Psychiatric manifestations of latent toxoplasmosis. Potential mediation by indoleamine 2,3-dioxygenase

Abstract

Toxoplasma gondii, a prevalent neurotropic parasite, induces immunological reactions that have the potential to affect brain and behavior. One possible connection between molecular mediators of inflammation (cytokines) and brain function and behavior is the activation of the enzyme indole-amine 2,3-dioxygenase, a mechanism implicated in containing T. gondii in the immunocompetent host, resulting in relative tryptophan depletion and kynurenine production. This could potentially lead to mood and behavioral dysregulation in latent toxoplasmosis.