Procoagulant microparticles: a possible link between vaccine-induced immune thrombocytopenia (VITT) and cerebral sinus venous thrombosis

J Thromb Thrombolysis. 2021 Oct;52(3):689-691. doi: 10.1007/s11239-021-02505-4. Epub 2021 Jun 15.
No abstract available

Keywords: COVID-19; Microparticles; PF4; Thrombocytopenia; Thrombosis; Vaccine.

Publication types

  • Letter

MeSH terms

  • Ad26COVS1
  • Autoantibodies / blood
  • Blood Coagulation / drug effects*
  • Blood Platelets / drug effects*
  • Blood Platelets / immunology
  • Blood Platelets / metabolism
  • COVID-19 Vaccines / administration & dosage
  • COVID-19 Vaccines / adverse effects*
  • Cell-Derived Microparticles / drug effects*
  • Cell-Derived Microparticles / immunology
  • Cell-Derived Microparticles / metabolism
  • ChAdOx1 nCoV-19
  • Female
  • Humans
  • Male
  • Middle Aged
  • Phosphatidylserines / metabolism
  • Platelet Factor 4 / immunology
  • Purpura, Thrombocytopenic, Idiopathic / blood
  • Purpura, Thrombocytopenic, Idiopathic / chemically induced*
  • Purpura, Thrombocytopenic, Idiopathic / diagnosis
  • Purpura, Thrombocytopenic, Idiopathic / immunology
  • Receptors, IgG / metabolism
  • Risk Factors
  • Sinus Thrombosis, Intracranial / blood
  • Sinus Thrombosis, Intracranial / chemically induced*
  • Sinus Thrombosis, Intracranial / diagnosis
  • Thromboplastin / metabolism
  • Vaccination / adverse effects*

Substances

  • Ad26COVS1
  • Autoantibodies
  • COVID-19 Vaccines
  • FCGR2A protein, human
  • PF4 protein, human
  • Phosphatidylserines
  • Receptors, IgG
  • Platelet Factor 4
  • Thromboplastin
  • ChAdOx1 nCoV-19