In the present investigation, a series of substituted hydroxytriazenes containing trifluoromethyl group were synthesized via diazocoupling reaction with phenylhydroxylamine. The structure of synthesized hydroxytriazenes has been assigned on the basis of elemental analysis, IR, 1H NMR and mass spectroscopy data. The lipid lowering effect of synthesized compounds was evaluated on triton-induced hyperlipidemia model in adult male Charles Foster rats. Administration of 400 mg/kg body wt. dose of triton WR 1339 causes elevation in total cholesterol, phospholipid, and triglyceride levels and inhibits post-heparin lipolytic activity, which was reversed by hydroxytriazenes. Adose of 100 mg/kg body wt. also inhibits free radical generation of superoxide anions and hydroxyl radicals and lipid oxidation.
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Acknowledgments
The authors are grateful to CDRI Lucknow for providing antidyslipidemic and antioxidant activity assay. They also acknowledge SAIF (IIT Madras, Chennai) for providing spectral analysis facility.
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Regar, M., Baroliya, P.K., Patidar, A. et al. Antidyslipidemic and Antioxidant Effects of Novel Hydroxytriazenes. Pharm Chem J 50, 310–314 (2016). https://doi.org/10.1007/s11094-016-1442-x
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DOI: https://doi.org/10.1007/s11094-016-1442-x