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First published October 2003

Prefrontal DA Transmission at D1 Receptors and the Pathology of Schizophrenia

Anissa Abi-Dargham and Holly MooreView all authors and affiliations
Volume 9, Issue 5
https://doi.org/10.1177/1073858403252674

Abstract

The current view on the dopamine (DA) hypothesis of schizophrenia postulates a cortical/subcortical imbalance: subcortical mesolimbic DA projections might be hyperactive, resulting in hyperstimulation of D2receptors and positive symptoms, whereas mesocortical DA projections to the prefrontal cortex might be hypoactive, resulting in hypostimulation of D1 receptors, negative symptoms, and cognitive impairment. Although the subcortical abnormalities are relatively well established now, the evidence for cortical hypodopaminergia is just emerging. This article will review current evidence for prefrontal hypodopaminergia in schizophrenia, with special emphasis on positron emission tomography (PET) studies measuring cortical D1 receptors in schizophrenia. The presentation of the clinical data will be introduced by a brief overview of the function of prefrontal DA systems, both at the cellular and cognitive level. The impact of antipsychotic drugs on prefrontal DA function will also be reviewed. We will conclude with the formulation of several models of altered prefrontal DA transmission at D1 receptors in schizophrenia.

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References

Abi-Dargham A, Martinez D, Mawlawi O, Simpson N, Hwang DR, Slifstein M, and others. 2000. Measurement of striatal and extrastriatal dopamine D1 receptor binding potential with [11C]NNC 112 in humans: validation and reproducibility . J Cereb Blood Flow Metab 20: 225-243 .
Google Scholar
Abi-Dargham A, Mawlawi O, Lombardo I, Gil R, Martinez D, Huang Y, and others. 2002. Prefrontal dopamine D1 receptors and working memory in schizophrenia . J Neurosci 22: 3708-3719 .
Google Scholar
Abi-Dargham A, Simpson N, Kegeles L, Parsey R, Hwang DR, Anjilvel S, and others. 1999. PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756 . Synapse 32: 93-109 .
Google Scholar
Ahlenius S. 1999. Clozapine: dopamine D1 receptor agonism in the prefrontal cortex as the code to decipher a Rosetta stone of antipsychotic drugs . Pharmacol Toxicol 84: 193-196 .
Google Scholar
Akil M, Pierri JN, Whitehead RE, Edgar CL, Mohila C, Sampson AR, and others. 1999. Lamina-specific alterations in the dopamine innervation of the prefrontal cortex in schizophrenic subjects . Am J Psychiatry 156: 1580-1589 .
Google Scholar
Andersen PH, Gronvald FC, Hohlweg R, Hansen LB, Guddal E, Braestrup C, and others. 1992. NNC-112, NNC-687 and NNC-756, new selective and highly potent dopamine D1 receptor antagonists . Eur J Pharmacol 219: 45-52 .
Google Scholar
Angrist B, van Kammen DP. 1984. CNS stimulants as a tool in the study of schizophrenia . Trends Neurosci 7: 388-390 .
Google Scholar
Arnsten AF. 1997. Catecholamine regulation of the prefrontal cortex . J Psychopharmacol 11: 151-162 .
Google Scholar
Arnsten AF, Cai JX, Murphy BL, Goldman-Rakic PS. 1994. Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys . Psychopharmacology 116: 143-151 .
Google Scholar
Arnsten AF, Goldman-Rakic PS. 1990. Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch- to-sample performance of aged rhesus monkeys . Neurobiol Aging 11: 583-590 .
Google Scholar
Bowen F, Kamienny R, Burn M, Yahr N. 1975. Parkinsonism: effect of levodopa treatment on concept formation . Neurology 25: 701-704 .
Google Scholar
Brozoski TJ, Brown RM, Rosvold HE, Goldman PS. 1979. Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey . Science 205: 929-932 .
Google Scholar
Cai JX, Arnsten AFT. 1997. Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys . J Pharmacol Exp Ther 283: 183-189 .
Google Scholar
Carlsson A, Lindqvist M. 1963. Effect of chlorpromazine or haloperi-dol on formation of 3-methoxytyramine and normetanephrine in mouse brain . Acta Pharmacol Toxicol 20: 140-144 .
Google Scholar
Castner SA, Williams GV, Goldman-Rakic PS. 2000a. Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation [see comments] . Science 287: 2020-2022 .
Google Scholar
Castner SA, Williams GV, Goldman-Rakic PS. 2000b. Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation . Science 287: 2020-2022 .
Google Scholar
Cepeda C, Radisavljevic Z, Peacock W, Levine MS, Buchwald NA. 1992. Differential modulation by dopamine of responses evoked by excitatory amino acids in human cortex . Synapse 11: 330-341 .
Google Scholar
Chou YH, Karlsson P, Halldin C, Olsson H, Farde L. 1999. A PET study of D1 -like dopamine receptor ligand binding during altered endogenous dopamine levels in the primate brain . Psychopharmacology 146: 220-227 .
Google Scholar
Cooper JR, Bloom FE, Roth RH. 2002. The biochemical basis of neuropharmacology. New York: Oxford University Press .
Google Scholar
Creese I, Burt DR, Snyder SH. 1976. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs . Science 19: 481-483 .
Google Scholar
Cumming P, Gjedde A. 1998. Compartmental analysis of dopa decar-boxylation in living brain from dynamic positron emission tomograms . Synapse 29: 37-61 .
Google Scholar
Daniel DG, Weinberger DR, Jones DW, Zigun JR, Coppola R, Handel S, and others. 1991. The effect of amphetamine on regional cerebral blood flow during cognitive activation in schizophrenia . J Neurosci 11: 1907-1917 .
Google Scholar
Davis KL, Kahn RS, Ko G, Davidson M. 1991. Dopamine in schizophrenia: a review and reconceptualization . Am J Psychiatry 148: 1474-1486 .
Google Scholar
de Beaurepaire R, Labelle A, Naber D, Jones BD, Barnes TR. 1995. An open trial of the D1 antagonist SCH 39166 in six cases of acute psychotic states . Psychopharmacology (Berl) 121: 323-327 .
Google Scholar
Del Arco A, Mora F. 2000. Endogenous dopamine potentiates the effects of glutamate on extracellular GABA in the prefrontal cortex of the freely moving rat . Brain Res Bull 53: 339-345 .
Google Scholar
Den Boer JA, van Megen HJ, Fleischhacker WW, Louwerens JW, Slaap BR, Westenberg HG, and others. 1995. Differential effects of the D1 -DA receptor antagonist SCH39166 on positive and negative symptoms of schizophrenia . Psychopharmacology (Berl) 121: 317-322 .
Google Scholar
Deutch A, Clark WA, Roth RH. 1990. Prefrontal cortical dopamine depletion enhances the responsiveness of the mesolimbic dopamine neurons to stress . Brain Res 521: 311-315 .
Google Scholar
Dolan RJ, Fletcher P, Frith CD, Friston KJ, Frackowiak RS, Grasby PM. 1995. Dopaminergic modulation of impaired cognitive activation in the anterior cingulate cortex in schizophrenia . Nature 378: 180-182 .
Google Scholar
Dumartin B, Jaber M, Gonon F, Caron MG, Giros B, Bloch B. 2000. Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice . Proc Natl Acad Sci U S A 97: 1879-1884 .
Google Scholar
Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, and others. 2001. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia . Proc Natl Acad Sci U S A 98: 6917-6922 .
Google Scholar
Farde L. 1992. Selective D1 - and D2-dopamine receptor blockade both induces akathisia in humans—a PET study with [11C]SCH 23390 and [11C]raclopride . Psychopharmacology (Berl) 107: 23-29 .
Google Scholar
Farde L, Suhara T, Nyberg S, Karlsson P, Nakashima Y, Hietala J, and others. 1997. A PET study of [C-11]FLB 457 binding to extrastriatal D-2-dopamine receptors in healthy subjects and antipsychotic drug-treated patients . Psychopharmacology 133: 396-404 .
Google Scholar
Fienberg AA, Hiroi N, Mermelstein PG, Song W, Snyder GL, Nishi A, and others. 1998. DARPP-32: regulator of the efficacy of dopaminergic neurotransmission . Science 281: 838-842 .
Google Scholar
Gao WJ, Krimer LS, Goldman-Rakic PS. 2001. Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits . Proc Natl Acad Sci U S A 98: 295-300 .
Google Scholar
Gessa GL, Devoto P, Diana M, Flore G, Melis M, Pistis M. 2000. Dissociation of haloperidol, clozapine, and olanzapine effects on electrical activity of mesocortical dopamine neurons and dopamine release in the prefrontal cortex . Neuropsychopharmacology 22: 642-649 .
Google Scholar
Gogos JA, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D, and others. 1998. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior . Proc Natl Acad Sci U S A 95: 9991-9996 .
Google Scholar
Goldman-Rakic PS, Muly EC 3rd, Williams GV. 2000. D(1) receptors in prefrontal cells and circuits . Brain Res Brain Res Rev 31: 295-301 .
Google Scholar
Gorelova N, Seamans JK, Yang CR. 2002. Mechanisms of dopamine activation of fast-spiking interneurons that exert inhibition in rat prefrontal cortex . J Neurophysiol 88: 3150-3166 .
Google Scholar
Grace AA. 1991. Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia . Neuroscience 41: 1-24 .
Google Scholar
Grace AA. 1993. Cortical regulation of subcortical systems and its possible relevance to schizophrenia . J Neural Transm 91: 111-134 .
Google Scholar
Grobin AC, Deutch AY. 1998. Dopaminergic regulation of extracellular gamma-aminobutyric acid levels in the prefrontal cortex of the rat . J Pharmacol Exp Ther 285: 350-357 .
Google Scholar
Guo N, Hwang D, Abdellhadi S, Abi-Dargham A, Zarahn E, Laruelle M. 2001. The effect of chronic DA depletion on D1 ligand binding in rodent brain . Soc Neurosci Abstr 27.
Google Scholar
Gurden H, Takita M, Jay TM. 2000. Essential role of D1 but not D2 receptors in the NMDA receptor-dependent long-term potentiation at hippocampal-prefrontal cortex synapses in vivo . J Neurosci 20: RC106 .
Google Scholar
Haber SN, Fudge JL. 1997. The primate substantia nigra and VTA: integrative circuitry and function . Crit Rev Neurobiol 11: 323-342 .
Google Scholar
Hall H, Sedvall G, Magnusson O, Kopp J, Halldin C, Farde L. 1994. Distribution of D1 - and D2 -dopamine receptors, and dopamine and its metabolites in the human brain . Neuropsychopharmacology 11: 245-256 .
Google Scholar
Halldin C, Foged C, Chou YH, Karlsson P, Swahn CG, Sandell J, and others. 1998. Carbon-11-NNC 112: a radioligand for PET examination of striatal and neocortical D1 -dopamine receptors . J Nucl Med 39: 2061-2068 .
Google Scholar
Halldin C, Stone-Elander S, Farde L, Ehrin E, Fasth KJ, Langström B, and others. 1986. Preparation of 11C-labelled SCH 23390 for the in vivo study of dopamine D1 receptors using positron emission tomography . Appl Radiat Isot 37: 1039-1043 .
Google Scholar
Henze DA, Gonzalez-Burgos GR, Urban NN, Lewis DA, Barrionuevo G. 2000. Dopamine increases excitability of pyramidal neurons in primate prefrontal cortex . J Neurophysiol 84: 2799-2809 .
Google Scholar
Hirvonen J, Nagren K, Kajander J, Hietala J. 2001. Measurement of cortical dopamine D1 receptor binding with 11C[SCH23390]: a test-retest analysis . J Cereb Blood Flow Metab 21: 1133-1145 .
Google Scholar
Ichikawa J, Ishii H, Bonaccorso S, Fowler WL, O'Laughlin IA, Meltzer HY. 2001. 5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release . J Neurochem 76: 1521-1531 .
Google Scholar
Jackson DM, Wikstrom H, Liao Y. 1998. Is clozapine an (partial) agonist at both dopamine D1 and D2 receptors? Psychopharmacology (Berl) 138: 213-216 .
Google Scholar
Javitt DC, Zukin SR. 1991. Recent advances in the phencyclidine model of schizophrenia . Am J Psychiatry 148: 1301-1308 .
Google Scholar
Jentsch JD, Roth RH. 1999. The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia . Neuropsychopharmacology 20: 201-225 .
Google Scholar
Joyce JN, Meador-Woodruff JH. 1997. Linking the family of D-2 receptors to neuronal circuits in human brain: insights into schizo-phrenia . Neuropsychopharmacology 16: 375-384 .
Google Scholar
Kahn RS, Harvey PD, Davidson M, Keefe RS, Apter S, Neale JM, and others. 1994. Neuropsychological correlates of central monoamine function in chronic schizophrenia: relationship between CSF metabolites and cognitive function . Schizophr Res 11: 217-224 .
Google Scholar
Kakiuchi T, Nishiyama S, Sato K, Ohba H, Nakanishi S, Tsukada H. 2001. Effect of MK801 on dopamine parameters in the monkey brain . Neuroimage 16: 110 .
Google Scholar
Karle J, Clemmesen L, Hansen L, Andersen M, Andersen J, Fensbo C, and others. 1995. NNC 01-0687, a selective dopamine D1 receptor antagonist, in the treatment of schizophrenia . Psychopharmacology (Berl) 121: 328-329 .
Google Scholar
Karlsson P, Farde L, Halldin C, Sedvall G. 2002. PET study of D(1) dopamine receptor binding in neurolepticnaive patients with schizophrenia . Am J Psychiatry 159: 761-767 .
Google Scholar
Karlsson P, Smith L, Farde L, Harnryd C, Sedvall G, Wiesel FA. 1995. Lack of apparent antipsychotic effect of the D1 -dopamine receptor antagonist SCH39166 in acutely ill schizophrenic patients . Psychopharmacology (Berl) 121: 309-316 .
Google Scholar
Karreman M, Moghaddam B. 1996. The prefrontal cortex regulates the basal release of dopamine in the limbic striatum: an effect mediated by ventral tegmental area . J Neurochem 66: 589-598 .
Google Scholar
Knable MB, Hyde TM, Murray AM, Herman MM, Kleinman JE. 1996. A postmortem study of frontal cortical dopamine D1 receptors in schizophrenics, psychiatric controls, and normal controls . Biol Psychiatry 40: 1191-1199 .
Google Scholar
Knable MB, Weinberger DR. 1997. Dopamine, the prefrontal cortex and schizophrenia . J Psychopharmacol 11: 123-131 .
Google Scholar
Kolachana BS, Saunders R, Weinberger D. 1995. Augmentation of prefrontal cortical monoaminergic activity inhibits dopamine release in the caudate nucleus: an in vivo neurochemical assessment in the rhesus monkey . Neurosciences 69: 859-868 .
Google Scholar
Konradi C, Leveque JC, Hyman SE. 1996. Amphetamine and dopamine-induced immediate early gene expression in striatal neurons depends on postsynaptic NMDA receptors and calcium . J Neurosci 16: 4231-4239 .
Google Scholar
Kornhuber J, Brücke T, Angelberger P, Asenbaum S, Podreka I. 1995. SPECT imaging of dopamine receptors with [123I]epidepride: characterization of uptake in the human brain . J Neural Transm Gen Sect 101: 95-103 .
Google Scholar
Laruelle M. 2000b. Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review . J Cereb Blood Flow Metab 20: 423-451 .
Google Scholar
Laruelle M, Casanova M, Weinberger D, Kleinman J. 1990. Postmortem study of the dopaminergic D1 receptors in the dorsolateral prefrontal cortex of schizophrenics and controls . Schizophrenia Res 3: 30-31 .
Google Scholar
Laruelle M, Sidhu A, Casanova MF, Weinberger DR, Kleinman JE. 1991. Characterization of [125I]SCH23982 binding in human brain: comparison with [3H]SCH23390 . Neurosci Lett 31: 273-276 .
Google Scholar
Laruelle M, Slifstein M, Huang Y. 2002. Positron emission tomography: imaging and quantification of neurotransporter availability . Methods 27: 287-299 .
Google Scholar
Lavin A, Grace AA. 2001. Stimulation of D1 -type dopamine receptors enhances excitability in prefrontal cortical pyramidal neurons in a state-dependent manner . Neuroscience 104: 335-346 .
Google Scholar
Lezcano N, Bergson C. 2002. D1 /D5 dopamine receptors stimulate intracellular calcium release in primary cultures of neocortical and hippocampal neurons . J Neurophysiol 87: 2167-2175 .
Google Scholar
Lidow MS, Elsworth JD, Goldman Rakic PS. 1997. Down-regulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs . J Pharmacol Exp Ther 281: 597-603 .
Google Scholar
Lidow MS, Goldman-Rakic PS. 1994. A common action of clozapine, haloperidol, and remoxipride on D1 - and D2 -dopaminergic receptors in the primate cerebral cortex . Proc Natl Acad Sci U S A 91: 4353-4356 .
Google Scholar
Lieberman JA, Kane JM, Alvir J. 1987. Provocative tests with psychostimulant drugs in schizophrenia . Psychopharmacology 91: 415-433 .
Google Scholar
Logan J, Fowler JS, Dewey SL, Volkow ND, Gatley SJ. 2001. A consideration of the dopamine D2 receptor monomer-dimer equilibrium and the anomalous binding properties of the dopamine D2receptor ligand, N-methyl spiperone . J Neural Transm 108: 279-286 .
Google Scholar
Mattay VS, Callicott JH, Bertolino A, Heaton I, Frank JA, Coppola R, and others. 2000. Effects of dextroamphetamine on cognitive performance and cortical activation . Neuroimage 12: 268-275 .
Google Scholar
Meador-Woodruff JH, Haroutunian V, Powchik P, Davidson M, Davis KL, Watson SJ. 1997. Dopamine receptor transcript expression in striatum and prefrontal and occipital cortex. Focal abnormalities in orbitofrontal cortex in schizophrenia . Arch Gen Psychiatry 54: 1089-1095 .
Google Scholar
Mehta MA, Owen AM, Sahakian BJ, Mavaddat N, Pickard JD, Robbins TW. 2000. Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain . J Neurosci (Online) 20: RC65 .
Google Scholar
Memo M, Pizzi M, Missale C, Carruba MO, Spano PF. 1987. Modification of the function of D1 and D2 dopamine receptors in striatum and nucleus accumbens of rats chronically treated with haloperidol . Neuropharmacology 26: 477-480 .
Google Scholar
Memo M, Pizzi M, Nisoli E, Missale C, Carruba MO, Spano P. 1987. Repeated administration of (-)sulpiride and SCH 23390 differentially up-regulate D-1 and D-2 dopamine receptor function in rat mesostriatal areas but not in cortical-limbic brain regions . Eur J Pharmacol 138: 45-51 .
Google Scholar
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG. 1998. Dopamine receptors: from structure to function . Physiol Rev 78: 189-225 .
Google Scholar
Mogenson GJ, Jones DL, Yim CY. 1980. From motivation to action: functional interface between the limbic system and the motor system . Prog Neurobiol 14: 69-97 .
Google Scholar
Mrzljak L, Bergson C, Pappy M, Huff R, Levenson R, Goldman-Rakic PS. 1996. Localization of dopamine D4 receptors in GABAergic neurons of the primate brain . Nature 381: 245-248 .
Google Scholar
Mukherjee J, Christian BT, Dunigan KA, Shi B, Narayanan TK, Satter M, and others. 2002. Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors . Synapse 46: 170-188 .
Google Scholar
Murphy BL, Arnsten AF, Goldman-Rakic PS, Roth RH. 1996. Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys . Proc Natl Acad Sci U S A 93: 1325-1329 .
Google Scholar
Murphy BL, Arnsten AF, Jentsch JD, Roth RH. 1996. Dopamine and spatial working memory in rats and monkeys: pharmacological reversal of stress-induced impairment . J Neurosci 16: 7768-7775 .
Google Scholar
Narendran R, Talbot PS, Slifstein M, Sudo Y, Guo N, Hackett E, and others. 2002. Effects of d-amphetamine on the binding of [18F] fallypride in striatal and extrastriatal regions in baboons: single bolus and bolus plus constant infusion studies . J Nuc Med 43: 106P .
Google Scholar
Ninan I, Kulkarni SK. 1998. Partial agonistic action of clozapine at dopamine D2 receptors in dopamine depleted animals . Psychopharmacology (Berl) 135: 311-317 .
Google Scholar
Nordstrom AL, Farde L, Nyberg S, Karlsson P, Halldin C, Sedvall G. 1995. D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients . Am J Psychiatry 152: 1444-1449 .
Google Scholar
Okubo Y, Suhara T, Suzuki K, Kobayashi K, Inoue O, Terasaki O, and others. 1997. Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET . Nature 385: 634-636 .
Google Scholar
Porceddu ML, Ongini E, Biggio G. 1985. [3H]SCH 23390 binding sites increase after chronic blockade of D-1 dopamine receptors . Eur J Pharmacol 118: 367-370 .
Google Scholar
Pycock CJ, Kerwin RW, Carter CJ. 1980. Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats . Nature 286: 74-77 .
Google Scholar
Rollema H, Lu Y, Schmidt AW, Zorn SH. 1997. Clozapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation . Eur J Pharmacol 338: R3-R5 .
Google Scholar
Sawaguchi T, Goldman-Rakic PS. 1991. D1 dopamine receptors in prefrontal cortex: involvement in working memory . Science 251: 947-950 .
Google Scholar
Sawaguchi T, Goldman-Rakic PS. 1994. The role of D1 -dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task . J Neurophysiol 71: 515-528 .
Google Scholar
Schneider JS, Sun ZQ, Roeltgen DP. 1994. Effects of dopamine agonists on delayed response performance in chronic low-dose MPTP-treated monkeys . Pharmacol Biochem Behav 48: 235-240 .
Google Scholar
Scott L, Kruse MS, Forssberg H, Brismar H, Greengard P, Aperia A. 2002. Selective up-regulation of dopamine D1 receptors in dendritic spines by NMDA receptor activation . Proc Natl Acad Sci U S A 99: 1661-1664 .
Google Scholar
Seamans JK, Floresco SB, Phillips AG. 1998. D-1 receptor modulation of hippocampal-prefrontal cortical circuits integrating spatial memory with executive functions in the rat . J Neurosci 18: 1613-1621 .
Google Scholar
Seamans JK, Gorelova N, Durstewitz D, Yang CR. 2001. Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons . J Neurosci 21: 3628-3638 .
Google Scholar
Seeman P. 1992. Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4 . Neuropsychopharmacology 7: 261-284 .
Google Scholar
Seeman P, Lee T. 1975. Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons . Science 188: 1217-1219 .
Google Scholar
Smiley JF, Levey AI, Ciliax BJ, Goldman-Rakic PS. 1994. D1 dopamine receptor immunoreactivity in human and monkey cerebral cortex: predominant and extrasynaptic localization in dendritic spines . Proc Natl Acad Sci U S A 91: 5720-5724 .
Google Scholar
Stern Y, Langston JW. 1985. Intellectual changes in patients with MPTP-induced parkinsonism . Neurology 35: 1506-1509 .
Google Scholar
Suhara T, Nakayama K, Inoue O, Fukuda H, Shimizu M, Mori A, and others. 1992. D1 dopamine receptor binding in mood disorders measured by positron emission tomography . Psychopharmacology (Berl) 106: 14-18 .
Google Scholar
Tzschentke TM. 2001. Pharmacology and behavioral pharmacology of the mesocortical dopamine system . Prog Neurobiol 63: 241-320 .
Google Scholar
Urban NN, Gonzalez-Burgos G, Henze DA, Lewis DA, Barrionuevo G. 2002. Selective reduction by dopamine of excitatory synaptic inputs to pyramidal neurons in primate prefrontal cortex . J Physiol 539: 707-712 .
Google Scholar
Verhoeff NP, Hussey D, Lee M, Tauscher J, Papatheodorou G, Wilson AA, and others. 2002. Dopamine depletion results in increased neostriatal D(2), but not D(1), receptor binding in humans . Mol Psychiatry 7: 233, 322-338 .
Google Scholar
Watanabe M, Kodama T, Hikosaka K. 1997. Increase of extracellular dopamine in primate prefrontal cortex during a working memory task . J Neurophysiol 78: 2795-2798 .
Google Scholar
Weinberger DR. 1987. Implications of the normal brain development for the pathogenesis of schizophrenia . Arch Gen Psychiatry 44: 660-669 .
Google Scholar
Weinberger DR, Berman KF, Chase TN. 1988. Mesocortical dopaminergic function and human cognition . Ann N Y Acad Sci 537: 330-338 .
Google Scholar
Weinberger DR, Laruelle M. 2001. Neurochemical and neuropharmacological imaging in schizophrenia. In: Davis KL, Charney DS, Coyle JT, Nemeroff C, editors. Neuropharmacology—the fifth generation of progress. Philadelphia: Lippincott, Williams, and Wilkins p. 833-855.
Google Scholar
Westerink BH, Kawahara Y, De Boer P, Geels C, De Vries JB, Wikstrom HV, and others. 2001. Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum . Eur J Pharmacol 412: 127-138 .
Google Scholar
Wilkinson LS. 1997. The nature of interactions involving prefrontal and striatal dopamine systems . J Psychopharmacol 11: 143-150 .
Google Scholar
Yamamoto BK, Cooperman MA. 1994. Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations . J Neurosci 14: 4159-4166 .
Google Scholar
Yang CR, Seamans JK, Gorelova N. 1999. Developing a neuronal model for the pathophysiology of schizophrenia based on the nature of electrophysiological actions of dopamine in the prefrontal cortex . Neuropsychopharmacology 21: 161-194 .
Google Scholar
Youngren KD, Inglis FM, Pivirotto PJ, Jedema HP, Bradberry CW, Goldman-Rakic PS, and others. 1999. Clozapine preferentially increases dopamine release in the rhesus monkey prefrontal cortex compared with the caudate nucleus . Neuropsychopharmacology 20: 403-412 .
Google Scholar
Zahrt J, Taylor JR, Mathew RG, Arnsten AFT. 1997a. Supranormal stimulation of D-1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance . J Neurosci 17: 8528-8535 .
Google Scholar

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Published In

Volume 9, Issue 5
Pages: 404 - 416
Article first published: October 2003
Issue published: October 2003

Keywords

  1. Schizophrenia
  2. DLPFC
  3. D1 receptors
  4. Dopamine
  5. PET

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PubMed: 14580124

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Anissa Abi-Dargham
Departments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, [email protected]
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Holly Moore
Departments of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google ScholarPub Med
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google ScholarPub Med
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google ScholarPub Med
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    Go to citation Crossref Google ScholarPub Med
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar
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    Go to citation Crossref Google Scholar

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