Establishing the triplet nature of the genetic code

Charles Yanofsky

doi:10.1016/j.cell.2007.02.029

Establishing the triplet nature of the genetic code

Cell. 2007 Mar 9;128(5):815-8. doi: 10.1016/j.cell.2007.02.029.

Author

Charles Yanofsky¹

Affiliation

¹ Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.

PMID: 17350564
DOI: 10.1016/j.cell.2007.02.029

Abstract

In 1961, Crick, Barnett, Brenner, and Watts-Tobin (Crick et al., 1961) designed an elegant experimental strategy to determine the nature of the genetic code. Remarkably, they reached the correct conclusion despite the absence of technology to analyze and compare DNA and protein sequences.

Publication types

Historical Article

MeSH terms

Amino Acid Sequence
Bacteriophage T4 / genetics
Base Sequence
DNA / chemistry
DNA / history
Genetic Code*
Genetic Techniques / history
History, 20th Century
Molecular Biology / history*
Mutation
Proteins / chemistry
Research Design

Substances

Proteins
DNA