ACS Publications. Most Trusted. Most Cited. Most Read
My Activity
CONTENT TYPES

Figure 1Loading Img

Comparison of Yield, Composition, and Antioxidant Activity of Turmeric (Curcuma longa L.) Extracts Obtained Using Various Techniques

View Author Information
LASEFI, DEA/FEA (College of Food Engineering), UNICAMP (State University of Campinas), Caixa Postal 6121, 13083-970, Campinas, SP, Brazil, and CPQBA, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas, Estrada PLN 393, 999 Vila Betel, Caixa Postal 6171, 13081-970 Paulínia, São Paulo, Brazil
Cite this: J. Agric. Food Chem. 2003, 51, 22, 6604–6611
Publication Date (Web):September 13, 2003
https://doi.org/10.1021/jf0345550
Copyright © 2003 American Chemical Society

    Article Views

    3965

    Altmetric

    -

    Citations

    160
    LEARN ABOUT THESE METRICS
    Other access options

    Abstract

    Turmeric extracts were obtained from two lots of raw material (M and S) using various techniques:  hydrodistillation, low pressure solvent extraction, Soxhlet, and supercritical extraction using carbon dioxide and cosolvents. The solvents and cosolvents tested were ethanol, isopropyl alcohol, and their mixture in equal proportions. The composition of the extracts was determined by gas chromatography−flame ionization detection (GC-FID) and UV. The largest yield (27%, weight) was obtained in the Soxhlet extraction (turmeric (S), ethanol = 1:100); the lowest yield was detected in the hydrodistillation process (2.1%). For the supercritical extraction, the best cosolvent was a mixture of ethanol and isopropyl alcohol. Sixty percent of the light fraction of the extracts consisted of ar-turmerone, (Z)-γ-atlantone, and (E)-γ-atlantone, except for the Soxhlet extracts (1:100, ethanol), for which only ar-turmeronol and (Z)-α-atlantone were detected. The maximum amount of curcuminoids (8.43%) was obtained using Soxhlet extraction (ethanol/isopropyl alcohol). The Soxhlet and low pressure extract exhibited the strongest antioxidant activities.

    Keywords: Curcuma longa L.; antioxidant and anticancer activities; cosolvents; hydrodistillation; solvent extraction; supercritical extraction; turmeric

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

     UNICAMP (State University of Campinas).

     CPQBA, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas.

    *

     To whom correspondence should be addressed. Tel:  55 19 3788-4033. Fax:  55 19 3788-4027. E-mail:  [email protected].

    Cited By

    This article is cited by 160 publications.

    1. Danilo Del Prete, Estrella Millán, Federica Pollastro, Giuseppina Chianese, Paolo Luciano, Juan A. Collado, Eduardo Munoz, Giovanni Appendino, and Orazio Taglialatela-Scafati . Turmeric Sesquiterpenoids: Expeditious Resolution, Comparative Bioactivity, and a New Bicyclic Turmeronoid. Journal of Natural Products 2016, 79 (2) , 267-273. https://doi.org/10.1021/acs.jnatprod.5b00637
    2. Yi-Chiang Hsu, Hsiao-Ching Weng, ShiuRu Lin and Yie W. Chien . Curcuminoids—Cellular Uptake by Human Primary Colon Cancer Cells As Quantitated by a Sensitive Hplc Assay and Its Relation with the Inhibition of Proliferation and Apoptosis. Journal of Agricultural and Food Chemistry 2007, 55 (20) , 8213-8222. https://doi.org/10.1021/jf070684v
    3. Mubashir Maqbool, Kakul Chaudhary, Rishabh Chalotra, Samrat Chauhan, Randhir Singh Dahiya. Phyto-pharmacology of Most Common Indian Culinary Spices and their Potential in Developing New Pharmaceutical Therapies. Current Traditional Medicine 2024, 10 (2) https://doi.org/10.2174/2215083810666230330161740
    4. Reza Davarnejad, Paul Charpentier, Sohrab Rohani, Vahid Jamshidi. Allantoin solubility in high pressure CO2: Statistical correlation and thermodynamic modeling. Journal of Molecular Liquids 2024, 399 , 124432. https://doi.org/10.1016/j.molliq.2024.124432
    5. Adriana Cruz, Eva Sánchez-Hernández, Ana Teixeira, Pablo Martín-Ramos, Ana Cunha, Rui Oliveira. Antifungal and Antioomycete Activities of a Curcuma longa L. Hydroethanolic Extract Rich in Bisabolene Sesquiterpenoids. Horticulturae 2024, 10 (2) , 124. https://doi.org/10.3390/horticulturae10020124
    6. Chikanshi Sharma, Purnamsree Gogoi, Madhu Kamle, Pradeep Kumar. Nanocurcumin: Herbal trends to develop novel antifungal agents. 2024, 315-328. https://doi.org/10.1016/B978-0-323-95305-4.00015-7
    7. Jagoda Kępińska-Pacelik, Wioletta Biel. Turmeric and Curcumin—Health-Promoting Properties in Humans versus Dogs. International Journal of Molecular Sciences 2023, 24 (19) , 14561. https://doi.org/10.3390/ijms241914561
    8. Farooq Hassan, Asmat Ullah Khan, Syed Zahoor ul Hassan Zaidi, Madiha Khan Niazi, Muhammad Amjed ismail. In Vitro Antioxidant and Inhibitory Study of Picrorhiza kurroa (Kutki), Syzygium aromaticum (Loung), Lawsonia inermis (Henna), Rheum emodi (Revand Chini), Curcuma longa (Haldi) Against Lipid Per-Oxidation in Mice Brain and Liver. Dose-Response 2023, 21 (4) https://doi.org/10.1177/15593258231210431
    9. Onoja O.J., Olawuni J.I.. DPPH Radical Scavenging Activity of Corydine Isolated from Tinospora cordifolia. African Journal of Pharmaceutical Sciences 2023, 3 (2) , 68-78. https://doi.org/10.51483/AFJPS.3.2.2023.68-78
    10. Veridiana Vera de Rosso1, Adriana Zerlotti Mercadante2. Dyes in South America. 2023, 63-73. https://doi.org/10.1002/9781119811749.ch5
    11. Hideki Kanda, Li Zhu, Wanying Zhu, Tao Wang. Ethanol-free extraction of curcumin and antioxidant activity of components from wet Curcuma longa L. by liquefied dimethyl ether. Arabian Journal of Chemistry 2023, 16 (4) , 104585. https://doi.org/10.1016/j.arabjc.2023.104585
    12. Saputera Saputera, Yetri Ludang, Herry Palangka Jaya, Titin Apung Atikah. Analysis of Bioactive Content of White Turmeric Rhizome (Kaempferia rotunda) Growing In Central Kalimantan. International Journal of Biology and Biomedical Engineering 2023, 17 , 8-15. https://doi.org/10.46300/91011.2023.17.2
    13. Qundong Liu, Katsuko Komatsu, Kazufumi Toume, Shu Zhu, Ken Tanaka, Shigeki Hayashi, Naoko Anjiki, Nobuo Kawahara, Akihito Takano, Katsunori Miyake, Norio Nakamura, Suchada Sukrong, Mangestuti Agil, Indira Balachandra. Essential oil composition of Curcuma species and drugs from Asia analyzed by headspace solid-phase microextraction coupled with gas chromatography–mass spectrometry. Journal of Natural Medicines 2023, 77 (1) , 152-172. https://doi.org/10.1007/s11418-022-01658-7
    14. Ana Paula da Costa Soares, Eliane Carvalho Minighin, Natália Cristina de Faria, Guilherme Fonseca Graciano, Tamires Cássia de Melo Souza, Lucilene Rezende Anastácio, Mariana Wanessa Santana de Souza, Cristina de Almeida Hott, Luiza Andrade Tomaz, Luciana M. Carabetti Gontijo, Ronália Leite Alvarenga, Sttefany Viana Gomes, Carolina Sheng Whei Miaw Botelho, Bárbara Chaves Santos, Alessandra Lovato, Vinícius Tadeu da Veiga Correia, Danielle Fátima D’ Angelis, Josilene Lopes de Oliveira, Ana Clara Costa Dias, Sarah Morais Senna Prates, Yassana Marvila Girondoli, Annayara Celestina Ferreira Fernandes, Renata Luana de Pádua Gandra, Anna Cláudia de Freitas e Loyola, Adriane Moreira Machado, Nayara Benedito Martins da Silva, Priscila Vaz de Melo Ribeiro, Luísa Martins Trindade, Isabel David de Matos, Kellen Pereira Bragança. ALIMENTOS COM PROPRIEDADES FUNCIONAIS E DE SAÚDE: EVIDÊNCIAS E PRETENSOS EFEITOS. 2023https://doi.org/10.36524/9788582636176
    15. Eric D. Salinas-Arellano, Ines Y. Castro-Dionicio, Jonathan G. Jeyaraj, Nathan P. Mirtallo Ezzone, Esperanza J. Carcache de Blanco. Phytochemical Profiles and Biological Studies of Selected Botanical Dietary Supplements Used in the United States. 2023, 1-162. https://doi.org/10.1007/978-3-031-26768-0_1
    16. Amner Muñoz-Acevedo, Cindy P. Guzmán, Osnaider J. Castillo, Ricardo G. Gutiérrez, Martha Cervantes-Díaz. Curcuminoids and Sesquiterpenoids from Curcuma longa Rhizomes: Can They Be the Cure for Neurodegenerative Disorders?. 2023, 127-158. https://doi.org/10.1007/978-981-99-7731-4_7
    17. Büşra Karpuz Ağören, Esra Küpeli Akkol. Secondary Metabolites of Turmeric Extract and Essential Oils. 2023, 81-99. https://doi.org/10.1007/978-981-99-7731-4_5
    18. Junyoung Park, Subeen Do, Minju Lee, Seungwoo Ha, Kwang-Geun Lee. Preparation of turmeric powder with various extraction and drying methods. Chemical and Biological Technologies in Agriculture 2022, 9 (1) https://doi.org/10.1186/s40538-022-00307-1
    19. Jianmin Sang, Jinjin Chu, Xin Zhao, Hehua Quan, Zhongyao Ji, Shaowei Wang, Yunbing Tang, Zhiyan Hu, Huitao Li, Linxi Li, Ren-shan Ge. Curcuminoids inhibit human and rat placental 3β-hydroxysteroid dehydrogenases: Structure-activity relationship and in silico docking analysis. Journal of Ethnopharmacology 2022, 307 , 116051. https://doi.org/10.1016/j.jep.2022.116051
    20. Asrin Bahmani, Zahra Najafi, Gholamabbas Chehardoli. Curcumin-Derived Heterocycles as Anticancer Agents. A Systematic Review.. Organic Preparations and Procedures International 2022, 54 (6) , 493-510. https://doi.org/10.1080/00304948.2022.2094659
    21. Nitin Sharma, Nidhi Gupta, Raha Orfali, Vikas Kumar, Chirag N. Patel, Jiangnan Peng, Shagufta Perveen. Evaluation of the Antifungal, Antioxidant, and Anti-Diabetic Potential of the Essential Oil of Curcuma longa Leaves from the North-Western Himalayas by In Vitro and In Silico Analysis. Molecules 2022, 27 (22) , 7664. https://doi.org/10.3390/molecules27227664
    22. Ann-Kathrin Widmann, Martin A. Wahl, Dietmar R. Kammerer, Rolf Daniels. Supercritical Fluid Extraction with CO2 of Curcuma longa L. in Comparison to Conventional Solvent Extraction. Pharmaceutics 2022, 14 (9) , 1943. https://doi.org/10.3390/pharmaceutics14091943
    23. Bom Nae Lee, Su Jung Hong, Mi Hee Yu, Gye Hwa Shin, Jun Tae Kim. Enhancement of Storage Stability and Masking Effect of Curcumin by Turmeric Extract-Loaded Nanoemulsion and Water-Soluble Chitosan Coating. Pharmaceutics 2022, 14 (8) , 1547. https://doi.org/10.3390/pharmaceutics14081547
    24. Tanzeel Rehman Charan, Muhammad Aqeel Bhutto, Mihr Ali Bhutto, Azhar Ali Tunio, Ghulam Murtaza, Umair Aftab, Farhartullah Kandhro, Sheeraz Ahmed Khaskheli. “Comparative analysis by total yield, antimicrobial and phytochemical evaluation of curcuminoid of district Kasur: With its potential use and characterization in electrospinning nanofibers”. Journal of Industrial Textiles 2022, 52 , 152808372211114. https://doi.org/10.1177/15280837221111457
    25. Hetvi Tambawala, Sukanya Batra, Yogita Shirapure, Aarti P. More. Curcumin- A Bio-based Precursor for Smart and Active Food Packaging Systems: A Review. Journal of Polymers and the Environment 2022, 30 (6) , 2177-2208. https://doi.org/10.1007/s10924-022-02372-x
    26. Jia De Tseng, Hung Lin Lee, Kuan Lin Yeh, Tu Lee. Recyclable positive azeotropes for the purification of curcumin with optimum purity and solvent capacity. Chemical Engineering Research and Design 2022, 180 , 200-211. https://doi.org/10.1016/j.cherd.2022.02.019
    27. Nhan Trong Le, Nguyen Thuy Hoang, Van Tuong Thi Van, Trieu Phat Dac Nguyen, Ngoc Huyen Thi Chau, Nguyen Thao Nguyen Le, Hien Bich Thi Le, Huong Thanh Phung, Hoai Thi Nguyen, Hien Minh Nguyen. Extraction of curcumin from turmeric residue ( Curcuma longa L.) using deep eutectic solvents and surfactant solvents. Analytical Methods 2022, 14 (8) , 850-858. https://doi.org/10.1039/D1AY02152D
    28. Abhineet Verma, Satyen Saha, ShobhaK Bhat. Detection of nonpermitted food color metanil yellow in turmeric: A threat to the public health and Ayurvedic drug industry. Journal of Ayurveda 2022, 16 (2) , 134. https://doi.org/10.4103/joa.joa_77_21
    29. Yuanjun Ye, Xiaoni Zhang, Xueqing Chen, Yechun Xu, Jinmei Liu, Jianjun Tan, Wei Li, Luke R. Tembrock, Zhiqiang Wu, Genfa Zhu. The use of widely targeted metabolomics profiling to quantify differences in medicinally important compounds from five Curcuma (Zingiberaceae) species. Industrial Crops and Products 2022, 175 , 114289. https://doi.org/10.1016/j.indcrop.2021.114289
    30. Song-Tao Liu, Sen-Wang Zheng, A-Jiao Hou, Jia-Xu Zhang, Song Wang, Xue-Jiao Wang, Huan Yu, Liu Yang. A review: The phytochemistry, pharmacology, and pharmacokinetics of Curcumae Longae Rhizoma (Turmeric). World Journal of Traditional Chinese Medicine 2022, 8 (4) , 463. https://doi.org/10.4103/2311-8571.351523
    31. Kraipat Cheenkachorn, Marttin Gundupalli Paulraj, Prapakorn Tantayotai, Vanarat Phakeenuya, Malinee Sriariyanun. Characterization of biologically active compounds from different herbs: Influence of drying and extraction methods. Journal of the Indian Chemical Society 2022, 99 (1) , 100297. https://doi.org/10.1016/j.jics.2021.100297
    32. Huiying Amelie Zhang, David D. Kitts. Turmeric and its bioactive constituents trigger cell signaling mechanisms that protect against diabetes and cardiovascular diseases. Molecular and Cellular Biochemistry 2021, 476 (10) , 3785-3814. https://doi.org/10.1007/s11010-021-04201-6
    33. Laura Nißl, Florian Westhaeuser, Matthias Noll. Antimycotic Effects of 11 Essential Oil Components and Their Combinations on 13 Food Spoilage Yeasts and Molds. Journal of Fungi 2021, 7 (10) , 872. https://doi.org/10.3390/jof7100872
    34. Shanshan Wang, Yun Li, Wenzhi Li, Kun Zhang, Zhengqiang Yuan, Yina Cai, Kuncheng Xu, Jinrong Zhou, Zhiyun Du. Curcuma oil ameliorates benign prostatic hyperplasia through suppression of the nuclear factor-kappa B signaling pathway in rats. Journal of Ethnopharmacology 2021, 279 , 113703. https://doi.org/10.1016/j.jep.2020.113703
    35. Hoang Le-Tan, Thomas Fauster, Jelena Vladic, Tina Gerhardt, Klara Haas, Henry Jaeger. Application of Emerging Cell Disintegration Techniques for the Accelerated Recovery of Curcuminoids from Curcuma longa. Applied Sciences 2021, 11 (17) , 8238. https://doi.org/10.3390/app11178238
    36. Rut Fernández-Marín, Susana C. M. Fernandes, María A. Andrés, Jalel Labidi. Microwave-Assisted Extraction of Curcuma longa L. Oil: Optimization, Chemical Structure and Composition, Antioxidant Activity and Comparison with Conventional Soxhlet Extraction. Molecules 2021, 26 (6) , 1516. https://doi.org/10.3390/molecules26061516
    37. Abdalla El‐Hadary, Mahmoud Sitohy. Safely effective hypoglycemic action of stevia and turmeric extracts on diabetic Albino rats. Journal of Food Biochemistry 2021, 45 (1) https://doi.org/10.1111/jfbc.13549
    38. Jennifer Widjaja, Indeswati Diyatri, Wibi Riawan, Astari Puteri, Asti Meizarini. New insight into the role of a combination of zinc oxide and turmeric rhizome liquid extract in osteogenic marker expression. The Journal of Indian Prosthodontic Society 2021, 21 (3) , 262. https://doi.org/10.4103/jips.jips_120_21
    39. Abhay K. Pandey, Ana Sanches Silva, Richa Varshney, Mónica L. Chávez-González, Pooja Singh. Curcuma-based botanicals as crop protectors: From knowledge to application in food crops. Current Research in Biotechnology 2021, 3 , 235-248. https://doi.org/10.1016/j.crbiot.2021.07.004
    40. Josemar Gonçalves de Oliveira Filho, Micael José de Almeida, Tainara Leal Sousa, Daiane Costa dos Santos, Mariana Buranelo Egea. Bioactive Compounds of Turmeric (Curcuma longa L.). 2021, 297-318. https://doi.org/10.1007/978-3-030-57415-4_37
    41. Ritu Mishra, Anil K. Gupta. Biological Activities of Curcuminoids. 2020, 172-195. https://doi.org/10.1039/9781788015936-00172
    42. Francisco Allan L. de Carvalho, Paulo E.S. Munekata, Alessandra Lopes de Oliveira, Mirian Pateiro, Rubén Domínguez, Marco Antonio Trindade, José M. Lorenzo. Turmeric (Curcuma longa L.) extract on oxidative stability, physicochemical and sensory properties of fresh lamb sausage with fat replacement by tiger nut (Cyperus esculentus L.) oil. Food Research International 2020, 136 , 109487. https://doi.org/10.1016/j.foodres.2020.109487
    43. Fatemeh Jamshidi-kia, Joko Priyanto Wibowo, Mostafa Elachouri, Rohollah Masumi, Alizamen Salehifard-Jouneghani, Zohreh Abolhasanzadeh, Zahra Lorigooini. Battle between plants as antioxidants with free radicals in human body. Journal of Herbmed Pharmacology 2020, 9 (3) , 191-199. https://doi.org/10.34172/jhp.2020.25
    44. Marek Kieliszek, Amr Edris, Anna Maria Kot, Kamil Piwowarek. Biological Activity of Some Aromatic Plants and Their Metabolites, with an Emphasis on Health-Promoting Properties. Molecules 2020, 25 (11) , 2478. https://doi.org/10.3390/molecules25112478
    45. Isaac R. Rukundo, Mary-Grace C. Danao. Identifying Turmeric Powder by Source and Metanil Yellow Adulteration Levels Using Near-Infrared Spectra and PCA-SIMCA Modeling. Journal of Food Protection 2020, 83 (6) , 968-974. https://doi.org/10.4315/JFP-19-515
    46. . Curcuma Species. 2020, 408-425. https://doi.org/10.1002/9783527825578.c02-35
    47. Isaac R Rukundo, Mary-Grace C Danao, Curtis L Weller, Randy L Wehling, Kent M Eskridge. Use of a handheld near infrared spectrometer and partial least squares regression to quantify metanil yellow adulteration in turmeric powder. Journal of Near Infrared Spectroscopy 2020, 28 (2) , 81-92. https://doi.org/10.1177/0967033519898889
    48. Rodrigo Abonia, Kenneth K. Laali, Dawn Raja Somu, Scott D. Bunge, Esther C. Wang. A Flexible Strategy for Modular Synthesis of Curcuminoid‐BF 2 /Curcuminoid Pairs and Their Comparative Antiproliferative Activity in Human Cancer Cell Lines. ChemMedChem 2020, 15 (4) , 354-362. https://doi.org/10.1002/cmdc.201900640
    49. Josemar Gonçalves de Oliveira Filho, Micael José de Almeida, Tainara Leal Sousa, Daiane Costa dos Santos, Mariana Buranelo Egea. Bioactive Compounds of Turmeric (Curcuma longa L.). 2020, 1-22. https://doi.org/10.1007/978-3-030-44578-2_37-1
    50. Wan-Jun Lee, Norhidayah Suleiman, Noor Hadzuin Nik Hadzir, Gun-Hean Chong. Supercritical fluids for the extraction of oleoresins and plant phenolics. 2020, 279-328. https://doi.org/10.1016/B978-0-12-817388-6.00012-X
    51. Delia Rita Tapia-Blácido, Marcia Eliana da Silva Ferreira, Guilherme José Aguilar, Denis Jansen Lemos Costa. Biodegradable packaging antimicrobial activity. 2020, 207-238. https://doi.org/10.1016/B978-0-12-818795-1.00009-5
    52. Diana Paola Nobile Correa, Jaime Restrepo Osorio, Orlando Zúñiga, Ruben Albeiro Sánchez Andica. Determination of nutritional value of turmeric flour and the antioxidant activity of Curcuma longa rhizome extracts from agroecological and conventional crops of Valle del Cauca-Colombia. Revista Colombiana de Química 2020, 49 (1) , 26-32. https://doi.org/10.15446/rev.colomb.quim.v1n49.79334
    53. R. Abel C. Torres, Ádina L. Santana, Diego T. Santos, Juliana Q. Albarelli, M. Angela A. Meireles. A novel process for CO2 purification and recycling based on subcritical adsorption in oat bran. Journal of CO2 Utilization 2019, 34 , 362-374. https://doi.org/10.1016/j.jcou.2019.06.022
    54. Jingru Sun, Guanghong Cui, Xiaohui Ma, Zhilai Zhan, Ying Ma, Zhongqiu Teng, Wei Gao, Yanan Wang, Tong Chen, Changjiangsheng Lai, Yujun Zhao, Jinfu Tang, Huixin Lin, Ye Shen, Wen Zeng, Juan Guo, Luqi Huang. An integrated strategy to identify genes responsible for sesquiterpene biosynthesis in turmeric. Plant Molecular Biology 2019, 101 (3) , 221-234. https://doi.org/10.1007/s11103-019-00892-0
    55. Andréia Dalla Rosa, Alexander Junges, Ilizandra Aparecida Fernandes, Rogério Luis Cansian, Marcos L. Corazza, Elton Franceschi, Geciane Toniazzo Backes, Eunice Valduga. High pressure extraction of olive leaves (Olea europaea): bioactive compounds, bioactivity and kinetic modelling. Journal of Food Science and Technology 2019, 56 (8) , 3864-3876. https://doi.org/10.1007/s13197-019-03856-w
    56. Dasharath Kondhare, Sushma Deshmukh, Harshad Lade. Curcumin Analogues with Aldose Reductase Inhibitory Activity: Synthesis, Biological Evaluation, and Molecular Docking. Processes 2019, 7 (7) , 417. https://doi.org/10.3390/pr7070417
    57. E.A. Flores-Frias, V. Barba, M.A. Lucio-Garcia, R. Lopez-Cecenes, J. Porcayo-Calderon, J.G. Gonzalez-Rodriguez. Use of Curcuma and Curcumin as a Green Corrosion Inhibitors for carbon Steel in Sulfuric Acid. International Journal of Electrochemical Science 2019, 14 (6) , 5026-5041. https://doi.org/10.20964/2019.06.53
    58. Fatemeh Ghaffarian, Mohammad Ali Ghasemzadeh, Seyyed Soheil Aghaei. An efficient synthesis of some new curcumin based pyrano[2,3-d]pyrimidine-2,4(3H)-dione derivatives using CoFe2O4@OCMC@Cu(BDC) as a novel and recoverable catalyst. Journal of Molecular Structure 2019, 1186 , 204-211. https://doi.org/10.1016/j.molstruc.2019.03.029
    59. Jesmin Akter, Md. Zahorul Islam, Kensaku Takara, Md. Amzad Hossain, Ayako Sano. Isolation and structural elucidation of antifungal compounds from Ryudai gold (Curcuma longa) against Fusarium solani sensu lato isolated from American manatee. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2019, 219 , 87-94. https://doi.org/10.1016/j.cbpc.2019.02.011
    60. Chang Yang Park, Kyo-Yeon Lee, Khalid Gul, M. Shafiur Rahman, Ah-Na Kim, Jiyeon Chun, Hyun-Jin Kim, Sung-Gil Choi. Phenolics and antioxidant activity of aqueous turmeric extracts as affected by heating temperature and time. LWT 2019, 105 , 149-155. https://doi.org/10.1016/j.lwt.2019.02.014
    61. Fatemeh Momenkiaei, Farhad Raofie. Preparation of Curcuma Longa L. Extract Nanoparticles Using Supercritical Solution Expansion. Journal of Pharmaceutical Sciences 2019, 108 (4) , 1581-1589. https://doi.org/10.1016/j.xphs.2018.11.010
    62. T H Tran, P T N Nguyen, T N Pham, D C Nguyen, T P Dao, T D Nguyen, D H Nguyen, D V N Vo, X T Le, N T H Le, L G Bach. Green technology to optimize the extraction process of turmeric (Curcuma longa L.) oils. IOP Conference Series: Materials Science and Engineering 2019, 479 , 012002. https://doi.org/10.1088/1757-899X/479/1/012002
    63. Noura Dosoky, Prabodh Satyal, William Setzer. Variations in the Volatile Compositions of Curcuma Species. Foods 2019, 8 (2) , 53. https://doi.org/10.3390/foods8020053
    64. Alexander V. Zholos, Olesia F. Moroz, Maksim V. Storozhuk. Curcuminoids and Novel Opportunities for the Treatment of Alzheimer's Disease: Which Molecules are Actually Effective?. Current Molecular Pharmacology 2019, 12 (1) , 12-26. https://doi.org/10.2174/1874467211666181012150847
    65. Solomon Habtemariam. The chemical and pharmacological basis of turmeric (Curcuma longa L.) as potential therapy for type 2 diabetes and metabolic syndrome. 2019, 751-789. https://doi.org/10.1016/B978-0-08-102922-0.00020-1
    66. Mara E.M. Braga, Sócrates Quispe-Condori, Paulo T.V. Rosa, M. Angela A. Meireles. Mathematical modelling of turmeric compounds extraction using high pressurized solvents mixture. The Journal of Supercritical Fluids 2018, 140 , 348-355. https://doi.org/10.1016/j.supflu.2018.07.014
    67. Noura Dosoky, William Setzer. Chemical Composition and Biological Activities of Essential Oils of Curcuma Species. Nutrients 2018, 10 (9) , 1196. https://doi.org/10.3390/nu10091196
    68. M. L. Alvarado-Noguez, C. Hernández-Aguilar, F. A. Domínguez-Pacheco, A. Cruz-Orea, F. Sánchez-Sinéncio. Photothermal Techniques Applied to the Thermal and Optical Characterization of Curcuma longa. International Journal of Thermophysics 2018, 39 (8) https://doi.org/10.1007/s10765-018-2418-8
    69. Swati Gupta, Hafsa Ahmad, Babita Shukla, Neha Ojha, Anil K. Dwivedi. Isolation, Structural Characterization, and Validation of a New Compound Present in Non‐Carbonyl Curcuma longa (NCCL): A Potential Lead for Stroke. Journal of Heterocyclic Chemistry 2018, 55 (8) , 1926-1934. https://doi.org/10.1002/jhet.3230
    70. Guang-Ping Lv, De-Jun Hu, Yan-Qing Zhou, Qing-Wen Zhang, Jing Zhao, Shao-Ping Li. Preparation and Application of Standardized Typical Volatile Components Fraction from Turmeric (Curcuma longa L.) by Supercritical Fluid Extraction and Step Molecular Distillation. Molecules 2018, 23 (7) , 1831. https://doi.org/10.3390/molecules23071831
    71. Inyoung Choi, Sang Eun Lee, Yoonjee Chang, Monique Lacroix, Jaejoon Han. Effect of oxidized phenolic compounds on cross-linking and properties of biodegradable active packaging film composed of turmeric and gelatin. LWT 2018, 93 , 427-433. https://doi.org/10.1016/j.lwt.2018.03.065
    72. Meghan B. Skiba, Paula B. Luis, Chelsea Alfafara, Dean Billheimer, Claus Schneider, Janet L. Funk. Curcuminoid Content and Safety‐Related Markers of Quality of Turmeric Dietary Supplements Sold in an Urban Retail Marketplace in the United States. Molecular Nutrition & Food Research 2018, 62 (14) https://doi.org/10.1002/mnfr.201800143
    73. Ádina Lima de SANTANA, Juan Felipe OSORIO-TOBÓN, Fiorella Patricia CÁRDENAS-TORO, Caroline Joy STEEL, Maria Angela de Almeida MEIRELES. Partial-hydrothermal hydrolysis is an effective way to recover bioactives from turmeric wastes. Food Science and Technology 2018, 38 (2) , 280-292. https://doi.org/10.1590/1678-457x.22016
    74. Maria Mantzorou, Eleni Pavlidou, George Vasios, Eftychia Tsagalioti, Constantinos Giaginis. Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data. Phytotherapy Research 2018, 32 (6) , 957-975. https://doi.org/10.1002/ptr.6037
    75. Göksu Basmaz, Naciye Öztürk. Determination of Curcumin in Turmeric Sample Using Edge Plane Pyrolytic Graphite Electrode. Celal Bayar Üniversitesi Fen Bilimleri Dergisi 2017, , 689-694. https://doi.org/10.18466/cbayarfbe.339339
    76. Lanyue Zhang, Zhiwen Yang, Jingwen Wei, Ping Su, Wanyi Pan, Xi Zheng, Kun Zhang, Li Lin, Jian Tang, Yanxiong Fang, Zhiyun Du. Essential oil composition and bioactivity variation in wild-growing populations of Curcuma phaeocaulis Valeton collected from China. Industrial Crops and Products 2017, 103 , 274-282. https://doi.org/10.1016/j.indcrop.2017.04.019
    77. Pollyanna de Moraes França Ferreira, Juliana Silva Rocha, Juliana Rodrigues Gomes, Débora Werneck Caldas, Maria Tatiana Soares Martins, Jerusa Maria de Oliveira, Ana Lucia Salaro, Jener Alexandre Sampaio Zuanon. Curcuma longa supplementation in the diet of Astyanax aff . bimaculatus in preparation for transport. Aquaculture Research 2017, 48 (8) , 4524-4532. https://doi.org/10.1111/are.13277
    78. Pouya Mottahedin, Ali Haghighi Asl, Maryam Khajenoori. Extraction of Curcumin and Essential Oil from Curcuma longa L. by Subcritical Water via Response Surface Methodology. Journal of Food Processing and Preservation 2017, 41 (4) , e13095. https://doi.org/10.1111/jfpp.13095
    79. Hui Liang, Wenchao Wang, Jialin Xu, Qing Zhang, Zheluan Shen, Zhen Zeng, Qingyong Li. Optimization of ionic liquid-based microwave-assisted extraction technique for curcuminoids from Curcuma longa L.. Food and Bioproducts Processing 2017, 104 , 57-65. https://doi.org/10.1016/j.fbp.2017.04.003
    80. Wen Sun, Sheng Wang, Wenwen Zhao, Chuanhong Wu, Shuhui Guo, Hongwei Gao, Hongxun Tao, Jinjian Lu, Yitao Wang, Xiuping Chen. Chemical constituents and biological research on plants in the genus Curcuma. Critical Reviews in Food Science and Nutrition 2017, 57 (7) , 1451-1523. https://doi.org/10.1080/10408398.2016.1176554
    81. A B D Nandiyanto, A S Wiryani, A Rusli, A Purnamasari, A G Abdullah, Ana, I Widiaty, R Hurriyati. Extraction of Curcumin Pigment from Indonesian Local Turmeric with Its Infrared Spectra and Thermal Decomposition Properties. IOP Conference Series: Materials Science and Engineering 2017, 180 , 012136. https://doi.org/10.1088/1757-899X/180/1/012136
    82. Alireza Khorshidi, Nura Sadeghi. Application of trans-[ZrO(curcumin)2(H2O)]·H2O in coloration of cotton fibers. Research on Chemical Intermediates 2017, 43 (2) , 1223-1233. https://doi.org/10.1007/s11164-016-2694-5
    83. Hugo A. Martinez-Correa, Julia T. Paula, Ana Carolina A.V. Kayano, Carmen L. Queiroga, Pedro M. Magalhães, Fabio T.M. Costa, Fernando A. Cabral. Composition and antimalarial activity of extracts of Curcuma longa L. obtained by a combination of extraction processes using supercritical CO2, ethanol and water as solvents. The Journal of Supercritical Fluids 2017, 119 , 122-129. https://doi.org/10.1016/j.supflu.2016.08.017
    84. Elwira Sieniawska, Tomasz Baj, Rafal Sawicki, Aleksandra Wanat, Krzysztof Kamil Wojtanowski, Grazyna Ginalska, Grazyna Zgorka, Jolanta Szymanska. LC-QTOF-MS Analysis and Activity Profiles of Popular Antioxidant Dietary Supplements in Terms of Quality Control. Oxidative Medicine and Cellular Longevity 2017, 2017 , 1-11. https://doi.org/10.1155/2017/8692516
    85. Swarrna Haldar, Hari Niwas Mishra, Gautam Chandra Majumdar. Optimization of Oleoresin Extraction from Curcuma longa L. Using RSM and Determination of Equilibrium Constant. Journal of Food Processing and Preservation 2016, 40 (6) , 1188-1198. https://doi.org/10.1111/jfpp.12701
    86. Shinichi Matsumura, Kazuya Murata, Nobuhiro Zaima, Yuri Yoshioka, Masanori Morimoto, Hirona Kugo, Ayami Yamamoto, Tatsuya Moriyama, Hideaki Matsuda. Inhibitory Activities of Essential Oil Obtained from Turmeric and Its Constituents against β-Secretase. Natural Product Communications 2016, 11 (12) , 1934578X1601101. https://doi.org/10.1177/1934578X1601101203
    87. Rajarshi Biswas, Pulok K. Mukherjee, Amit Kar, Shiv Bahadur, Ranjit K. Harwansh, Sayan Biswas, Naif Abdullah Al-Dhabi, V. Duraipandiyan. Evaluation of Ubtan – A traditional indian skin care formulation. Journal of Ethnopharmacology 2016, 192 , 283-291. https://doi.org/10.1016/j.jep.2016.07.034
    88. Jaggi Lal, Sushil K. Gupta, D. Thavaselvam, Dau D. Agarwal. Synthesis and pharmacological activity evaluation of curcumin derivatives. Chinese Chemical Letters 2016, 27 (7) , 1067-1072. https://doi.org/10.1016/j.cclet.2016.03.032
    89. Natcha Laokuldilok, Prodpran Thakeow, Phikunthong Kopermsub, Niramon Utama-ang. Optimisation of microencapsulation of turmeric extract for masking flavour. Food Chemistry 2016, 194 , 695-704. https://doi.org/10.1016/j.foodchem.2015.07.150
    90. T. K. Lim. Curcuma longa. 2016, 241-362. https://doi.org/10.1007/978-3-319-26065-5_14
    91. B.C. Maniglia, R.L. de Paula, J.R. Domingos, D.R. Tapia-Blácido. Turmeric dye extraction residue for use in bioactive film production: Optimization of turmeric film plasticized with glycerol. LWT - Food Science and Technology 2015, 64 (2) , 1187-1195. https://doi.org/10.1016/j.lwt.2015.07.025
    92. Yi Zhao, Dallas Donohoe, E-Chu Huang, Jay Whelan. Zyflamend, a polyherbal mixture, inhibits lipogenesis and mTORC1 signalling via activation of AMPK. Journal of Functional Foods 2015, 18 , 147-158. https://doi.org/10.1016/j.jff.2015.06.051
    93. Pedro I.N. Carvalho, J. Felipe Osorio-Tobón, Mauricio A. Rostagno, Ademir J. Petenate, M. Angela A. Meireles. Techno-economic evaluation of the extraction of turmeric (Curcuma longa L.) oil and ar-turmerone using supercritical carbon dioxide. The Journal of Supercritical Fluids 2015, 105 , 44-54. https://doi.org/10.1016/j.supflu.2015.03.020
    94. Grace Gar-Lee Yue, Hin-Fai Kwok, Julia Kin-Ming Lee, Lei Jiang, Kar-Man Chan, Ling Cheng, Eric Chun-Wai Wong, Ping-Chung Leung, Kwok-Pui Fung, Clara Bik-San Lau. Novel anti-angiogenic effects of aromatic-turmerone, essential oil isolated from spice turmeric. Journal of Functional Foods 2015, 15 , 243-253. https://doi.org/10.1016/j.jff.2015.03.030
    95. Swarrna Haldar, Gautam Chandra Majumdar, Hari Niwas Mishra. Modeling the kinetics of extracting oleoresin from dried turmeric (Curcuma longa L.) rhizome using acetone as solvent. Journal of Food Engineering 2015, 146 , 116-121. https://doi.org/10.1016/j.jfoodeng.2014.09.009
    96. P. C. Lekshmi, Ranjith Arimboor, V. M. Nisha, A. Nirmala Menon, K. G. Raghu. In vitro antidiabetic and inhibitory potential of turmeric (Curcuma longa L) rhizome against cellular and LDL oxidation and angiotensin converting enzyme. Journal of Food Science and Technology 2014, 51 (12) , 3910-3917. https://doi.org/10.1007/s13197-013-0953-7
    97. R. Akloul, F. Benkaci-Ali, G. Eppe. Kinetic study of volatile oil of Curcuma longa L. rhizome and Carum carvi L. fruits extracted by microwave-assisted techniques using the cryogrinding. Journal of Essential Oil Research 2014, 26 (6) , 473-485. https://doi.org/10.1080/10412905.2014.942766
    98. Zed Daliela Zulkafli, Hui Wang, Fumie Miyashita, Nobutoshi Utsumi, Kazuhiro Tamura. Cosolvent-modified supercritical carbon dioxide extraction of phenolic compounds from bamboo leaves (Sasa palmata). The Journal of Supercritical Fluids 2014, 94 , 123-129. https://doi.org/10.1016/j.supflu.2014.07.008
    99. Huijin Fan, Weixi Tian, Xiaofeng Ma. Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid synthase. Targeted Oncology 2014, 9 (3) , 279-286. https://doi.org/10.1007/s11523-013-0286-5
    100. M.M.R. de Melo, A.J.D. Silvestre, C.M. Silva. Supercritical fluid extraction of vegetable matrices: Applications, trends and future perspectives of a convincing green technology. The Journal of Supercritical Fluids 2014, 92 , 115-176. https://doi.org/10.1016/j.supflu.2014.04.007
    Load all citations

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    MENDELEY PAIRING EXPIRED
    Your Mendeley pairing has expired. Please reconnect