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What is a Gene? A Two Sided View

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References

  • Avery, O. T., MacLeod, C. M., & McCarty, M. (1944). Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Induction of transformation by a desoxyribonucleic acid fraction isolated from Pneumococcus type III. Journal of Experimental Medicine, 79, 137–158.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Beadle, G. W., & Tatum, E. L. (1941). Genetic control of biochemical reactions in Neurospora. Proceedings of the National Academy of Science USA, 27, 499–506.

    Article  CAS  Google Scholar 

  • Blaze, J., & Roth, T. L. (2015). Evidence from clinical and animal model studies of the long-term and transgenerational impact of stress on DNA methylation. Seminars in Cell & Developmental Biology, 43, 76–84.

    Article  CAS  Google Scholar 

  • Chow, L. T., Gelinas, R. E., Broker, T. R., & Roberts, R. J. (1977). An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA. Cell, 12, 1–8.

    Article  CAS  PubMed  Google Scholar 

  • Cohen, S. N. (1976). Transposable genetic elements and plasmid evolution. Nature, 263, 731–738.

    Article  CAS  PubMed  Google Scholar 

  • Davidson, E. H., & Britten, R. J. (1973). Organization, transcription, and regulation in the animal genome. Quarterly Review of Biology, 48, 565–613.

    Article  CAS  PubMed  Google Scholar 

  • Feil, R., & Fraga, M. F. (2012). Epigenetics and the environment: Emerging patterns and implications. Nature Reviews Genetics, 13, 97–109.

    CAS  PubMed  Google Scholar 

  • Hershey, A. D., & Chase, M. (1952). Independent functions of viral protein and nucleic acid in growth of bacteriophage. Journal of General Physiology, 36, 39–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Horowitz, M., Bratosin, S., & Aloni, Y. (1978). Polyoma infected cells contain at least three spliced late RNAs. Nucleic Acids Research, 5, 4663–4675.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jacob, F., & Monod, J. (1961). Molecular and biological characterization of messenger RNA. Journal of Molecular Biology, 3, 318–356.

    Article  CAS  PubMed  Google Scholar 

  • Jensen, T. H., Jacquier, A., & Libri, D. (2013). Dealing with pervasive transcription. Molecular Cell, 52, 473–484.

    Article  CAS  PubMed  Google Scholar 

  • Johannsen, W. (1909). Elemente der exakten erblichkeitslehre (pp. 143–144). Gustav Fischer: Jena.

    Google Scholar 

  • Keller, E. F. (2000). The century of the gene. Cambridge, MA: Harvard University Press.

    Google Scholar 

  • Kouzarides, T. (2007). Chromatin modifications and their function. Cell, 128, 693–705.

    Article  CAS  PubMed  Google Scholar 

  • McClintock, B. (1947). Cytogenetic studies of maize and Neurospora. Carnegie Institute Washington Yearbook, 46, 146–152.

    Google Scholar 

  • Normark, S., Bergström, S., Edlund, T., Grundström, T., Jaurin, B., Lindberg, F. P., et al. (1983). Overlapping genes. Annual Review of Genetics, 17, 499–525.

    Article  CAS  PubMed  Google Scholar 

  • Pacchierotti, F., & Spanò, M. (2015). Environmental impact on DNA methylation in the germline: State of the art and gaps of knowledge. BioMed Research International, 2015, Article ID 123484.

  • Portin, P. (2002). Historical development of the concept of the gene. Journal of Medicine and Philosophy, 27, 257–286.

    Article  PubMed  Google Scholar 

  • Roth, T. L. (2013). Epigenetic mechanisms in the development of behavior: Advances, challenges, and future promises of a new field. Development and Psychopathology, 25, 1279–1291.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schrey, A. W., Coon, C. A., Grispo, M. T., Awad, M., Imboma, T., McCoy, E. D., et al. (2012). Epigenetic variation may compensate for decreased genetic variation with introductions: A case study using house sparrows (Passer domesticus) on two continents. Genetics Research International, 2012, article ID 979751.

  • Schübeler, D. (2015). Function and information content of DNA methylation. Nature, 517, 321–326.

    Article  PubMed  Google Scholar 

  • Schuster, S. C. (2008). Next-generation sequencing transforms today’s biology. Nature Methods, 5, 16–18.

    Article  CAS  PubMed  Google Scholar 

  • Waddington, C. H. (1942). The epigenotype. Endeavor, 1, 18–20.

    Google Scholar 

  • Watson, J. D., & Crick, F. H. C. (1953). A structure for deoxyribonucleic acid. Nature, 171, 737–738.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was partially supported by the Istituto Pasteur-Fondazione Cenci Bolognetti (Università di Roma La Sapienza) and by the Epigenomics Flagship Project EpiGen (Italian Ministry of Education and Research, National Research Council).

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Authors and Affiliations

  1. Dipartimento di Biologia e Biotecnologie, Sapienza, Università di Roma, Piazzale A. Moro 5, 00185, Rome, Italy

    A. Bolondi, F. Caldarelli, F. Di Felice, D. Durano, G. Germani, L. Michetti, A. Tramutolo & G. Camilloni

  2. Istituto di Biologia e Patologia Molecolari, CNR, Piazzale A. Moro 5, 00185, Rome, Italy

    G. Micheli & G. Camilloni

  3. Istituto Pasteur Italia - Fondazione Cenci Bolognetti e Dipartimento di Biologia e Biotecnologie, Sapienza - Università di Roma, Piazzale A. Moro 5, 00185, Rome, Italy

    G. Camilloni

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  1. A. Bolondi
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Bolondi, A., Caldarelli, F., Di Felice, F. et al. What is a Gene? A Two Sided View. Evol Biol 44, 1–4 (2017). https://doi.org/10.1007/s11692-016-9392-5

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