Gastric secretion : Current Opinion in Gastroenterology

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STOMACH AND DUODENUM: Edited by Mitchell L. Schubert

Gastric secretion

Schubert, Mitchell L.a,b

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Current Opinion in Gastroenterology 30(6):p 578-582, November 2014. | DOI: 10.1097/MOG.0000000000000125

Abstract

Purpose of review 

This review summarizes the past year's literature regarding the neural, paracrine, hormonal, and intracellular regulation of gastric acid secretion.

Recent findings 

Gastric acid facilitates the digestion of protein as well as the absorption of iron, calcium, vitamin B12, and certain medications. High gastric acidity, in combination with pepsin and lipase, kills ingested microorganisms and may play a role in preventing bacterial overgrowth, enteric infection, and possibly spontaneous bacterial peritonitis, community-acquired pneumonia, and infection with Mycobacterium tuberculosis. Stimulants of acid secretion include histamine, gastrin, acetylcholine, and ghrelin. Inhibitors include somatostatin, gastric inhibitory polypeptide, calcitonin gene-related peptide, and adrenomedullin. Helicobacter pylori stimulates or inhibits depending upon the time course of infection and the area of the stomach predominantly infected. Proteins implicated in H-K-ATPase membrane trafficking include myosin IIB, F-actin, ezrin, and Rab GTPases.

Summary 

Our understanding of the regulation of gastric acid secretion continues to advance. Such knowledge is crucial for the management of acid-peptic disorders and the development of novel medications, such as cholecystokinin-2 receptor antagonists.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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