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Critical Reviews™ in Neurobiology

Published 3 issues per year

ISSN Print: 0892-0915

ISSN Online: 2375-0014

SJR: 0.121

The Primate Substantia Nigra and VTA: Integrative Circuitry and Function

Volume 11, Issue 4, 1997, pp. 323-342
DOI: 10.1615/CritRevNeurobiol.v11.i4.40
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ABSTRACT

A substantial amount of research has focused on the midbrain dopamine system and its role in mediating a wide range of behaviors. In diseases in which dopamine function is compromised, patients exhibit a constellation of symptoms suggesting that the dopamine system plays an important role in the integration of several functions. We have shown that there are subgroups of dopamine neurons that receive information from limbic and association areas and project widely throughout cortex and striatum, including motor areas. A dorsal tier of dopamine neurons receive input from the ventral (limbic) striatum and the amygdala and project widely throughout cortex. A more ventrally located group of dopamine cells receives input from both the limbic and association areas of striatum and project widely throughout the striatum including the sensorimotor regions. Through these projections the dopamine system can effect a wide range of behaviors. For the most part, structures of the basal ganglia are thought to be organized in parallel pathways. However, the behaviors affected by basal ganglia disorders can be in part explained by the integrative nature of the dopamine system and its links to motor, limbic, and association areas of the striatum and cortex.

CITED BY
  1. Tobler Philippe N., Kobayashi Shunsuke, Electrophysiological correlates of reward processing in dopamine neurons, in Handbook of Reward and Decision Making, 2009. Crossref

  2. ALHEID GEORGE F., SHAMMAH-LAGNADO SARA J., BELTRAMINO CARLOS A., The Interstitial Nucleus of the Posterior Limb of the Anterior Commissure: A Novel Layer of the Central Division of Extended Amygdala, Annals of the New York Academy of Sciences, 877, 1 ADVANCING FRO, 1999. Crossref

  3. Tomasi D., Volkow N. D., Functional Connectivity of Substantia Nigra and Ventral Tegmental Area: Maturation During Adolescence and Effects of ADHD, Cerebral Cortex, 24, 4, 2014. Crossref

  4. Chen Sheng, Lu Frances Fangjia, Seeman Philip, Liu Fang, Quantitative Proteomic Analysis of Human Substantia Nigra in Alzheimer’s Disease, Huntington’s Disease and Multiple Sclerosis, Neurochemical Research, 37, 12, 2012. Crossref

  5. Plowman Emily K., Maling Nicholas, Rivera Benjamin J., Larson Krista, Thomas Nagheme J., Fowler Stephen C., Manfredsson Fredric P., Shrivastav Rahul, Kleim Jeffrey A., Differential sensitivity of cranial and limb motor function to nigrostriatal dopamine depletion, Behavioural Brain Research, 237, 2013. Crossref

  6. LaLumiere Ryan T., Kalivas Peter W., Motivational Systems: Rewards and Incentive Value, in Handbook of Psychology, Second Edition, 2012. Crossref

  7. Marinelli Michela, Dopaminergic Reward Pathways and Effects of Stress, in Stress and Addiction, 2007. Crossref

  8. Delgado Mauricio R, Li Jian, Schiller Daniela, Phelps Elizabeth A, The role of the striatum in aversive learning and aversive prediction errors, Philosophical Transactions of the Royal Society B: Biological Sciences, 363, 1511, 2008. Crossref

  9. Hurd Yasmin L., Hall Hkan, Chapter IX Human forebrain dopamine systems: Characterization of the normal brain and in relation to psychiatric disorders, in Dopamine, 21, 2005. Crossref

  10. Bellebaum Christian, Brodmann Katja, Thoma Patrizia, Active and observational reward learning in adults with autism spectrum disorder: relationship with empathy in an atypical sample, Cognitive Neuropsychiatry, 19, 3, 2014. Crossref

  11. Chang Chun-hui, Grace Anthony A., Some dopamine neurons may be more impulsive than others: Why differences in receptors and transporters can affect dopamine function in Parkinson's disease, Movement Disorders, 28, 10, 2013. Crossref

  12. Fran�ois C., Yelnik J., Tand� D., Agid Y., Hirsch E.C., Dopaminergic cell group A8 in the monkey: Anatomical organization and projections to the striatum, The Journal of Comparative Neurology, 414, 3, 1999. Crossref

  13. García-Amado María, Prensa Lucía, Distribution of dopamine transporter immunoreactive fibers in the human amygdaloid complex, European Journal of Neuroscience, 38, 11, 2013. Crossref

  14. Cromwell Howard C., King Bryan H., , 29, 2004. Crossref

  15. Jahanshahi Ali, Vlamings Rinske, Kaya Ahmet Hilmi, Lim Lee Wei, Janssen Marcus L.F., Tan Sonny, Visser-Vandewalle Veerle, Steinbusch Harry W.M., Temel Yasin, Hyperdopaminergic Status in Experimental Huntington Disease, Journal of Neuropathology & Experimental Neurology, 69, 9, 2010. Crossref

  16. Abi-Dargham Anissa, Evidence from brain imaging studies for dopaminergic alterations in schizophrenia, in Dopamine in the Pathophysiology and Treatment of Schizophrenia, 2003. Crossref

  17. Schweimer Judith, Saft Simone, Hauber Wolfgang, Involvement of catecholamine neurotransmission in the rat anterior cingulate in effort-related decision making., Behavioral Neuroscience, 119, 6, 2005. Crossref

  18. Fudge Julie L., Breitbart Michael A., McClain Crystal, Amygdaloid inputs define a caudal component of the ventral striatum in primates, The Journal of Comparative Neurology, 476, 4, 2004. Crossref

  19. Jahanshahi A., Vlamings R., van Roon-Mom W.M.C., Faull R.L.M., Waldvogel H.J., Janssen M.L.F., Yakkioui Y., Zeef D.H., Kocabicak E., Steinbusch H.W.M., Temel Y., Changes in brainstem serotonergic and dopaminergic cell populations in experimental and clinical Huntington’s disease, Neuroscience, 238, 2013. Crossref

  20. Finan Patrick H., Smith Michael T., The comorbidity of insomnia, chronic pain, and depression: Dopamine as a putative mechanism, Sleep Medicine Reviews, 17, 3, 2013. Crossref

  21. Daunais James B., Letchworth Sharon R., Sim-Selley Laura J., Smith Hilary R., Childers Steven R., Porrino Linda J., Functional and anatomical localization of mu opioid receptors in the striatum, amygdala, and extended amygdala of the nonhuman primate, The Journal of Comparative Neurology, 433, 4, 2001. Crossref

  22. Brody Arthur, Neuroimaging of Nicotine Dependence, in Medication Treatments for Nicotine Dependence, 2006. Crossref

  23. Platt Michael, Lau Brian, Glimcher Paul, Situating the Superior Colliculus within the Gaze Control Network, in The Superior Colliculus, 2003. Crossref

  24. Guillin Olivier, Abi‐Dargham Anissa, Laruelle Marc, Neurobiology of Dopamine in Schizophrenia, in Integrating the Neurobiology of Schizophrenia, 78, 2007. Crossref

  25. Szechtman Henry, Woody Erik, Obsessive-Compulsive Disorder as a Disturbance of Security Motivation., Psychological Review, 111, 1, 2004. Crossref

  26. Smith Yoland, Villalba Rosa, Striatal and extrastriatal dopamine in the basal ganglia: An overview of its anatomical organization in normal and Parkinsonian brains, Movement Disorders, 23, S3, 2008. Crossref

  27. Dopeso-Reyes Iria G., Rico Alberto J., Roda Elvira, Sierra Salvador, Pignataro Diego, Lanz Maria, Sucunza Diego, Chang-Azancot Luis, Lanciego Jose L., Calbindin content and differential vulnerability of midbrain efferent dopaminergic neurons in macaques, Frontiers in Neuroanatomy, 8, 2014. Crossref

  28. Marchand William R, Yurgelun-Todd Deborah, Striatal structure and function in mood disorders: a comprehensive review, Bipolar Disorders, 12, 8, 2010. Crossref

  29. Vlamings Rinske, Zeef Dagmar H., Janssen Marcus L. F., Oosterloo Mayke, Schaper Frederic, Jahanshahi Ali, Temel Yasin, Lessons Learned from the Transgenic Huntington's Disease Rats, Neural Plasticity, 2012, 2012. Crossref

  30. Fudge J.L, Haber S.N, The central nucleus of the amygdala projection to dopamine subpopulations in primates, Neuroscience, 97, 3, 2000. Crossref

  31. McFarland Krista, Motor Control: Pyramidal, Extrapyramidal, and Limbic Motor Control, in Handbook of Neuroscience for the Behavioral Sciences, 2009. Crossref

  32. Vo Andrew, Hiebert Nole M., Seergobin Ken N., Solcz Stephanie, Partridge Allison, MacDonald Penny A., Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease, Frontiers in Human Neuroscience, 8, 2014. Crossref

  33. Gruber Matthias J., Gelman Bernard D., Ranganath Charan, States of Curiosity Modulate Hippocampus-Dependent Learning via the Dopaminergic Circuit, Neuron, 84, 2, 2014. Crossref

  34. Bettcher Brianne Magouirk, Giovannetti Tania, From Cognitive Neuroscience to Geriatric Neuropsychology: What Do Current Conceptualizations of the Action Error Handling Process Mean for Older Adults?, Neuropsychology Review, 19, 1, 2009. Crossref

  35. Martorana Alessandro, Koch Giacomo, “Is dopamine involved in Alzheimer's disease?”, Frontiers in Aging Neuroscience, 6, 2014. Crossref

  36. Chandler Daniel J., Waterhouse Barry D., Gao Wen-Jun, New perspectives on catecholaminergic regulation of executive circuits: evidence for independent modulation of prefrontal functions by midbrain dopaminergic and noradrenergic neurons, Frontiers in Neural Circuits, 8, 2014. Crossref

  37. Kobza Stefan, Bellebaum Christian, Processing of action- but not stimulus-related prediction errors differs between active and observational feedback learning, Neuropsychologia, 66, 2015. Crossref

  38. May Paul J., McHaffie John G., Stanford Terrence R., Jiang Huai, Costello M. Gabriela, Coizet Veronique, Hayes Lauren M., Haber Suzanne N., Redgrave Peter, Tectonigral projections in the primate: a pathway for pre-attentive sensory input to midbrain dopaminergic neurons, European Journal of Neuroscience, 29, 3, 2009. Crossref

  39. Yetnikoff L., Lavezzi H.N., Reichard R.A., Zahm D.S., An update on the connections of the ventral mesencephalic dopaminergic complex, Neuroscience, 282, 2014. Crossref

  40. Sanchez-Catalan M.J., Kaufling J., Georges F., Veinante P., Barrot M., The antero-posterior heterogeneity of the ventral tegmental area, Neuroscience, 282, 2014. Crossref

  41. Waldvogel H.J., Baer K., Gai W.-P., Gilbert R.T., Rees M.I., Mohler H., Faull R.L.M., Differential localization of GABAA receptor subunits within the substantia nigra of the human brain: An immunohistochemical study, The Journal of Comparative Neurology, 506, 6, 2008. Crossref

  42. El-Amamy Heather, Holland Peter C., Dissociable effects of disconnecting amygdala central nucleus from the ventral tegmental area or substantia nigra on learned orienting and incentive motivation, European Journal of Neuroscience, 25, 5, 2007. Crossref

  43. Murty Vishnu P., Shermohammed Maheen, Smith David V., Carter R. McKell, Huettel Scott A., Adcock R. Alison, Resting state networks distinguish human ventral tegmental area from substantia nigra, NeuroImage, 100, 2014. Crossref

  44. Martinez Diana, Slifstein Mark, Narendran Rajesh, Foltin Richard W, Broft Allegra, Hwang Dah-Ren, Perez Audrey, Abi-Dargham Anissa, Fischman Marian W, Kleber Herbert D, Laruelle Marc, Dopamine D1 Receptors in Cocaine Dependence Measured with PET and the Choice to Self-Administer Cocaine, Neuropsychopharmacology, 34, 7, 2009. Crossref

  45. Marchand William R., Cortico-basal ganglia circuitry: a review of key research and implications for functional connectivity studies of mood and anxiety disorders, Brain Structure and Function, 215, 2, 2010. Crossref

  46. WEST ANTHONY R., FLORESCO STAN B., CHARARA ALI, ROSENKRANZ J. AMIEL, GRACE ANTHONY A., Electrophysiological Interactions between Striatal Glutamatergic and Dopaminergic Systems, Annals of the New York Academy of Sciences, 1003, 1, 2003. Crossref

  47. Lim Sung-Joo, Fiez Julie A., Holt Lori L., How may the basal ganglia contribute to auditory categorization and speech perception?, Frontiers in Neuroscience, 8, 2014. Crossref

  48. Sannino Sara, Gozzi Alessandro, Cerasa Antonio, Piras Fabrizio, Scheggia Diego, Managò Francesca, Damiano Mario, Galbusera Alberto, Erickson Lucy C., De Pietri Tonelli Davide, Bifone Angelo, Tsaftaris Sotirios A., Caltagirone Carlo, Weinberger Daniel R., Spalletta Gianfranco, Papaleo Francesco, COMT Genetic Reduction Produces Sexually Divergent Effects on Cortical Anatomy and Working Memory in Mice and Humans, Cerebral Cortex, 25, 9, 2015. Crossref

  49. Adcock R. Alison, Thangavel Arul, Whitfield-Gabrieli Susan, Knutson Brian, Gabrieli John D.E., Reward-Motivated Learning: Mesolimbic Activation Precedes Memory Formation, Neuron, 50, 3, 2006. Crossref

  50. Bellebaum Christian, Colosio Marco, From Feedback- to Response-based Performance Monitoring in Active and Observational Learning, Journal of Cognitive Neuroscience, 26, 9, 2014. Crossref

  51. Hiebert Nole M., Vo Andrew, Hampshire Adam, Owen Adrian M., Seergobin Ken N., MacDonald Penny A., Striatum in stimulus–response learning via feedback and in decision making, NeuroImage, 101, 2014. Crossref

  52. Rice Matthew W., Roberts Rosalinda C., Melendez-Ferro Miguel, Perez-Costas Emma, Mapping dopaminergic deficiencies in the substantia nigra/ventral tegmental area in schizophrenia, Brain Structure and Function, 221, 1, 2016. Crossref

  53. Schneier Franklin R., Abi-Dargham Anissa, Martinez Diana, Slifstein Mark, Hwang Dah-Ren, Liebowitz Michael R., Laruelle Marc, Dopamine transporters, D2receptors, and dopamine release in generalized social anxiety disorder, Depression and Anxiety, 26, 5, 2009. Crossref

  54. McFarland Krista, Kalivas Peter W., Motivational Systems, in Handbook of Psychology, 2003. Crossref

  55. Alderson Helen L., Latimer Mary P., Winn Philip, Intravenous self-administration of nicotine is altered by lesions of the posterior, but not anterior, pedunculopontine tegmental nucleus, European Journal of Neuroscience, 23, 8, 2006. Crossref

  56. Cromwell H.C., Klein A., Mears R.P., Single unit and population responses during inhibitory gating of striatal activity in freely moving rats, Neuroscience, 146, 1, 2007. Crossref

  57. Tomasi Dardo, Volkow Nora D., Abnormal Functional Connectivity in Children with Attention-Deficit/Hyperactivity Disorder, Biological Psychiatry, 71, 5, 2012. Crossref

  58. Gonzales Kalynda K., Smith Yoland, Cholinergic interneurons in the dorsal and ventral striatum: anatomical and functional considerations in normal and diseased conditions, Annals of the New York Academy of Sciences, 1349, 1, 2015. Crossref

  59. Matsukawa Kanji, Ishii Kei, Ishida Tomoko, Nagai Atsushi, Liang Nan, Stimulation of the mesencephalic ventral tegmental area blunts the sensitivity of cardiac baroreflex in decerebrate cats, Autonomic Neuroscience, 189, 2015. Crossref

  60. Bellebaum C., Jokisch D., Gizewski E.R., Forsting M., Daum I., The neural coding of expected and unexpected monetary performance outcomes: Dissociations between active and observational learning, Behavioural Brain Research, 227, 1, 2012. Crossref

  61. Pickel V.M., Colago E.E., Mania I., Molosh A.I., Rainnie D.G., Dopamine D1 receptors co-distribute with N-methyl-d-aspartic acid type-1 subunits and modulate synaptically-evoked N-methyl-d-aspartic acid currents in rat basolateral amygdala, Neuroscience, 142, 3, 2006. Crossref

  62. Gomes Margarete Zanardo, Raisman-Vozari Rita, Del Bel Elaine A., A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway, Brain Research, 1203, 2008. Crossref

  63. Lee Byeong-Taek, Lee Hwa-Young, Han Changsu, Pae Chi-Un, Tae Woo Suk, Lee Min-Soo, Joe Sook-Haeng, Jung In-Kwa, Ham Byung-Joo, DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli, Behavioural Brain Research, 223, 1, 2011. Crossref

  64. Ljungstrom Trine, Grunnet Morten, Jensen Bo Skaaning, Olesen Søren-Peter, Functional coupling between heterologously expressed dopamine D2 receptors and KCNQ channels, Pflügers Archiv - European Journal of Physiology, 446, 6, 2003. Crossref

  65. Alcaro Antonio, Huber Robert, Panksepp Jaak, Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective, Brain Research Reviews, 56, 2, 2007. Crossref

  66. Mitchell Anna S., The mediodorsal thalamus as a higher order thalamic relay nucleus important for learning and decision-making, Neuroscience & Biobehavioral Reviews, 54, 2015. Crossref

  67. Tricomi Elizabeth, Fiez Julie A., Feedback signals in the caudate reflect goal achievement on a declarative memory task, NeuroImage, 41, 3, 2008. Crossref

  68. Thoma Patrizia, Norra Christine, Juckel Georg, Suchan Boris, Bellebaum Christian, Performance monitoring and empathy during active and observational learning in patients with major depression, Biological Psychology, 109, 2015. Crossref

  69. Leon Matthew I., Shadlen Michael N., Effect of Expected Reward Magnitude on the Response of Neurons in the Dorsolateral Prefrontal Cortex of the Macaque, Neuron, 24, 2, 1999. Crossref

  70. Poldrack Russell A., Rodriguez Paul, How do memory systems interact? Evidence from human classification learning, Neurobiology of Learning and Memory, 82, 3, 2004. Crossref

  71. Melchitzky D.S., Erickson S.L., Lewis D.A., Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals, Neuroscience, 143, 4, 2006. Crossref

  72. Pioli E.Y., Meissner W., Sohr R., Gross C.E., Bezard E., Bioulac B.H., Differential behavioral effects of partial bilateral lesions of ventral tegmental area or substantia nigra pars compacta in rats, Neuroscience, 153, 4, 2008. Crossref

  73. Murnane Kevin S., Howell Leonard L., Neuroimaging and drug taking in primates, Psychopharmacology, 216, 2, 2011. Crossref

  74. Ghilardi M. Felice, Feigin Andrew S., Battaglia Fortunato, Silvestri Giulia, Mattis Paul, Eidelberg David, Di Rocco Alessandro, L-Dopa infusion does not improve explicit sequence learning in Parkinson's disease, Parkinsonism & Related Disorders, 13, 3, 2007. Crossref

  75. Zald D.H., Substantia Nigra, in Brain Mapping, 2015. Crossref

  76. Pan Xiaochuan, Sakagami Masamichi, Category representation and generalization in the prefrontal cortex, European Journal of Neuroscience, 35, 7, 2012. Crossref

  77. Porrino Linda J, Daunais James B, Smith Hilary R, Nader Michael A, The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administration, Neuroscience & Biobehavioral Reviews, 27, 8, 2004. Crossref

  78. Moore Holly, West Anthony R, Grace Anthony A, The regulation of forebrain dopamine transmission: relevance to the pathophysiology and psychopathology of schizophrenia, Biological Psychiatry, 46, 1, 1999. Crossref

  79. Pioli Elsa, Sohr Reinhard, Meissner Wassilios, Barthe Nicole, Gross Christian E., Bezard Erwan, Bioulac Bernard H., Partial bilateral mesencephalic lesions affect D1 but not D2 binding in both the striatum and cortex, Neurochemistry International, 45, 7, 2004. Crossref

  80. Smith Yoland, Kieval Jeremy Z., Anatomy of the dopamine system in the basal ganglia, Trends in Neurosciences, 23, 2000. Crossref

  81. Becerra Lino, Breiter Hans C., Wise Roy, Gonzalez R.Gilberto, Borsook David, Reward Circuitry Activation by Noxious Thermal Stimuli, Neuron, 32, 5, 2001. Crossref

  82. Tricomi Elizabeth M, Delgado Mauricio R, Fiez Julie A, Modulation of Caudate Activity by Action Contingency, Neuron, 41, 2, 2004. Crossref

  83. Knutson Brian, Cooper Jeffrey C., The Lure of the Unknown, Neuron, 51, 3, 2006. Crossref

  84. Woody Erik Z., Szechtman Henry, Adaptation to potential threat: The evolution, neurobiology, and psychopathology of the security motivation system, Neuroscience & Biobehavioral Reviews, 35, 4, 2011. Crossref

  85. Ikemoto Satoshi, Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex, Brain Research Reviews, 56, 1, 2007. Crossref

  86. Matsukawa Kanji, Nakamoto Tomoko, Liang Nan, Electrical stimulation of the mesencephalic ventral tegmental area evokes skeletal muscle vasodilatation in the cat and rat, The Journal of Physiological Sciences, 61, 4, 2011. Crossref

  87. Vo Andrew, Seergobin Ken N., MacDonald Penny A., Effects of levodopa on stimulus-response learning versus response selection in healthy young adults, Behavioural Brain Research, 317, 2017. Crossref

  88. Jerzemowska Grażyna, Hypothalamic and Midbrain Cells, Tyrosine Hydroxylase, and Implications for Drug Addiction, in Neuropathology of Drug Addictions and Substance Misuse, 2016. Crossref

  89. Semprini Roberta, Lubrano Adele, Misaggi Giulia, Martorana Alessandro, Apathy as Marker of Frail Status, Journal of Aging Research, 2012, 2012. Crossref

  90. Stievenard Alicia, Méquinion Mathieu, Andrews Zane B., Destée Alain, Chartier-Harlin Marie-Christine, Viltart Odile, Vanbesien-Mailliot Christel C., Is there a role for ghrelin in central dopaminergic systems? Focus on nigrostriatal and mesocorticolimbic pathways, Neuroscience & Biobehavioral Reviews, 73, 2017. Crossref

  91. Schoonover Kirsten E, McCollum Lesley A, Roberts Rosalinda C, Protein Markers of Neurotransmitter Synthesis and Release in Postmortem Schizophrenia Substantia Nigra, Neuropsychopharmacology, 42, 2, 2017. Crossref

  92. Gallant Haley, Vo Andrew, Seergobin Ken N., MacDonald Penny A., Pramipexole Impairs Stimulus-Response Learning in Healthy Young Adults, Frontiers in Neuroscience, 10, 2016. Crossref

  93. Costa Vincent D., Dal Monte Olga, Lucas Daniel R., Murray Elisabeth A., Averbeck Bruno B., Amygdala and Ventral Striatum Make Distinct Contributions to Reinforcement Learning, Neuron, 92, 2, 2016. Crossref

  94. Vo Andrew, Seergobin Ken N., Morrow Sarah A., MacDonald Penny A., Levodopa impairs probabilistic reversal learning in healthy young adults, Psychopharmacology, 233, 14, 2016. Crossref

  95. Marusak Hilary A., Hatfield Joshua R.B., Thomason Moriah E., Rabinak Christine A., Reduced Ventral Tegmental Area–Hippocampal Connectivity in Children and Adolescents Exposed to Early Threat, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2, 2, 2017. Crossref

  96. Roy Arpan, Bhattacharyya Malay, Identifying microRNAs related to Alzheimer's disease from differential methylation signatures, Gene Reports, 4, 2016. Crossref

  97. Yang Xue Qing, Glizer Daniel, Vo Andrew, Seergobin Ken N., MacDonald Penny A., Pramipexole Increases Go Timeouts but Not No-go Errors in Healthy Volunteers, Frontiers in Human Neuroscience, 10, 2016. Crossref

  98. Weismüller Benjamin, Bellebaum Christian, Expectancy affects the feedback-related negativity (FRN) for delayed feedback in probabilistic learning, Psychophysiology, 53, 11, 2016. Crossref

  99. De Deurwaerdère Philippe, Di Giovanni Giuseppe, Serotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications, Progress in Neurobiology, 151, 2017. Crossref

  100. Zirnheld Patrick J., Carroll Christine A., Kieffaber Paul D., O'Donnell Brian F., Shekhar Anantha, Hetrick William P., Haloperidol Impairs Learning and Error-related Negativity in Humans, Journal of Cognitive Neuroscience, 16, 6, 2004. Crossref

  101. Katsuki Fumi, Constantinidis Christos, Zochowski Michal, Time Course of Functional Connectivity in Primate Dorsolateral Prefrontal and Posterior Parietal Cortex during Working Memory, PLoS ONE, 8, 11, 2013. Crossref

  102. Fudge Julie L, Kelly Emily A, Pal Ria, Bedont Joseph L, Park Lydia, Ho Brian, Beyond the Classic VTA: Extended Amygdala Projections to DA-Striatal Paths in the Primate, Neuropsychopharmacology, 42, 8, 2017. Crossref

  103. West Anthony R., Grace Anthony A., Striatal Nitric Oxide Signaling Regulates the Neuronal Activity of Midbrain Dopamine Neurons In Vivo, Journal of Neurophysiology, 83, 4, 2000. Crossref

  104. Zhou Xin, Katsuki Fumi, Qi Xue-Lian, Constantinidis Christos, Neurons with inverted tuning during the delay periods of working memory tasks in the dorsal prefrontal and posterior parietal cortex, Journal of Neurophysiology, 108, 1, 2012. Crossref

  105. Abi-Dargham Anissa, Moore Holly, Prefrontal DA Transmission at D1 Receptors and the Pathology of Schizophrenia, The Neuroscientist, 9, 5, 2003. Crossref

  106. Holroyd Clay B, Praamstra Peter, Plat Erik, Coles Michael G.H, Spared error-related potentials in mild to moderate Parkinson’s disease, Neuropsychologia, 40, 12, 2002. Crossref

  107. Nakamoto Tomoko, Matsukawa Kanji, Liang Nan, Wakasugi Rie, Wilson L. Britt, Horiuchi Jouji, Coactivation of renal sympathetic neurons and somatic motor neurons by chemical stimulation of the midbrain ventral tegmental area, Journal of Applied Physiology, 110, 5, 2011. Crossref

  108. Peterson Andrew C., Zhang Sheng, Hu Sien, Chao Herta H., Li Chiang-shan R., The Effects of Age, from Young to Middle Adulthood, and Gender on Resting State Functional Connectivity of the Dopaminergic Midbrain, Frontiers in Human Neuroscience, 11, 2017. Crossref

  109. Martino Matteo, Magioncalda Paola, Yu Hua, Li Xiaojing, Wang Qiang, Meng Yajing, Deng Wei, Li Yinfei, Li Mingli, Ma Xiaohong, Lane Timothy, Duncan Niall W, Northoff Georg, Li Tao, Abnormal Resting-State Connectivity in a Substantia Nigra-Related Striato-Thalamo-Cortical Network in a Large Sample of First-Episode Drug-Naïve Patients With Schizophrenia, Schizophrenia Bulletin, 44, 2, 2018. Crossref

  110. Rice Matthew W., Smith Kristen L., Roberts Rosalinda C., Perez-Costas Emma, Melendez-Ferro Miguel, Aumann Tim Douglas, Assessment of Cytochrome C Oxidase Dysfunction in the Substantia Nigra/Ventral Tegmental Area in Schizophrenia, PLoS ONE, 9, 6, 2014. Crossref

  111. Tewari Ambika, Fremont Rachel, Khodakhah Kamran, It's not just the basal ganglia: Cerebellum as a target for dystonia therapeutics, Movement Disorders, 32, 11, 2017. Crossref

  112. Martinez Diana, Broft Allegra, Foltin Richard W, Slifstein Mark, Hwang Dah-Ren, Huang Yiyun, Perez Audrey, Frankel W Gordon, Cooper Thomas, Kleber Herbert D, Fischman Marian W, Laruelle Marc, Cocaine Dependence and D2 Receptor Availability in the Functional Subdivisions of the Striatum: Relationship with Cocaine-Seeking Behavior, Neuropsychopharmacology, 29, 6, 2004. Crossref

  113. Kliem Michele A., Maidment Nigel T., Ackerson Larry C., Chen Sugong, Smith Yoland, Wichmann Thomas, Activation of Nigral and Pallidal Dopamine D1-Like Receptors Modulates Basal Ganglia Outflow in Monkeys, Journal of Neurophysiology, 98, 3, 2007. Crossref

  114. Vo Andrew, Seergobin Ken N., MacDonald Penny A., Independent effects of age and levodopa on reversal learning in healthy volunteers, Neurobiology of Aging, 69, 2018. Crossref

  115. Yang Xue Q., Lauzon Brian, Seergobin Ken N., MacDonald Penny A., Dopaminergic Therapy Increases Go Timeouts in the Go/No-Go Task in Patients with Parkinson’s Disease, Frontiers in Human Neuroscience, 11, 2018. Crossref

  116. Horne Alexandra J., Chiew Kimberly S., Zhuang Jie, George Linda K., Adcock R. Alison, Potter Guy G., Lad Eleonora M., Cousins Scott W., Lin Frank R., Mamo Sara K., Chen Nan-Kuei, Maciejewski Abigail J., Duong Fernandez Xuan, Whitson Heather E., Relating Sensory, Cognitive, and Neural Factors to Older Persons’ Perceptions about Happiness: An Exploratory Study, Journal of Aging Research, 2018, 2018. Crossref

  117. Weele Caitlin M. Vander, Siciliano Cody A., Tye Kay M., Dopamine tunes prefrontal outputs to orchestrate aversive processing, Brain Research, 1713, 2019. Crossref

  118. Weismüller Benjamin, Ghio Marta, Logmin Kazimierz, Hartmann Christian, Schnitzler Alfons, Pollok Bettina, Südmeyer Martin, Bellebaum Christian, Effects of feedback delay on learning from positive and negative feedback in patients with Parkinson's disease off medication, Neuropsychologia, 117, 2018. Crossref

  119. ten Donkelaar Hans J., van de Warrenburg Bart, Willemsen Michèl, Küsters Benno, Hashizume Yoshio, Hori Akira, Basal Ganglia, in Clinical Neuroanatomy, 2011. Crossref

  120. Miller Michael L., Chadwick Benjamin, Morris Claudia V., Michaelides Michael, Hurd Yasmin L., Cannabinoid-Opioid Interactions, in Cannabinoid Modulation of Emotion, Memory, and Motivation, 2015. Crossref

  121. Fudge Julie L., Song David D., Haber Suzanne N., A Partial Dopamine Lesion Impairs Performance on a Procedural Learning Task: Implications for Parkinson’s Disease, in The Basal Ganglia VI, 54, 2002. Crossref

  122. Basal ganglia, in The Brain and Behavior, 2005. Crossref

  123. Sharma Anil, Brody Arthur L., In vivo Brain Imaging of Human Exposure to Nicotine and Tobacco, in Nicotine Psychopharmacology, 192, 2009. Crossref

  124. Trutti Anne C., Mulder Martijn J., Hommel Bernhard, Forstmann Birte U., Functional neuroanatomical review of the ventral tegmental area, NeuroImage, 191, 2019. Crossref

  125. Weismüller Benjamin, Kullmann Janna, Hoenen Matthias, Bellebaum Christian, Effects of feedback delay and agency on feedback‐locked beta and theta power during reinforcement learning, Psychophysiology, 56, 10, 2019. Crossref

  126. Haber Suzanne N., Deniau Jean-Michel, Groenewegen Henk J., O’Donnell Patricio, McGinty Jacqueline F., Baunez Christelle, The Ventral/Dorsal Divide: To Integrate or Separate, in The Basal Ganglia VIII, 56, 2005. Crossref

  127. Arnsten Amy F. T., Wang Min, Paspalas Constantinos D., Witkin Jeffrey M., Dopamine’s Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders, Pharmacological Reviews, 67, 3, 2015. Crossref

  128. Abi-Dargham A., Cortical Dopamine in Schizophrenia, in Handbook of Neurochemistry and Molecular Neurobiology, 2009. Crossref

  129. Hosp Jonas A., Coenen V. A., Rijntjes M., Egger K., Urbach H., Weiller C., Reisert M., Ventral tegmental area connections to motor and sensory cortical fields in humans, Brain Structure and Function, 224, 8, 2019. Crossref

  130. Aboitiz F., Dynamics of a Neuromodulator – I. The Role of Dopaminergic Signaling in Goal-Directed Behavior, in From Attention to Goal-Directed Behavior, 2009. Crossref

  131. Haber S. N., The Place of Dopamine Neurons Within the Organization of the Forebrain, in Dopamine in the CNS I, 154 / 1, 2002. Crossref

  132. Mendoza John E., Foundas Anne L., Neurochemical Transmission, in Clinical Neuroanatomy: A Neurobehavioral Approach, 2008. Crossref

  133. Martino Matteo, Magioncalda Paola, Conio Benedetta, Capobianco Laura, Russo Daniel, Adavastro Giulia, Tumati Shankar, Tan Zhonglin, Lee Hsin-Chien, Lane Timothy J, Amore Mario, Inglese Matilde, Northoff Georg, Abnormal Functional Relationship of Sensorimotor Network With Neurotransmitter-Related Nuclei via Subcortical-Cortical Loops in Manic and Depressive Phases of Bipolar Disorder, Schizophrenia Bulletin, 46, 1, 2020. Crossref

  134. Prensa L, Giménez-Amaya J M, Parent A, Bernácer J, Cebrián C, The Nigrostriatal Pathway: Axonal Collateralization and Compartmental Specificity, in Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra, 2009. Crossref

  135. Yu Siyi, Ortiz Ana, Gollub Randy L., Wilson Georgia, Gerber Jessica, Park Joel, Huang Yiting, Shen Wei, Chan Suk-Tak, Wasan Ajay D., Edwards Robert R., Napadow Vitaly, Kaptchuk Ted J., Rosen Bruce, Kong Jian, Acupuncture Treatment Modulates the Connectivity of Key Regions of the Descending Pain Modulation and Reward Systems in Patients with Chronic Low Back Pain, Journal of Clinical Medicine, 9, 6, 2020. Crossref

  136. Richter Anja, Reinhard Fabian, Kraemer Bernd, Gruber Oliver, A high-resolution fMRI approach to characterize functionally distinct neural pathways within dopaminergic midbrain and nucleus accumbens during reward and salience processing, European Neuropsychopharmacology, 36, 2020. Crossref

  137. Huntley Edward D., Marusak Hilary A., Berman Sarah E., Zundel Clara G., Hatfield Joshua R.B., Keating Daniel P., Rabinak Christine A., Adolescent substance use and functional connectivity between the ventral striatum and hippocampus, Behavioural Brain Research, 390, 2020. Crossref

  138. Turchi Janita, Buffalari Deanne, Mishkin Mortimer, Double dissociation of pharmacologically induced deficits in visual recognition and visual discrimination learning, Learning & Memory, 15, 8, 2008. Crossref

  139. Deng Qiaolin, Andersson Elisabet, Hedlund Eva, Alekseenko Zhanna, Coppola Eva, Panman Lia, Millonig James H., Brunet Jean-Francois, Ericson Johan, Perlmann Thomas, Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development, Development, 138, 16, 2011. Crossref

  140. Ferris Mark J., Calipari Erin S., Yorgason Jordan T., Jones Sara R., Examining the Complex Regulation and Drug-Induced Plasticity of Dopamine Release and Uptake Using Voltammetry in Brain Slices, ACS Chemical Neuroscience, 4, 5, 2013. Crossref

  141. De Deurwaerdère Philippe, Chagraoui Abdeslam, Di Giovanni Giuseppe, Serotonin/dopamine interaction: Electrophysiological and neurochemical evidence, in 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance - Part B, 261, 2021. Crossref

  142. Taylor Stephan F, Luan Phan K, Britton Jennifer C, Liberzon Israel, Neural Response to Emotional Salience in Schizophrenia, Neuropsychopharmacology, 30, 5, 2005. Crossref

  143. Lidstone Sarah C. Christine, Stoessl A. Jon, Understanding the Placebo Effect: Contributions from Neuroimaging, Molecular Imaging and Biology, 9, 4, 2007. Crossref

  144. Basal ganglia, in The Brain and Behavior, 2010. Crossref

  145. Gurevich Eugenia V., , 2022. Crossref

  146. Eulitz Dirk, Prüss Harald, Derst Christian, Veh Rüdiger W., Heterogeneous Distribution of Kir3 Potassium Channel Proteins Within Dopaminergic Neurons in the Mesencephalon of the Rat Brain, Cellular and Molecular Neurobiology, 27, 3, 2007. Crossref

  147. Nikoshkov Andrej, Drakenberg Katarina, Wang Xinyu, Horvath Monika Cs., Keller Eva, Hurd Yasmin L., Opioid neuropeptide genotypes in relation to heroin abuse: Dopamine tone contributes to reversed mesolimbic proenkephalin expression, Proceedings of the National Academy of Sciences, 105, 2, 2008. Crossref

  148. ten Donkelaar Hans J., van de Warrenburg Bart, Willemsen Michèl, Küsters Benno, Hashizume Yoshio, Hori Akira, Basal Ganglia, in Clinical Neuroanatomy, 2020. Crossref

  149. Cai Jing, Tong Qingchun, Anatomy and Function of Ventral Tegmental Area Glutamate Neurons, Frontiers in Neural Circuits, 16, 2022. Crossref

  150. Borráz-León Javier I., Rantala Markus J., Krams Indrikis A., Cerda-Molina Ana Lilia, Contreras-Garduño Jorge, Are Toxoplasma-infected subjects more attractive, symmetrical, or healthier than non-infected ones? Evidence from subjective and objective measurements, PeerJ, 10, 2022. Crossref

  151. Golubev Aleksei G., Carving the senescent phenotype by the chemical reactivity of catecholamines: An integrative review, Ageing Research Reviews, 75, 2022. Crossref

  152. Kelly Emily A., Contreras Jancy, Duan Annie, Vassell Rochelle, Fudge Julie L., Unbiased Stereological Estimates of Dopaminergic and GABAergic Neurons in the A10, A9, and A8 Subregions in the Young Male Macaque, Neuroscience, 496, 2022. Crossref

  153. Schulz Julia, Zimmermann Juliana, Sorg Christian, Menegaux Aurore, Brandl Felix, Magnetic resonance imaging of the dopamine system in schizophrenia – A scoping review, Frontiers in Psychiatry, 13, 2022. Crossref

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