Antivirals With Adjunctive Corticosteroids Prevent Clinical Progression of Early Coronavirus 2019 Pneumonia: A Retrospective Cohort Study

Say Tat Ooi; Purnima Parthasarathy; Yi Lin; Valliammai D/O Nallakaruppan; Shereen Ng; Teck Choon Tan; Serena Low; Terence Tang

doi:10.1093/ofid/ofaa486

Antivirals With Adjunctive Corticosteroids Prevent Clinical Progression of Early Coronavirus 2019 Pneumonia: A Retrospective Cohort Study

Open Forum Infect Dis. 2020 Oct 14;7(11):ofaa486. doi: 10.1093/ofid/ofaa486. eCollection 2020 Nov.

Authors

Say Tat Ooi^{1 2}, Purnima Parthasarathy¹, Yi Lin², Valliammai D/O Nallakaruppan³, Shereen Ng³, Teck Choon Tan⁴, Serena Low⁵, Terence Tang⁶

Affiliations

¹ Division of Infectious Diseases, Department of General Medicine, Khoo Teck Puat Hospital, Singapore.
² Clinical Epidemiology Unit, Khoo Teck Puat Hospital, Singapore.
³ Division of General Medicine, Department of General Medicine, Khoo Teck Puat Hospital, Singapore.
⁴ Division of Rheumatology, Department of General Medicine, Khoo Teck Puat Hospital, Singapore.
⁵ Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
⁶ Department of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore.

Abstract

This is a retrospective cohort study of hospitalized adults with coronavirus disease 2019 (COVID-19). Fifty-seven patients received treatment alone, and 35 patients received treatment with adjunctive prednisolone. A combination of corticosteroids and antivirals was associated with lower risk of clinical progression and invasive mechanical ventilation or death in early COVID-19 pneumonia.

Keywords: COVID-19; corticosteroids; hydroxychloroquine.