Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1813, Issue 9, September 2011, Pages 1593-1606
Review
Nuclear import by karyopherin-βs: Recognition and inhibition☆
Under an Elsevier user license
open archive
Research Highlights
►Karyopherin-β (Kapβ) proteins transports protein cargos into the nucleus. ►Kapβs recognize nuclear localization signals or NLSs in their cargos. ►Of the 19 human Kapβs only two have well characterized NLSs. ►Many NLSs recognized by individual Kapβs are large and diverse in sequence. ►New approaches are needed to classify diverse NLSs recognized by most Kapβs.
Keywords
Karyopherin
Importin
Transportin
Nuclear localization signal
Classical-NLS
PY-NLS
Nuclear pore complex
Nuclear localization
Nuclear import
NLS
Cited by (0)
- ☆
-
This article is part of a Special Issue entitled: Regulation of Signaling and Cellular Fate through Modulation of Nuclear Protein Import.
Copyright © 2010 Elsevier B.V. All rights reserved.