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Redox Homeostasis in Skeletal Muscle Aging

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Redox Signaling and Biomarkers in Ageing

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 15))

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Abstract

Aging and age-related complications are the major social burden that contributes to disability and other poor outcomes at a higher prevalence. However, no clear attempt has been made so far in terms of diagnosis and treatment. Despite considering several theories, the reactive oxygen species (ROS) production is the one that implicates in inducing aging and age-related diseases. Nevertheless, within certain concentrations, ROS can effectively regulate various age-related signaling pathways such as PGC-1 alpha, MAPK, and mTOR. Further, the optimal ROS concentration could provide better adaptation to the cells during initial oxidative stress response which could ultimately improve the antioxidant defense system and support against age-related complications. But studies have shown that removal of ROS during antioxidants treatment or genetic increase in these antioxidants did not improve the life extension which inconclusively provides debate of ROS-induced aging and diseases. Skeletal muscle loss is one of the major hallmarks of aging and ROS, and oxidative stress is considered to be the main cause of skeletal muscle aging. This chapter discusses how ROS can influence the aging of skeletal muscle including ROS-targeted signaling in aging and age-related complications.

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Acknowledgements

The authors would like to acknowledge Mr. Kishore Kumar who helped in editing the manuscript.

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Authors and Affiliations

  1. Faculty of Sports Science, Ningbo University, Ningbo, 315211, China

    Anand Thirupathi & Yaodong Gu

  2. Laboratory of Exercise Biochemistry in Health, Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil

    Ricardo A. Pinho

Authors
  1. Anand Thirupathi
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  2. Ricardo A. Pinho
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  3. Yaodong Gu
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Editors and Affiliations

  1. Department of Medical Biochemistry Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey

    Ufuk Çakatay

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The authors declare that there is no conflict of interest to declare.

Research Involving Human Participants and/or Animals:

This study does not involve any human and animals’ participants.

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Informed consent was obtained from all the individual participants in the study.

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Thirupathi, A., Pinho, R.A., Gu, Y. (2022). Redox Homeostasis in Skeletal Muscle Aging. In: Çakatay, U. (eds) Redox Signaling and Biomarkers in Ageing. Healthy Ageing and Longevity, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-030-84965-8_5

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