accumbens. J Neurosci 21(16):RC159

    PubMed  CAS  Google Scholar 

  77. Beiter HC, Gollub RL, Weisskoff RM, et al. (1997) Acute effects of cocaine on human brain activity and emotion. Neuron 19(3):591–611

    PubMed  CAS  Google Scholar 

  78. Volkow ND, Wang GJ, Ma Y, et al. (2006) Effects of expectation on the brain metabolic responses to methylphenidate and to its placebo in non-drug abusing subjects. Neuroimage 32(4):1782–1792

    PubMed  Google Scholar 

  79. Knutson B, Westdorp A, Kaiser E, Hommer D (2000) FMRI visualization of brain activity during a monetary incentive delay task. Neuroimage 12(1):20–27

    PubMed  CAS  Google Scholar 

  80. Breiter HC, Aharon I, Kahneman D, Dale A, Shizgal P (2001) Functional imaging of neural responses to expectancy and experience of monetary gains and losses. Neuron 30(2):619–639

    PubMed  CAS  Google Scholar 

  81. Knutson B, Fong GW, Adams CM, Varner JL, Hommer D (2001) Dissociation of reward anticipation and outcome with event-related fMRI. Neuroreport 12(17):3683–3687

    PubMed  CAS  Google Scholar 

  82. Berns GS, McClure SM, Pagnoni G, Montague PR (2001) Predictability modulates human brain response to reward. J Neurosci 21(8): 2793–2798

    PubMed  CAS  Google Scholar 

  83. O’Doherty JP, Deichmann R, Critchley HD, Dolan RJ (2002) Neural responses during anticipation of a primary taste reward. Neuron 33(5):815–826

    PubMed  CAS  Google Scholar 

  84. Risinger RC, Salmeron BJ, Ross TJ, et al. (2005) Neural correlates of high and craving during cocaine self-administration using BOLD fMRI. Neuroimage 26(4):1097–1108

    PubMed  Google Scholar 

  85. Small DM, Jones-Gotman M, Dagher A (2003) Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers. Neuroimage 19(4):1709–1715

    PubMed  Google Scholar 

  86. Barrett SP, Boileau I, Okker J, Pihl RO, Dagher A (2004) The hedonic response to cigarette smoking is proportional to dopamine release in the human striatum as measured by positron emission tomography and [11C]raclopride. Synapse 54(2):65–71

    PubMed  CAS  Google Scholar 

  87. Martinez D, Gil R, Slifstein M, et al. (2005) Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum. Biol Psychiatry 58(10):779–786

    PubMed  CAS  Google Scholar 

  88. Kaasinen V, Aalto S, Nagren K, Rinne JO (2004) Expectation of caffeine induces dopaminergic responses in humans. Eur J Neurosci 19(8):2352–2356

    PubMed  Google Scholar 

  89. Levine JD, Gordon NC, Fields HL (1978) The mechanism of placebo analgesia. Lancet ii:654

    Google Scholar 

  90. Gracely RH, Dubner R, Wolskee PJ, Deeter WR (1983) Placebo and naloxone can alter post-surgical pain by separate mechanisms. Nature 23(306):264–265

    Google Scholar 

  91. Levine JD, Gordon NC (1984) Influence of the method of drug administration on analgesic response. Nature 312(5996):755–756

    PubMed  CAS  Google Scholar 

  92. Benedetti F (1996) The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia. Pain 64(3):535–543

    PubMed  CAS  Google Scholar 

  93. Amanzio M, Benedetti F (1999) Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems. J Neurosci 19(1):484–494

    PubMed  CAS  Google Scholar 

  94. Zubieta JK, Smith YR, Bueller JA, et al. (2001) Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science 293(5528):311–315

    PubMed  CAS  Google Scholar 

  95. Zubieta JK, Bueller JA, Jackson LR, et al. (2005) Placebo effects mediated by endogenous opioid activity on mu-opioid receptors. J Neurosci 25(34):7754–7762

    PubMed  CAS  Google Scholar 

  96. Wager TD, Rilling JK, Smith EE, et al. (2004) Placebo-induced changes in FMRI in the anticipation and experience of pain. Science 303(5661):1162–1167

    PubMed  CAS  Google Scholar 

  97. Voudouris NJ, Peck CL, Coleman G (1989) Conditioned response models of placebo phenomena: further support. Pain 38(1):109–116

    PubMed  CAS  Google Scholar 

  98. Montgomery GH, Kirsch I (1997) Classical conditioning and the placebo effect. Pain 72(1–2):107–113

    PubMed  CAS  Google Scholar 

  99. Price DD, Milling LS, Kirsch I, et al. (1999) An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm. Pain 83(2):147–156

    PubMed  CAS  Google Scholar 

  100. Benedetti F, Mayberg HS, Wager TD, Stohler CS, Zubieta JK (2005) Neurobiological mechanisms of the placebo effect. J Neurosci 25(45):10390–10402

    PubMed  CAS  Google Scholar 

  101. Petrovic P, Kalso E, Petersson KM, Ingvar M (2002) Placebo and opioid analgesia—imaging a shared neuronal network. Science 295(5560):1737–1740

    PubMed  CAS  Google Scholar 

  102. Kong J, Gollub RL, Rosman IS, et al. (2006) Brain activity associated with expectancy-enhanced placebo analgesia as measured by functional magnetic resonance imaging. J Neurosci 26(2):381–388

    PubMed  CAS  Google Scholar 

  103. Benedetti F, Arduino C, Amanzio M (1999) Somatotopic activation of opioid systems by target-directed expectations of analgesia. J Neurosci 19(9):3639–3648

    PubMed  CAS  Google Scholar 

  104. Colloca L, Benedetti F (2005) Placebos and painkillers: is mind as real as matter? Nat Rev Neurosci 6(7):545–552

    PubMed  CAS  Google Scholar 

  105. Walsh BT, Seidman SN, Sysko R, Gould M (2002) Placebo response in studies of major depression: variable, substantial, and growing. JAMA 287(14):1840–1847

    PubMed  Google Scholar 

  106. Mayberg HS, Silva JA, Brannan SK, et al.(2002) The functional neuroanatomy of the placebo effect. Am J Psychiatry 159(5):728–737

    PubMed  Google Scholar 

  107. Kirsch I, Sapierstein G (1998) Listening to Prozac but hearing placebo: a meta-analysis of antidepressant medications. Prev Treat 1(6):2a

    Google Scholar 

  108. Mayberg HS, Brannan SK, Tekell JL, et al. (2000) Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biol Psychiatry 48(8):830–843

    PubMed  CAS  Google Scholar 

  109. Leuchter AF, Cook IA, Witte EA, Morgan M, Abrams M (2002) Changes in brain function of depressed subjects during treatment with placebo. Am J Psychiatry 159(1):122–129

    PubMed  Google Scholar 

  110. Hunter AM, Leuchter AF, Morgan ML, Cook IA (2006) Changes in brain function (quantitative EEG cordance) during placebo lead-in and treatment outcomes in clinical trials for major depression. Am J Psychiatry 163(8):1426–1432

    PubMed  Google Scholar 

  111. Lidstone SC, de la Fuente-Fernandez R, Stoessl AJ (2005) The placebo response as a reward mechanism. Semin Pain Med 4(1):37–42

    Google Scholar 

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  1. Pacific Parkinson’s Research Centre and Graduate Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada

    Sarah C. Christine Lidstone

  2. Pacific Parkinson’s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada

    A. Jon Stoessl

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Correspondence to A. Jon Stoessl.

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An erratum to this article is available at http://dx.doi.org/10.1007/s11307-007-0098-z.

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Lidstone, S.C.C., Stoessl, A.J. Understanding the Placebo Effect: Contributions from Neuroimaging. Mol Imaging Biol 9, 176–185 (2007). https://doi.org/10.1007/s11307-007-0086-3

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