Structural Similarities and Differences between Amyloidogenic and Non-Amyloidogenic Islet Amyloid Polypeptide (IAPP) Sequences and Implications for the Dual Physiological and Pathological Activities of These Peptides
Table 2
Diminished amount of putative helix-coil hormone-competent conformation in hIAPP relative to rIAPP seen in simulation, and its link to diminished normal hormone function of hIAPP relative to rIAPP.