Indiana University School of Medicine, Department of Pathology and Laboratory Medicine, 635 Barnhill Drive, MS A128, Indianapolis, IN 46202Search for more papers by this author

Oye Gureje MBBS, PhD, DSc,

Oye Gureje MBBS, PhD, DSc

Departments of Psychiatry, University of Ibadan, College of Medicine, Ibadan, Nigeria

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Adesola Ogunniyi MB, ChB,

Adesola Ogunniyi MB, ChB

Medicine, University of Ibadan, College of Medicine, Ibadan, Nigeria

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Olusegun Baiyewu MBBS,

Olusegun Baiyewu MBBS

Departments of Psychiatry, University of Ibadan, College of Medicine, Ibadan, Nigeria

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Brandon Price MS,

Brandon Price MS

Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN

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Frederick W. Unverzagt PhD,

Frederick W. Unverzagt PhD

Psychiatry, Indiana University School of Medicine, Indianapolis, IN

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Rebecca M. Evans MD,

Rebecca M. Evans MD

Neurology, Indiana University School of Medicine, Indianapolis, IN

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Valerie Smith-Gamble MD,

Valerie Smith-Gamble MD

Psychiatry, Indiana University School of Medicine, Indianapolis, IN

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Kathleen A. Lane MS,

Kathleen A. Lane MS

Medicine, Indiana University School of Medicine, Indianapolis, IN

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Sujuan Gao PhD,

Sujuan Gao PhD

Medicine, Indiana University School of Medicine, Indianapolis, IN

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Kathleen S. Hall PhD,

Kathleen S. Hall PhD

Psychiatry, Indiana University School of Medicine, Indianapolis, IN

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Hugh C. Hendrie MB, ChB,

Hugh C. Hendrie MB, ChB

Psychiatry, Indiana University School of Medicine, Indianapolis, IN

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Jill R. Murrell PhD,

Corresponding Author

Jill R. Murrell PhD

[email protected]

Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN

Indiana University School of Medicine, Department of Pathology and Laboratory Medicine, 635 Barnhill Drive, MS A128, Indianapolis, IN 46202Search for more papers by this author

First published: 22 December 2005

https://doi.org/10.1002/ana.20694

Citations: 91

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Abstract

Since 1992, research teams from Indiana University and the University of Ibadan have been collecting and comparing data from two diverse, elderly populations to identify risk factors for dementia and Alzheimer's disease. Apolipoprotein E (APOE) was genotyped in 2,245 Nigerian samples. Of these, 830 had a diagnosis: 459 were normal, and 140 had dementia including 123 diagnosed with Alzheimer's disease. In contrast with other populations, the APOE ε4 allele was not significantly associated with Alzheimer's disease or dementia. This lack of association in the Yoruba might reflect genetic variation, environmental factors, as well as genetic/environmental interactions. Ann neurol 2006

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Volume59, Issue1

January 2006

Pages 182-185

APOE ε4 is not associated with Alzheimer's disease in elderly Nigerians

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APOE ε4 is not associated with Alzheimer's disease in elderly Nigerians

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