Mechanisms and results of the antibody-dependent enhancement of viral infections and role in the pathogenesis of coxsackievirus B-induced diseases

Microbes Infect. 2009 Apr;11(4):443-51. doi: 10.1016/j.micinf.2009.01.005.

Abstract

The mechanisms of the antibody-dependent enhancement (ADE) of viral infection are presented, particularly within the Picornaviridae family. The ADE of infection has been described in both human and animal models, worsens viral infections and compromises vaccine safety. The ADE of coxsackievirus B infection can also be implied in the pathogenesis of diseases like chronic dilated cardiomyopathy or insulin-dependent type 1 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibody-Dependent Enhancement*
  • Cardiomyopathy, Dilated / etiology*
  • Coxsackievirus Infections / complications*
  • Coxsackievirus Infections / immunology*
  • Diabetes Mellitus, Type 1 / etiology*
  • Enterovirus B, Human / immunology*
  • Humans