Abstract
The mechanisms responsible for the production of major extrapyramidal side-effects (parkinsonism, akathisia, acute dystonic reactions, chronic tardive dyskinesias) are reviewed in the light of the complex effects of these drugs on cerebral dopamine systems.
MeSH terms
- Antipsychotic Agents / adverse effects*
- Basal Ganglia Diseases / chemically induced*
- Corpus Striatum / drug effects
- Dopamine / metabolism
- Dopamine / physiology
- Dyskinesia, Drug-Induced / etiology
- Dystonia / chemically induced
- Humans
- Parkinson Disease, Secondary / chemically induced
- Receptors, Dopamine / drug effects
- Stereotyped Behavior / drug effects
- Substance Withdrawal Syndrome / etiology
- Sympatholytics / pharmacology
Substances
- Antipsychotic Agents
- Receptors, Dopamine
- Sympatholytics
- Dopamine