Phase Transitions of Associative Biomacromolecules
- Rohit V. Pappu*
Rohit V. Pappu*Email: [email protected]Department of Biomedical Engineering, Center for Biomolecular Condensates (CBC), Washington University in St. Louis, St. Louis, Missouri 63130, United StatesMore by Rohit V. Pappu
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- Samuel R. Cohen
Samuel R. CohenDepartment of Biomedical Engineering, Center for Biomolecular Condensates (CBC), Washington University in St. Louis, St. Louis, Missouri 63130, United StatesCenter of Regenerative Medicine, Washington University in St. Louis, St. Louis, Missouri 63130, United StatesMore by Samuel R. Cohen
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- Furqan Dar
Furqan DarDepartment of Biomedical Engineering, Center for Biomolecular Condensates (CBC), Washington University in St. Louis, St. Louis, Missouri 63130, United StatesMore by Furqan Dar
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- Mina Farag
Mina FaragDepartment of Biomedical Engineering, Center for Biomolecular Condensates (CBC), Washington University in St. Louis, St. Louis, Missouri 63130, United StatesMore by Mina Farag
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- Mrityunjoy Kar
Mrityunjoy KarMax Planck Institute of Cell Biology and Genetics, 01307 Dresden, GermanyMore by Mrityunjoy Kar
Abstract
Multivalent proteins and nucleic acids, collectively referred to as multivalent associative biomacromolecules, provide the driving forces for the formation and compositional regulation of biomolecular condensates. Here, we review the key concepts of phase transitions of aqueous solutions of associative biomacromolecules, specifically proteins that include folded domains and intrinsically disordered regions. The phase transitions of these systems come under the rubric of coupled associative and segregative transitions. The concepts underlying these processes are presented, and their relevance to biomolecular condensates is discussed.
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