Psychiatric Manifestation in Patients with Parkinson's Disease

J Korean Med Sci. 2018 Nov 1;33(47):e300. doi: 10.3346/jkms.2018.33.e300. eCollection 2018 Nov 19.

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Although its major manifestation is motor symptoms, resulting from the loss of dopaminergic neurons in the substantia nigra, psychiatric symptoms, such as depression, anxiety, hallucination, delusion, apathy and anhedonia, impulsive and compulsive behaviors, and cognitive dysfunction, may also manifest in most patients with PD. Given that the quality of life - and the need for institutionalization - is so highly dependent on the psychiatric well-being of patients with PD, psychiatric symptoms are of high clinical significance. We reviewed the prevalence, risk factors, pathophysiology, and treatment of psychiatric symptoms to get a better understanding of PD for improved management.

Keywords: Dementia; Depression; Impulse Control Disorder; Parkinson's Disease; Psychiatry; Psychosis.

Publication types

  • Review

MeSH terms

  • Anxiety / diagnosis*
  • Anxiety / epidemiology
  • Dementia / diagnosis*
  • Dementia / epidemiology
  • Depression / diagnosis*
  • Depression / drug therapy
  • Depression / epidemiology
  • Disruptive, Impulse Control, and Conduct Disorders / diagnosis
  • Disruptive, Impulse Control, and Conduct Disorders / epidemiology
  • Dopamine / therapeutic use
  • Humans
  • Parkinson Disease / pathology*
  • Parkinson Disease / psychology
  • Psychotic Disorders / diagnosis
  • Psychotic Disorders / drug therapy
  • Psychotic Disorders / epidemiology
  • Selective Serotonin Reuptake Inhibitors / therapeutic use
  • Serotonin 5-HT2 Receptor Antagonists / therapeutic use

Substances

  • Serotonin 5-HT2 Receptor Antagonists
  • Serotonin Uptake Inhibitors
  • Dopamine