Skip to main content
SpringerLink
Log in

New considerations on hormetic response against oxidative stress

  • Research Article
  • Published:
Journal of Cell Communication and Signaling Aims and scope

Abstract

In order to survive living organisms have developed multiple mechanisms to deal with tough environmental conditions. Hormesis is defined as a process in which exposure to a low dose of a chemical agent or environmental factor that is damaging at higher doses induces an adaptive beneficial effect on the cell or organism. In this paper, we examine several ideas that might be taken into consideration before using hormesis as a therapeutic tool to improve health and life span, and hopefully will open the discussion for new and interesting debates regard hormesis. The first one is to understand that the same stressor or inductor can activate different pathways in a parallel or dual response, which might lead to diverse outcomes. Another idea is related to the mechanisms involved in activating Nrf2, which might be different and have diverse hormetic effects.

Last, we discuss mild oxidative stress in association to low-grade chronic inflammation as a stimulating avenue to be explored and the unexpected effects proposed by the obesity paradox theory. All the previous might help to clarify the reasons why centenarians are able to reach the extreme limits of human life span, which could probably be related to the way they deal with homeostasis maintenance, providing an opportunity for hormesis to intervene significantly.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Abbreviations

OCH :

Oxidative conditioning hormesis

H 2 O 2 :

Hydrogen peroxide

Nrf2 :

Nuclear factor erythroid-derived 2-like 2

Keap1 :

Kelch-like ECH-associated protein 1

ROS/RNS :

Reactive oxygen species/Reactive nitrogen species

CAT :

Catalase

SOD :

superoxide dismutase

GSH :

Reduced glutathione

PKC :

Protein kinase C

AOS :

Alginate oligosachharide

AGEs :

advanced glycation end products

tBHQ :

tert-butylhydroquinone

TBQ :

tertbutylbenzoquinone

MPP+ :

1-methyl-4-phenylpyridinium

References

  • Abiko Y, Miura T, Phuc BH, Shinkai Y, Kumagai Y (2011) Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole. Toxicol Appl Pharmacol 255:32–39

    Article  CAS  PubMed  Google Scholar 

  • Alarcón-Aguilar A, Luna-López A, Ventura-Gallegos JL, Lazzarini R, Galván-Arzate S, González-Puertos VY, Morán J, Santamaría A, Königsberg M (2014) Primary cultured astrocytes from old rats are capable to activate the Nrf2 response against MPP + toxicity after tBHQ pretreatment. Neurobiol Aging 35:1901–1912

    Article  PubMed  Google Scholar 

  • Barbieri M, Boccardi V, Papa M, Paolisso G (2009) Metabolic journey to healthy longevity. Horm Res 71:24–27

    Article  CAS  PubMed  Google Scholar 

  • Bayod S, Del Valle J, Lalanza JF, Sanchez-Roige S, de Luxán-Delgado B, Coto-Montes A, Canudas AM, Camins A, Escorihuela RM, Pallàs M (2012) Long-term physical exercise induces changes in sirtuin 1 pathway and oxidative parameters in adult rat tissues. Exp Gerontol 47:925–935

    Article  CAS  PubMed  Google Scholar 

  • Beddhu S (2004) The body mass index paradox and an obesity, inflammation, and atherosclerosis syndrome in chronic kidney disease. Semin Dial 17:229–232

    Article  PubMed  Google Scholar 

  • Bluher M (2012) Are there still healthy obese patients? Curr Opin Endocrinol Diabetes Obes 19:341–346

    Article  PubMed  Google Scholar 

  • Buelna-Chontal M, Guevara-Chávez JG, Silva-Palacios A, Medina-Campos ON, Pedraza-Chaverri J, Zazueta C (2014) Nrf2-regulated antioxidant response is activated by protein kinase C in postconditioned rat hearts. Free Radic Biol Med [Epub ahead of print]

  • Calabrese EJ (2008) Converging concepts: adaptive response, preconditioning, and the Yerkes–Dodson law are manifestations of hormesis. J Ageing Res Rev 7:8–20

    Article  CAS  Google Scholar 

  • Calabrese EJ, Baldwin LA (2003) Hormesis at the National Toxicology Program (NTP): evidence of hormetic dose responses in NTP dose-range studies. Nonlinear Biol Toxicol Med 1:455–467

    Article  CAS  Google Scholar 

  • Calabrese V, Cornelius C, Mancuso C, Lentile R, Stella AM, Butterfield DA (2010) Redox homeostasis and cellular stress response in aging and neurodegeneration. Methods Mol Biol 610:285–308

    Article  CAS  PubMed  Google Scholar 

  • Choi VW, Cheung AL, Cheng SH, Yu KN (2012) Hormetic effect induced by alpha-particle-induced stress communicated in vivo between zebrafish embryos. Environ Sci Technol 46:11678–11683

    Article  CAS  PubMed  Google Scholar 

  • Correa F, Buelna-Chontal M, Hernández-Reséndiz S, García-Niño WJ, Roldán F, Soto V, Silva-Palacios A, Amador A, Pedraza-Chaverrí J, Tapia E, Zazueta C (2013) Curcumin maintains cardiac and mitochondrial function in chronic kidney disease. Free Radic Biol Med 61C:119–129

    Article  Google Scholar 

  • Cui H, Kong Y, Zhang H (2011) Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct 2012:646354

    PubMed Central  PubMed  Google Scholar 

  • de Magalhaes JP, Curado J, Church GM (2009) Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics 25:875–881

    Article  PubMed Central  PubMed  Google Scholar 

  • Demirovic D, Rattan SI (2011) Curcumin induces stress response and hermetically modulates wound healing ability of human skin fibroblasts undergoing ageing in vitro. Biogerontology 12:437–444

    Article  CAS  PubMed  Google Scholar 

  • Epel ES, Lithgow GJ (2014) Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity. J Gerontol A Biol Sci Med Sci 69:S10–S16

    Article  CAS  PubMed  Google Scholar 

  • Erlank H, Elmann A, Kohen R, Kanner J (2011) Polyphenols activate Nrf2 in astrocytes via H2O2, semiquinones, and quinones. Free Radic Biol Med 51:2319–2327

    Article  CAS  PubMed  Google Scholar 

  • Flegal KM, Kalantar-Zadeh K (2013) Overweight, mortality and survival. Obesity 21:1744–1745

    PubMed Central  PubMed  Google Scholar 

  • Hayflick L (1998) How and why we age. Exp Gerontol 33:639–653

    Article  CAS  PubMed  Google Scholar 

  • García-Niño WR, Pedraza-Chaverrí J (2014) Protective effect of curcumin against heavy metals-induced liver damage. Food Chem Toxicol 69C:182–201

    Article  Google Scholar 

  • Gopalakrishna R, Jaken S (2000) Protein kinase C signaling and oxidative stress. Free Radic Biol Med 28:1349–1361

    Article  CAS  PubMed  Google Scholar 

  • Gopalakrishna R, McNeill TH, Elhiani AA, Gundimeda U (2013) Methods for studying oxidative regulation of protein kinase C. Meth Enzymol 528:79–98

    Article  CAS  PubMed  Google Scholar 

  • Grynkiewicz G, Ślifirski P (2012) Curcumin and curcuminoids in quest for medicinal status. Acta Biochem Pol 59:201–212

    CAS  Google Scholar 

  • Hashmi MZ, Khan KY, Hu J, Naveedullah, Su X, Abbas G, Yu C, Shen C (2014) Hormetic effects of noncoplanar PCB exposed to human lung fibroblast cells (HELF) and possible role of oxidative stress. Environ Toxicol [Epub ahead of print]

  • Hayden A, Douglas J, Sommerlad M, Andrews L, Gould K, Hussain S, Thomas GJ, Packham G, Crabb SJ (2014) The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer. Urol Oncol [Epub ahead of print]

  • Hernández-Bautista RJ, Alarcón-Aguilar FJ, Del C, Escobar-Villanueva M, Almanza-Pérez JC, Merino-Aguilar H, Fainstein MK, López-Diazguerrero NE (2014) Biochemical alterations during the obese-aging process in female and Male Monosodium Glutamate (MSG)-treated mice. Int J Mol Sci 15:11473–11494

    Article  PubMed Central  PubMed  Google Scholar 

  • Hine CM, Mitchell JR (2012) NRF2 and the phase II response in acute stress resistance induced by dietary restriction. J Clin Exp Pathol S4:7329

    Article  PubMed  Google Scholar 

  • Hoffmann GR (2009) A perspective on the scientific, philosophical, and policy dimensions of hormesis. Dose Response 7:1–51

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hoffmann GR, Moczula AV, Laterza AM, Macneil LK, Tartaglione JP (2013) Adaptive response to hydrogen peroxide in yeast: induction, time course, and relationship to dose–response models. Environ Mol Mutagen 54:384–396

    Article  CAS  PubMed  Google Scholar 

  • Hotamisligil GS, Erbay E (2008) Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 8:923–934

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hsu YY, Chen CS, Wu SN, Jong YJ, Lo YC (2012) Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells. Eur J Pharm Sci 46:415–425

    Article  CAS  PubMed  Google Scholar 

  • Imhoff BR, Hansen JM (2010) Tert-butylhydroquinone induces mitochondrial oxidative stress causing Nrf2 activation. Cell Biol Toxicol 26:541–5

    Article  CAS  PubMed  Google Scholar 

  • Ishii T, Mann GE (2014) Redox status in mammalian cells and stem cells during culture in vitro: critical roles of Nrf2 and cystine transporter activity in the maintenance of redox balance. Redox Biol 2:786–794. doi:10.1016/j.redox.2014.04.008

  • Itoh K, Tong KI, Yamamoto M (2004) Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic Biol Med 36:1208–1213

    Article  CAS  PubMed  Google Scholar 

  • Jacobs AT, Marnett LJ (2007) Heat shock factor 1 attenuates 4-Hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XL. J Biol Chem 282:33412–33421

    Article  CAS  PubMed  Google Scholar 

  • Jin H, Kanthasamy A, Anantharam V, Rana A, Kanthasamy AG (2011) Transcriptional regulation of pro-apoptotic protein kinase C delta: implications for oxidative stress-induced neuronal cell death. J Biol Chem 286:19840–19859

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Kahn SE, Zinman B, Haffner SM, O’Neill MC, Kahn SE1, Zinman B, Haffner SM, O’Neill MC, Kravitz BG, Yu D, Freed MI, Herman WH, Holman RR, Jones NP, Lachin JM, Viberti GC. Obesity is a major determinant of the association of C-reactive protein levels and the metabolic syndrome in type 2 diabetes. Diabetes 55:2357–2364

  • Khoramian TS, Khalaj L, Ashabi G, Kiaei M, Khodagholi F (2011) Alginate oligosaccharide protects against endoplasmic reticulum- and mitochondrial-mediated apoptotic cell death and oxidative stress. Biomaterials 32:5438–545

    Article  Google Scholar 

  • Kleszczyński K, Ernst IM, Wagner AE, Kruse N, Zillikens D, Rimbach G, Fischer TW (2013) Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes. Pharmacol Res 78:28–40

    Article  PubMed  Google Scholar 

  • Kobayashi A, Yamamoto M (2006) Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv Enzym Regul 46:113–140

    Article  CAS  Google Scholar 

  • Kobayashi A, Kang M, Watai Y, Tong KI, Shibata T, Uchida K, Yamamoto M (2006) Oxidative and electrophilicstresses activate Nrf2 through inhibition of ubiquitination activity of Keap. Mol Cel Biol 26:221–229

    Article  CAS  Google Scholar 

  • Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M (2010) The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 12:213–223

    CAS  PubMed  Google Scholar 

  • Kregel KC, Zhang HJ (2007) An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. Am J Physiol Regul Integr Comp Physiol 292:18–36

    Article  Google Scholar 

  • Kubicova L1, Hadacek F, Chobot V (2013) Quinolinic acid: neurotoxin or oxidative stress modulator? Int J Mol Sci 14(11):21328–38

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Lainscak M, von Haehling S, Doehner W, Anker SD (2012) The obesity paradox in chronic diseases:facts and numbers. J Cachex Sarcopenia Muscle 3:1–4

    Article  Google Scholar 

  • Landbo C, Prescott E, Lange P, Vestbo J, Almdal TP (1999) Prognostic value of nutritional status in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160:1856–1861

    Article  CAS  PubMed  Google Scholar 

  • Le Bourg E, Rattan SI (2009) Is hormesis applicable as a pro-healthy aging intervention in mammals and human beings, and how? Introduction to a special issue of Dose-Response. Dose Response 8:1–3. doi:10.2203/dose-response.09-052

  • Lee MJ, Wu Y, Fried SK (2010) Adipose tissue remodeling in pathophysiology of obesity. Curr Opin Clin Nutr Metab Care 13:371–376

    Article  PubMed Central  PubMed  Google Scholar 

  • Lee SK, Shehzad A, Jung JC, Sonn JK, Lee JT, Park JW, Lee YS (2012) Protein kinase Cα protects against multidrug resistance in human colon cancer cells. Mol Cells 34:61–69

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Lerner C, Bitto A, Pulliam D, Nacarelli T, Konigsberg M, Van Remmen H, Torres C, Sell C (2013) Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts. Aging Cell 12:966–977

    Article  CAS  PubMed  Google Scholar 

  • Luna-López A, Triana-Martínez F, López-Diazguerrero NE, Ventura-Gallegos JL, Gutiérrez-Ruiz MC, Damián-Matsumura P, Zentella A, Gómez-Quiroz LE, Königsberg M (2010) Bcl-2 sustains hormetic response by inducing Nrf-2 nuclear translocation in L929 mouse fibroblasts. Free Radic Biol Med 49:1192–1204. doi:10.1016/j.freeradbiomed.2010.07.004

  • Matsuda M, Shimomura I (2013) Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. Obes Res Clin Pract 7:330–341

    Article  Google Scholar 

  • Mattson MP (2008) Hormesis and disease resistance: activation of cellular stress response pathways. Hum Exp Toxicol 27:155–162

    Article  PubMed  Google Scholar 

  • Meakin PJ, Chowdhry S, Sharma RS, Ashford FB, Walsh SV, McCrimmon RJ, Dinkova-Kostova AT, Dillon JF, Hayes JD, Ashford ML (2014) Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance. Mol Cell Biol 34:3305–3320

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Mendelsohn AR, Larrick JW (2014) Paradoxical effects of antioxidants on cancer. Rejuvenation Res 17:306–311

    Article  CAS  PubMed  Google Scholar 

  • Mendoza-Núñez VM, Sánchez-Rodríguez MA, Correa-Muñoz E (2009) Undernutrition and oxidative stress as risk factors for high blood pressure in older Mexican adults. Ann Nutr Metab 54:119–123

    Article  PubMed  Google Scholar 

  • Mishra S, Vinayak M (2014) Ellagic acid inhibits PKC signaling by improving antioxidant defense system in murine T cell lymphoma. Mol Biol Rep 4:4187–4197

    Article  Google Scholar 

  • Morimoto RI, Cuervo AM (2014) Proteostasis and the aging proteome in health and disease. J Gerontol A Biol Sci Med Sci 69(Suppl 1):S33–8

    Article  CAS  PubMed  Google Scholar 

  • Mukherjee S, Ghosh S, Choudhury S, Adhikary A, Manna K, Dey S, Sa G, Das T, Chattopadhyay S (2013) Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-κB pathways. J Nutr Biochem 24:2040–2050

    Article  CAS  PubMed  Google Scholar 

  • Namani A, Li Y, Wang XJ, Tang X (2014) Modulation of NRF2 signaling pathway by nuclear receptors: implications for cancer. Biochim Biophys Acta 1843:1875–1885

    Article  CAS  PubMed  Google Scholar 

  • Niture SK, Jaiswal AK (2012) Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis. J Biol Chem 287:9873–9886

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Niture SK, Jain AK, Jaiswal AK (2009) Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance. J Cell Sci 122:4452–4464

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Nunn AVW, Bell JD, Guy GW (2009) Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe? kNutr Metab 6:16

    Article  Google Scholar 

  • Okin D, Medzhitov R (2012) Evolution of inflammatory diseases. Curr Biol 22:733–740

    Article  Google Scholar 

  • Park SH, Jang JH, Chen CY, Na HK, Surh YJ (2010) A formulated red ginseng extract rescues PC12 cells from PCB-induced oxidative cell death through Nrf2-mediated upregulation of heme oxygenase-1 and glutamate cysteine ligase. Toxicology 278:131–139

    Article  CAS  PubMed  Google Scholar 

  • Pulliam DA, Deepa SS, Liu Y, Hill S, Lin AL, Bhattacharya A, Shi Y, Sloane L, Viscomi C, Zeviani M, Van Remmen H (2014) Complex IV deficient surf1−/− mice initiate mitochondrial stress responses. Biochem J. [Epub ahead of print]

  • Queisser N, Oteiza PI, Link S, Hey V, Stopper H, Schupp N (2014) Aldosterone activates transcription factor Nrf2 in kidney cells both in vitro and in vivo. Antioxid Redox Signal. [Epub ahead of print]

  • Rattan SI (2006) Hormetic modulation of aging and longevity by mild heat stress. Dose Response 3:533–546

    Article  PubMed Central  PubMed  Google Scholar 

  • Ravuri C1, Svineng G, Huseby NE (2013) Differential regulation of γ-glutamyltransferase and glutamate cysteine ligase expression after mitochondrial uncoupling: γ-glutamyltransferase is regulated in an Nrf2- and NFκB-independent manner. Free Radic Res 47:394–403

    Article  CAS  PubMed  Google Scholar 

  • Ristow M, Schmeisser S (2011) Extending life span by increasing oxidative stress. Free Radic Biol Med 51:327–336

    Article  CAS  PubMed  Google Scholar 

  • Rohrer PR, Rudraiah S, Goedken MJ, Manautou JE (2014) Is nuclear factor erythroid 2-related factor 2 responsible for sex differences in susceptibility to acetaminophen-induced hepatotoxicity in mice? Drug Metab Dispos 42:1663–1674

    Article  CAS  PubMed  Google Scholar 

  • Rubio V, Valverde M, Rojas E (2010) Effects of atmospheric pollutants on the Nrf2 survival pathway. Environ Sci Pollut Res Int 17:369–382

    Article  CAS  PubMed  Google Scholar 

  • Santana-Martínez RA, Galván-Arzáte S, Hernández-Pando R, Chánez-Cárdenas ME, Avila-Chávez E, López-Acosta G, Pedraza-Chaverrí J, Santamaría A, Maldonado PD (2014) Sulforaphane reduces the alterations induced by quinolinic acid: modulation of glutathione levels. Neuroscience 272:188–198

    Article  PubMed  Google Scholar 

  • Satoh T, McKercher SR, Lipton SA (2013) Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs. Free Radic Biol Med 65:645–57

    Article  CAS  PubMed  Google Scholar 

  • Scannapieco AC, Sørensen JG, Loeschcke V, Norry FM (2007) Heat-induced hormesis in longevity of two sibling drosophila species. Biogerontology 8:315–325

    Article  CAS  PubMed  Google Scholar 

  • Shaw PX, Werstuck G, Chen Y (2014) Oxidative medicine and cellular longevity. Oxi Med Cel Longev 569146

  • Shoelson SE, Lee J, Goldfine AB (2006) Inflammation and insulin resistance. J Clin Investig 7:1793–1801

    Article  Google Scholar 

  • Singh B, Shoulson R, Chatterjee A, Ronghe A, Bhat NK, Dim DC, Bhat HK (2014) Resveratrol inhibits estrogen-induced breast carcinogenesis through induction of NRF2-mediated protective pathways. Carcinog. [Epub ahead of print]

  • Song HJ, Oh S, Quan S, Ryu OH, Jeong JY, Hong KS, Kim DH (2014) Gender differences in adiponectin levels and body composition in older adults: hallym aging study. BMC Geriatr 14:8

    Article  PubMed Central  PubMed  Google Scholar 

  • Speciale A, Chirafisi J, Saija A, Cimino F (2011) Nutritional antioxidants and adaptive cell responses: an update. Curr Mol Med 11:770–789

    Article  CAS  PubMed  Google Scholar 

  • Taguchi K, Fujii S, Yamano S, Cho AK, Kamisuki S, Nakai Y, Sugawara F, Froines JR, Verhagen H, Furnee C, Schutte B, Hermans R, Kumagai Y (2007) An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the hydroquinone associatedwith oxidativestress. Free Radic Biol Med 43:789–799

    Article  CAS  PubMed  Google Scholar 

  • Trujillo J1, Chirino YI, Molina-Jijón E, Andérica-Romero AC, Tapia E, Pedraza-Chaverrí J (2013) Renoprotective effect of the antioxidant curcumin: recent findings. Redox Biol 1:448–456

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Uretsky S, Messerli FH, Bangalore S, Champion A, Cooper-Dehoff RM, Zhou Q, Pepine CJ (2007) Obesity paradox in patients with hypertension and coronary artery disease. Am J Med 120:863–870

    Article  PubMed  Google Scholar 

  • Vida C, Gonzalez EM, Fuente MD (2014) Increase of oxidation and inflammation in nervous and immune systems withaging and anxiety. Curr Pharm Des [Epub ahead of print]

  • Wakabayashi N, Itoh K, Wakabayashi J, Motohashi H, Noda S, Takahashi S, Imakado S, Kotsuji T, Otsuka F, Roop DR, Harada T, Engel JD, Yamamoto M (2003) Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet 35:238–245

    Article  CAS  PubMed  Google Scholar 

  • Wang W, Wu Y, Zhang G, Fang H, Wang H, Zang H, Xie T, Wang W (2014a) Activation of Nrf2-ARE signal pathway protects the brain from damage induced by epileptic seizure. Brain Res 1544:54–61

    Article  CAS  PubMed  Google Scholar 

  • Wang XJ, Li Y, Luo L, Wang H, Chi Z, Xin A, Li X, Wu J, Tang X (2014b) Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs. Free Radic Biol Med 70:68–77. doi:10.1016/j.freeradbiomed.2014.02.010

  • Wiese AG, Pacifici RE, Davies KJA (1995) Transcient adaptation to oxidative stress in mammalian cells. Arch Biochem Biophys 318:231–240

    Article  CAS  PubMed  Google Scholar 

  • Xu J, Wang H, Ding K, Zhang L, Wang C, Li T, Wei W, Lu X (2014) Luteolin provides neuroprotection in models of traumatic brain injury via the Nrf2–ARE pathway. Free Radic Biol Med 71:186–195

    Article  CAS  PubMed  Google Scholar 

  • Yadav A, Kataria MA, Saini V, Yadav A (2013) Role of leptin and adiponectin in insulin resistance. Clin Chim Acta 417:80–84

    Article  CAS  PubMed  Google Scholar 

  • Yan L (2014) Positive oxidative stress in aging and aging-related disease tolerance. Redox Biol 2:165–169

    Article  CAS  Google Scholar 

  • Zanotto-Filho A, Gelain DP, Schröder R, Souza LF, Pasquali MA, Klamt F, Moreira JC (2009) The NF kappa B-mediated control of RS and JNK signaling in vitamin A-treated cells: duration of JNK-AP-1 pathway activation may determine cell death or proliferation. Biochem Pharmacol 77:1291–1301

    Article  CAS  PubMed  Google Scholar 

  • Zucker SN, Fink EE1, Bagati A, Mannava S, Bianchi-Smiraglia A, Bogner PN, Wawrzyniak JA, Foley C, Leonova KI, Grimm MJ, Moparthy K, Ionov Y, Wang J, Liu S, Sexton S, Kandel ES, Bakin AV, Zhang Y, Kaminski N, Segal BH, Nikiforov MA (2014) Nrf2 amplifies oxidative stress via induction of Klf9. Mol Cell 53:916–928

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The authors want to acknowledge M. in BE Luis A. Maciel for his comments to this paper. This work was supported by CONACyT’s grant CB-2012-1-178349. As well as the “Red Temática de Investigación en Salud y Desarrollo Social” from CONACYT and INGER DI-PI004/2012.

Author information

Authors and Affiliations

  1. Instituto Nacional de Geriatría, SSA, México, D.F, 14080, Mexico

    Armando Luna–López

  2. Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, A.P. 55-535, C.P 09340, México, D.F, Mexico

    Viridiana Y. González-Puertos, Norma E. López-Diazguerrero & Mina Königsberg

Authors
  1. Armando Luna–López
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Viridiana Y. González-Puertos
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Norma E. López-Diazguerrero
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mina Königsberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mina Königsberg.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Luna–López, A., González-Puertos, V.Y., López-Diazguerrero, N.E. et al. New considerations on hormetic response against oxidative stress. J. Cell Commun. Signal. 8, 323–331 (2014). https://doi.org/10.1007/s12079-014-0248-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12079-014-0248-4

Keyword

Search

Navigation