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Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

J. William Langston, Philip Ballard, James W. Tetrud, and Ian IrwinAuthors Info & Affiliations
Science
25 Feb 1983
Vol 219, Issue 4587
pp. 979-980
DOI: 10.1126/science.6823561
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Abstract

Four persons developed marked parkinsonism after using an illicit drug intravenously. Analysis of the substance injected by two of these patients revealed primarily 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) with trace amounts of 1-methyl-4-phenyl-4-propionoxy-piperidine (MPPP). On the basis of the striking parkinsonian features observed in our patients, and additional pathological data from one previously reported case, it is proposed that this chemical selectively damages cells in the substantia nigra.

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References

DAVIS, G.C., CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS, PSYCHIATRY RESEARCH 1: 249 (1979).
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GOLDSTEIN, J.E., APRAXIA OF LID OPENING, ARCHIVES OF OPHTHALMOLOGY 73: 155 (1965).
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ZIERING, A, PIPERIDINE DERIVATIVES .3. 4-ARYLPIPERIDINES, JOURNAL OF ORGANIC CHEMISTRY 12: 894 (1947).
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Science
Volume 219 | Issue 4587
25 February 1983

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© 1983.

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Published in print: 25 February 1983

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J. William Langston
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Department of Neurology, Stanford University School of Medicine, Stanford, California 94105, and Santa Clara Valley Medical Center, San Jose, California 95128
612 Frederick Street, Santa Cruz, California 95062
Drug Assay Laboratory, Stanford University Hospital, Stanford, California 94305

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  • J. William Langston et al.
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Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis.Science219,979-980(1983).DOI:10.1126/science.6823561

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