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Glutathione S-transferase M1, T1, and P1 gene polymorphisms and carotid atherosclerosis in Korean patients with rheumatoid arthritis

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Abstract

We assessed the contribution of genetic polymorphisms of glutathione S-transferase M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1, Ile105Val) to carotid atherosclerosis in 40 postmenopausal rheumatoid arthritic (RA) women without histories of smoking. We measured mean intima-media thickness (IMT) and plaque of the common carotid arteries by ultrasonography and evaluated relationships among the known risk factors for atherosclerosis, genetic polymorphisms, RA outcomes, and markers of inflammation. Subjects with the GSTT1–0 genotype had greater IMT (P<0.05). On univariate analysis, carotid IMT was positively associated with age, systolic BP, antihypertensive drug use, and the GSTT1–0 genotype (P<0.05). When compared to subjects with a double-positive GSTM1/T1 genotype, IMT in those with concurrent lack of the GSTM1 and GSTT1 genes was significantly increased (P=0.008). This study suggests that the GSTT1–0 genotype might have an interaction with carotid atherosclerosis related to RA in Korean postmenopausal RA women without histories of smoking.

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Acknowledgements

This work was supported by a grant from the Korea Health 21 Research and Development Project, Ministry of Health and Welfare, Republic of Korea (01-PJ3-PG6–01GN11–0002). We gratefully acknowledge Eun-Joo Kwak for her data management and statistical analyses.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Hanyang University College of Medicine and the Hospital for Rheumatic Diseases, Seoul 133–792, Korea

    Jae-Hong Park & Sang-Cheol Bae

  2. Department of Nutritional Sciences, University of Toronto, Toronto, Canada

    Ahmed El-Sohemy & Marilyn C. Cornelis

  3. Hallym University, Kangdong Sacred Heart Hospital, Seoul, Korea

    Hyun-Ah Kim

  4. Department of Orthopedic Surgery, College of Medicine, Kyungpook National University, Daegu, Korea

    Shin-Yoon Kim

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  1. Jae-Hong Park
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  2. Ahmed El-Sohemy
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  5. Shin-Yoon Kim
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Correspondence to Sang-Cheol Bae.

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Park, JH., El-Sohemy, A., Cornelis, M.C. et al. Glutathione S-transferase M1, T1, and P1 gene polymorphisms and carotid atherosclerosis in Korean patients with rheumatoid arthritis. Rheumatol Int 24, 157–163 (2004). https://doi.org/10.1007/s00296-003-0347-7

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  • DOI: https://doi.org/10.1007/s00296-003-0347-7

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