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2000 1
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Young@Heart: empowering the next generation of cardiovascular researchers.
Hoes MF, Te Riele ASJM, Gladka MM, Westenbrink BD, van Hout GPJ, van den Hoogenhof MMG, Ghigo A, Bollini S, Purcell NH, Sohaib SMA, Kardys I, Kuster DWD. Hoes MF, et al. Neth Heart J. 2020 Aug;28(Suppl 1):25-30. doi: 10.1007/s12471-020-01454-6. Neth Heart J. 2020. PMID: 32780328 Free PMC article. Review.
Is the brain involved in patients with late-onset Pompe disease?
van den Dorpel JJA, van der Vlugt WMC, Dremmen MHG, Muetzel R, van den Berg E, Hest R, de Kriek J, Brusse E, van Doorn PA, van der Ploeg AT, van den Hout JMP, van der Beek NAME. van den Dorpel JJA, et al. J Inherit Metab Dis. 2022 May;45(3):493-501. doi: 10.1002/jimd.12469. Epub 2022 Jan 25. J Inherit Metab Dis. 2022. PMID: 34927739 Free PMC article.
Neurofilament Light and Its Association With CNS Involvement in Patients With Classic Infantile Pompe Disease.
Mackenbach MJ, Willemse EAJ, van den Dorpel JJA, van der Beek NAME, Díaz-Manera J, Rizopoulos D, Teunissen C, van der Ploeg AT, van den Hout JMP. Mackenbach MJ, et al. Neurology. 2023 Aug 8;101(6):e594-e601. doi: 10.1212/WNL.0000000000207482. Epub 2023 Jun 19. Neurology. 2023. PMID: 37336766 Free PMC article.

In the first year of age, NfL levels in patients and controls were similar (10.3 vs 11.0 pg/mL), but mixed linear model analysis showed a yearly increase of NfL of 6.0% in patients, compared with a decrease of 8.8% in controls (p < 0.001). Higher NfL was associated with

In the first year of age, NfL levels in patients and controls were similar (10.3 vs 11.0 pg/mL), but mixed linear model analysis showed a ye …
Effects of enzyme replacement therapy on cardiac function in classic infantile Pompe disease.
Scheffers LE, Kok R, van den Berg LE, van den Hout JMP, Boersma E, van Capelle CI, Helbing WA, van der Ploeg AT, Koopman LP. Scheffers LE, et al. Int J Cardiol. 2023 Jun 1;380:65-71. doi: 10.1016/j.ijcard.2023.03.010. Epub 2023 Mar 8. Int J Cardiol. 2023. PMID: 36893858 Free article.
Median follow-up was 9.9 years (IQR: 7.5-16.3). Mean LVMI before start of ERT was increased 292.3 g/m(2) (95% CI: 202.8-381.8, mean Z-score + 7.6) and normalized after 1 year of ERT 87.3 g/m(2) (CI: 67.5-107.1, mean Z-score + 0.8, p < 0.001). ...
Median follow-up was 9.9 years (IQR: 7.5-16.3). Mean LVMI before start of ERT was increased 292.3 g/m(2) (95% CI: 202.8-381.8, mean Z …
Basal testosterone moderates responses to anger faces in humans.
Wirth MM, Schultheiss OC. Wirth MM, et al. Physiol Behav. 2007 Feb 28;90(2-3):496-505. doi: 10.1016/j.physbeh.2006.10.016. Epub 2006 Dec 18. Physiol Behav. 2007. PMID: 17174989
Prior research [van Honk J, Tuiten A, Verbaten R, van den Hout M, Koppeschaar H, Thijssen J, de Haan E. Correlations among salivary testosterone, mood, and selective attention to threat in humans. Horm Behav 1999;36(1):17-24; va
Prior research [van Honk J, Tuiten A, Verbaten R, van den Hout M, Koppeschaar H, Thijssen J
If you suffer from a headache, then you have a brain tumour: domain-specific reasoning 'bias' and hypochondriasis.
Smeets G, de Jong PJ, Mayer B. Smeets G, et al. Behav Res Ther. 2000 Aug;38(8):763-76. doi: 10.1016/s0005-7967(99)00094-7. Behav Res Ther. 2000. PMID: 10937425
The latter finding contrasts with the earlier study of de Jong et al. (1998) [de Jong, P. J., Haenen, M.-A., Schmidt, A., & Mayer, B. (1998a). Hypochondriasis: the role of fear-confirming reasoning. Behaviour Research and Therapy, 36, 65-74; de Jong, P
The latter finding contrasts with the earlier study of de Jong et al. (1998) [de Jong, P. J., Haenen, M.-A., Schmidt, A …
Diffusion tensor imaging of the brain in Pompe disease.
van den Dorpel JJA, Dremmen MHG, van der Beek NAME, Rizopoulos D, van Doorn PA, van der Ploeg AT, Muetzel RL, van den Hout JMP. van den Dorpel JJA, et al. J Neurol. 2023 Mar;270(3):1662-1671. doi: 10.1007/s00415-022-11506-z. Epub 2022 Dec 8. J Neurol. 2023. PMID: 36480052 Free PMC article.
In classic infantile patients, we found a significant lower FA and higher MD (p < 0.01) compared to the reference population. Large-association fibers were most severely affected. ...

In classic infantile patients, we found a significant lower FA and higher MD (p < 0.01) compared to the reference population. Larg

Comprehensive long-term efficacy and safety of recombinant human alpha-mannosidase (velmanase alfa) treatment in patients with alpha-mannosidosis.
Lund AM, Borgwardt L, Cattaneo F, Ardigò D, Geraci S, Gil-Campos M, De Meirleir L, Laroche C, Dolhem P, Cole D, Tylki-Szymanska A, Lopez-Rodriguez M, Guillén-Navarro E, Dali CI, Héron B, Fogh J, Muschol N, Phillips D, Van den Hout JMH, Jones SA, Amraoui Y, Harmatz P, Guffon N. Lund AM, et al. J Inherit Metab Dis. 2018 Nov;41(6):1225-1233. doi: 10.1007/s10545-018-0175-2. Epub 2018 May 3. J Inherit Metab Dis. 2018. PMID: 29725868 Free PMC article. Clinical Trial.

Serum oligosaccharide levels were significantly reduced in the overall population at 12 months (mean change: -72.7%, P < 0.001) and remained statistically significant at last observation (-62.8%, P < 0.001). A mean improvement of +9.3% in 3MSCT was observed at

Serum oligosaccharide levels were significantly reduced in the overall population at 12 months (mean change: -72.7%, P < 0.001) an

14 results