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First published online April 16, 2015

Reactive nitrogen species in cellular signaling

Abstract

The transduction of cellular signals occurs through the modification of target molecules. Most of these modifications are transitory, thus the signal transduction pathways can be tightly regulated. Reactive nitrogen species are a group of compounds with different properties and reactivity. Some reactive nitrogen species are highly reactive and their interaction with macromolecules can lead to permanent modifications, which suggested they were lacking the specificity needed to participate in cell signaling events. However, the perception of reactive nitrogen species as oxidizers of macromolecules leading to general oxidative damage has recently evolved. The concept of redox signaling is now well established for a number of reactive oxygen and nitrogen species. In this context, the post-translational modifications introduced by reactive nitrogen species can be very specific and are active participants in signal transduction pathways. This review addresses the role of these oxidative modifications in the regulation of cell signaling events.

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Article first published online: April 16, 2015
Issue published: June 2015

Keywords

  1. Nitric oxide
  2. nitrosylation
  3. nitration
  4. cell signaling

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© 2015 by the Society for Experimental Biology and Medicine.

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Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32827, USA

Notes

Alvaro G. Estevez. Email: [email protected]

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All authors participated in the writing of this manuscript.

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